Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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Sialadenoma papilliferum: a case report and immunohistochemical study review

Sialadenoma papilliferum: 증례보고 및 면역조직화학적 고찰

  • Byun, June-Ho (Department of Oral and Maxillofacial Surgery, School of Medicine, Institute of Health Sciences, Gyeongsang National University) ;
  • Kim, Dong-Chul (Department of Pathology, School of Medicine, Gyeongsang National University) ;
  • Go, Gyung-Hyuck (Department of Pathology, School of Medicine, Gyeongsang National University) ;
  • Park, Bong-Wook (Department of Oral and Maxillofacial Surgery, School of Medicine, Institute of Health Sciences, Gyeongsang National University)
  • Received : 2010.08.27
  • Accepted : 2010.12.17
  • Published : 2010.12.31
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Abstract

Sialadenoma papilliferum (SP) is a rare benign neoplasm that normally arises from the minor salivary glands, particularly in the palate. SP is normally encountered in older men with an exophytic papillary surface growth. In the present study, an SP of the hard palate of a 69-year-old woman was examined immunohistochemically. Myoepithelial cell markers, such as S-100, smooth muscle actin and vimentin, were observed in the basal or luminal layer of tumor cells, indicating that myoepithelial cells participate in the pathogenesis of SP. In addition, cytokeratin 7 was also strongly detected in the tumor cells, suggesting that excretory ductal epithelial cells have a role in its histogenesis. A review of the literature of immunohistochemical studies on SP showed that the expression and co-expression of cytokeratins and myoepithelial cell markers have been reported in tumor cells. These results suggested that excretory duct cells and myoepithelial cells participate in the pathogenesis of SP.

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References

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