Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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A Brief Overview of Escherichia coli O157:H7 and Its Plasmid O157

  • Lim, Ji-Youn (Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho) ;
  • Yoon, Jang-W. (Advanced Human Resource and Research Group for Medical Science (BK21), Konkuk University, School of Medicine) ;
  • Hovde, Carolyn J. (Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho)
  • Published : 2010.01.31
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Abstract

Enterohemorrhagic Escherichia coli O157:H7 is a major foodborne pathogen causing severe disease in humans worldwide. Healthy cattle are a reservoir of E. coli O157:H7, and bovine food products and fresh produce contaminated with bovine waste are the most common sources for disease outbreaks in the United States. E. coli O157:H7 also survives well in the environment. The abilities to cause human disease, colonize the bovine gastrointestinal tract, and survive in the environment require that E. coli O157:H7 adapt to a wide variety of conditions. Three major virulence factors of E. coli O157:H7 have been identified including Shiga toxins, products of the pathogenicity island called the locus of enterocyte effacement, and products of the F-like plasmid pO157. Among these virulence factors, the role of pO157 is least understood. This review provides a board overview of E. coli O157:H7 with an emphasis on pO157.

Keywords

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