Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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Genetic influence and heritability in mandibular prognathism of Korean families

한국인 하악전돌증환자의 유전적 영향과 유전율에 대한 분석

  • Kim, Young-Ho (Department of Orthodontics, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Cho, Han-Young (Department of Orthodontics, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Baek, Chae-Hwan (Department of Oral and Maxillofacial Surgery, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Lee, Ah-Young (Department of Orthodontics, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Kim, Gun-Jong (Department of Oral and Maxillofacial Surgery, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Kim, Whi-Young (Research Center for Future Medicine, Samsung Medical Center) ;
  • Suh, Young-Ju (Clinical Research Institute, School of Medicine, Inha University) ;
  • Baek, Seung-Hak (Department of Orthodontics, School of Dentistry, Dental Research Institute, Seoul National University) ;
  • Hong, Jong-Rak (Department of Oral and Maxillofacial Surgery, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Paeng, Jun-Young (Department of Oral and Maxillofacial Surgery, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University)
  • 김영호 (성균관대학교 의과대학 삼성서울병원 교정과) ;
  • 조한영 (성균관대학교 의과대학 삼성서울병원 교정과) ;
  • 백채환 (성균관대학교 의과대학 삼성서울병원 구강악안면외과) ;
  • 이아영 (성균관대학교 의과대학 삼성서울병원 교정과) ;
  • 김군종 (성균관대학교 의과대학 삼성서울병원 구강악안면외과) ;
  • 김휘영 (삼성의료원 미래의학연구센터) ;
  • 서영주 (인하대학교 의학전문대학원 임상연구부) ;
  • 백승학 (서울대학교 치의학전문대학원 교정과) ;
  • 홍종락 (성균관대학교 의과대학 삼성서울병원 구강악안면외과) ;
  • 팽준영 (성균관대학교 의과대학 삼성서울병원 구강악안면외과)
  • Received : 2010.08.31
  • Accepted : 2010.12.17
  • Published : 2010.12.31
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Abstract

Introduction: This study examined the genetic influence of mandibular prognathism epidemiologically in Korean families. Materials and Methods: Over a 5-year period from 2005 to 2009, a questionnaire with a pedigree chart was given to 100 (male 51, female 49) probands with skeletal Class III mandibular prognathism, who had undergone orthognathic surgery in Samsung Medical Center. Results: The average age of the probands was 22.1. The average SNA, SNB and ANB angles of the probands were $81.2^{\circ}$, $84.1^{\circ}$ and $-2.9^{\circ}$, respectively. A total of 2729 (male 1,354, female 1,375) family members were examined, and the affected ratio of the families was 3.5% with no significant difference between genders. 45% of families had at least one member with a Class III malocclusion other than the proband. The affected ratio of the first-degree relatives (10.9%) was significantly higher than those of the second-degree (3.3%) and third-degree (1.9%) relatives. The affected ratio of the total relatives from the male probands (4.2%) was significantly higher than that of the female probands (2.8%). Heritability ($h^2$, Falconer' method) was estimated to be 29.8% ($0.298{\pm}0.059$) in first-degree relatives. Conclusion: These results showed the significant influence of mandibular prognathism with relatively low heritability in first-degree relatives in Korean families of probands, who had undergone orthognathic surgery to correct a skeletal Class III malocclusion.

Keywords

References

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