Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

Clinical Outcome of the Squamous Cell Carcinoma of Tongue: Experience of National Cancer Center

국립암센터에서 치료한 설암 환자의 생존율 분석을 통한 예후인자 분석

  • Kim, Tae-Woon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Jo, Sae-Hyung (Oral Oncology Clinic, Research Institute and Hospital, National Cancer center) ;
  • Min, Seung-Ki (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Lee, Jong-Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Kim, Myung-Jin (Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University) ;
  • Park, Joo-Yong (Oral Oncology Clinic, Research Institute and Hospital, National Cancer center) ;
  • Choi, Sung-Weon (Oral Oncology Clinic, Research Institute and Hospital, National Cancer center)
  • 김태운 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 조세형 (국립암센터 구강종양클리닉) ;
  • 민승기 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 이종호 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 김명진 (서울대학교 치의학대학원 구강악안면외과학교실) ;
  • 박주용 (국립암센터 구강종양클리닉) ;
  • 최성원 (국립암센터 구강종양클리닉)
  • Received : 2010.08.04
  • Accepted : 2010.11.01
  • Published : 2010.11.30
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Abstract

Purpose: The objective of this study is to evaluate the survival rate and influencing factors. Patients and Methods: We studied 104 patients who were diagnosed for squamous cell carcinoma of tongue and received curative treatment in oral oncology clinic of National Cancer Center from June 2001 to December 2009. Results: We found the following results. 1. The overall 5-year survival rate of tongue cancer was 67.0% and there was no significant statistical difference between male and female. 2. A lower survival rate was shown in patients under 40 years (42.2%) than over 40 years (75.5%)(P < 0.05). 3. 5-year survival rates of patients with tongue cancer classified by pTNM classification were 87.4% in early stage and 43.3% (P < 0.05). 4. A higher survival rate was seen in patients without cervical lymph node metastasis (82.0% > 44.1%)(P < 0.05). 5. A higher survival rate was seen in patients of tongue cancer with higher differenciation grade (P < 0.05). 6. It is well known that drinking and smoking have great influence on the survival rate of patients of squamous cell carcinoma of tongue. But these was no statistical significance. Conclusion: The overall 5-year survival rate of tongue cancer was 67.0% and it was mostly influenced by factors like age, pTNM stage, cervical lymph node metastasis, differentiation of cancer cell etc.

Keywords

References

  1. Ministry of health and welfare : Assortment of reason for death : 209, 2000.
  2. Parken DM, Laara E, Muir CS : Estimates of the worldwide frequency of sixteen major cancers in 1980. Int J Cancer 41 : 184, 1988. https://doi.org/10.1002/ijc.2910410205
  3. Lee EW : Early Finding of Oral Cancer and role of dentist: JKDA 24 : 576, 1988.
  4. Bray F, Sankila R, Ferlay J et al : Estimates of cancer incidence and mortality in Europe in 1995. Euro J Cancer 38 : 99, 2002. https://doi.org/10.1016/S0959-8049(01)00350-1
  5. Arduino PG, Carrozzo M, Chiecchio A et al : Clinical and histopathologic independent prognostic factors in oral squamous cell carcinoma: A retrospective study of 334 cases. J Oral Maxillofac Surg 66 : 1570, 2008. https://doi.org/10.1016/j.joms.2007.12.024
  6. Kruaysawat W, Aekplakorn W, Chapman RS : Survival time and prognostic factors of oral cancer in Ubon Ratchathani Cancer Center. J Med Assoc Thai 93 : 278, 2010.
  7. Hessel AC, Moreno MA, Hanna EY et al : Compliance with quality assurance measures in patients treated for early oral tongue cancer. Cancer. 16 : 3408, 2010.
  8. Shim SJ, Cha J, Koom WS et al : Clinical outcomes for T1-2N0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy. Radiat Oncol. 27 : 43, 2010.
  9. Chun-Ta Liao, Shiang-Fu Huang, I-How Chen et al : Tongue and Buccal Mucosa Carcinoma: Is There a Difference in outcome. Ann Surg Oncol 22 : 974, 2010.
  10. Helliwell TR, Woolgar JA : Minimum Dataset for Head and Neck Carcinoma Histopathology Reports. Bulletin of the Royal College of Pathologist : 354, 1999.
  11. Bernier J, Domenge C, Ozsahin M et al : Postoperative irradiation with or without concomitant chemotherapy for locally advanced headand neck cancer. N Engl J Med 350 : 1945, 2004. https://doi.org/10.1056/NEJMoa032641
  12. Cooper JS, Pajak TF, Forastiere AA et al : Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell arcinoma of the head and neck. N Engl J Med 350 : 1937, 2004. https://doi.org/10.1056/NEJMoa032646
  13. Greene FL, Page DL, Fleming ID et al : AJCC Cancer Staging Manual. 6th ed. New York, Springer, 2002, p.13.
  14. Funk GF, Karnell LH, Robinson RA et al : Presentation, treatment, and outcome of oral cavity cancer: A national cancer data base report. Head Neck 24 : 165, 2002. https://doi.org/10.1002/hed.10004
  15. Cho JH, Kim CS : Clinical and statistical analysis of the oral cnacer patients : A statistical analysis of 256 cases. J Korean Assoc Maxillofac Plast Reconstr Surg 20 : 33, 1998.
  16. Hindle I, Downer MC, Speight PM : The epidemiology of oral cancer. Br J Oral and Maxillofac Surg 34 : 471, 1996. https://doi.org/10.1016/S0266-4356(96)90111-4
  17. Ryu SY, Park MS : Retrospective study of the oral cancer patients : A statistical analysis of 89 cases. J Kor Assoc Oral Maxillofac Surg 22 : 643, 1996.
  18. Chandu A, Adams G, Smith ACH : Factors affecting survival in patients with oral cancer: an Australian perspective. Int J Oral Maxillofac Surg 34 : 514, 2005. https://doi.org/10.1016/j.ijom.2004.10.006
  19. Woolgar JA, Rogers S, West CR : Survival and patterns of recurrence in 200 oral cancer patients treated by radical surgery and neck dissection. Oral Oncology 35 : 257, 1999. https://doi.org/10.1016/S1368-8375(98)00113-4
  20. Cho BH, Min SK, Oh SH et al : Retrospective study on the influencing factors of survival rate after treatments of oral cancer. J Korean Assoc Maxillofac Plast Reconstr Surg 24 : 211, 2002.
  21. Morris LG, Patel SG, Shah JP et al : Squamous cell carcinoma of the oral tongue in the pediatric age group: a matched-pair analysis of survival. Arch Otolaryngol Head Neck Surg 136 : 697, 2010. https://doi.org/10.1001/archoto.2010.94
  22. O'Brien CJ, Smith JW, Soong SJ et al : Neck dissection with and without radiotherapy : Prognostic factors, patterns of recurrence, and survival. Am J Surg 152 : 456, 1986. https://doi.org/10.1016/0002-9610(86)90324-7
  23. Montoro JR, Ricz HA, Souza L et al : Prognostic factors in squamous cell carcinoma of the oral cavity. Braz J Otorhinolaryngol 74 : 861, 2008.
  24. Byers RM, EL-Naggar AK, Lee YY : Can We detect or predict the presence of occult nodal metastases in patients with squamous carcinamo of the oral tongue. Head Neck 20 : 138, 1980.
  25. Ho CM, Lam KH, Wei WI : Occult lymph node metastasis in small oral tongue cancers. Head Neck 14 : 359, 1992. https://doi.org/10.1002/hed.2880140504
  26. Yuen AP, Wei WI, Wong YM et al : Elective neck dissection versus observation in the treatment of early oral tongue carcinoma. Head Neck. 19 : 583, 1997. https://doi.org/10.1002/(SICI)1097-0347(199710)19:7<583::AID-HED4>3.0.CO;2-3
  27. Funk GF, Karnell LH, Robinson RA et al : Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report. Head Neck. 24 : 165, 2002. https://doi.org/10.1002/hed.10004
  28. Lybak S, Liavaag PG, Monge OR et al : Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma. Eur Arch Otorhinolaryngol. 28 : 660, 2010.
  29. Chen YK, Huang HC, Lin LM et al : Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan. 35 : 173, 1999. https://doi.org/10.1016/S1368-8375(98)00101-8
  30. Neville, Damm, Allen et al : Oral & Maxillofacial Pathology, 2nd ed. Philadelphia, WB Saunders, 2002, p.345.
  31. Liewellyn CD, Johnson NW, Warnakulasuriya KAAS : Risk factors for squamous cell carcinoma of the oral cavity in young people - acomprehensive literature review. Oral Oncol 37 : 401, 2001. https://doi.org/10.1016/S1368-8375(00)00135-4
  32. Liewellyn CD, Linklater K, Bell J et al : An analysis of risk factors for oral cancer in young people : a casecontrol study. Oral Oncol 40 : 304, 2004. https://doi.org/10.1016/j.oraloncology.2003.08.015