Reverse Patent Ductus Arteriosus with an Aberrant Left Common Carotid Artery in a Shih Tzu Dog

시츄개에서 발생한 비정상적 좌경동맥 분지장애를 동반한 우-좌형 동맥관 개존증

  • Han, Suk-Hee (Section of Small Animal Internal Medicine, Kangwon National University) ;
  • Yoon, Byung-Il (Section of Histology, College of Veterinary Medicine, Kangwon National University) ;
  • Hyun, Chang-Baig (Section of Small Animal Internal Medicine, Kangwon National University)
  • 한숙희 (강원대학교 수의과대학 소동물 내과교실) ;
  • 윤병일 (강원대학교 수의과대학 조직학 교실) ;
  • 현창백 (강원대학교 수의과대학 소동물 내과교실)
  • Accepted : 2010.08.12
  • Published : 2010.10.30

Abstract

A 4-year-old intact male Shih Tzu dog (weighing 5 kg), was presented with signs of severe dyspnea, exercise intolerance and cyanosis. Diagnostic studies suggested a reverse patent ductus arteriosus (rPDA) with pneumonia. Despite emergency treatments with oxygen, diuretics, antibiotics and medical therapy for hyperkalemia, the dog died of ventricular fibrillation from hyperkalemia and dehydration. Necropsy revealed the rPDA with a marked descending aortic dilation and abnormally arisen left common carotid artery.

4살 된 시츄개(체중 5 kg)가 청색증을 동반한 심한 호흡곤란과 운동 불내성으로 내원하였다. 진단검사를 통해 우-좌형 동맥관 개존증과 비정상적인 대동맥 분지장애(좌총경정맥 잔존) 및 세균성 폐렴이 확진되었다. 환자는 이뇨제, 항생제, 산소요법 및 고칼륨혈증에 대한 처치에 불구하고 심한 고칼륨혈증에 의한 심실성 부정맥과 탈수에 의해 폐사하였다. 부검을 통해 심한 대동맥궁 확장과 비정상적인 좌총경정맥 분지 잔존을 확인하였다.

Keywords

References

  1. Oyama MA, Sisson DD, Thomas WP, Binagura JD. Lesions that cause right-to-left shunting: cyanotic heart disease. In: Textbook of Veterinary Internal Medicine, St Louis: Elsevier Saunders. 2005: 972-1022.
  2. Latshaw WK. Veterinary developmental anatomy. Toronto: BC Decker Inc. 1987: 181-188.
  3. Bezuidenhout A J. Anomalous origins of the right subclavian and common carotid arteries in the dog. J S Afr Vet Assoc 1989; 60:215-218.
  4. Boerman RH, Padberg GWAM, Wondergem JG, de Groot AC. Anomalous origin of the common carotid arteries as a cause of stroke. Clin Neurol Neurosug 1991; 94: 317-319.
  5. Chahwan S, Miller MT, Kim KA, Mantell M, Kirksey L. Aberrant right subclavian artery associated with a common origin of carotid arteries. Ann Vasc Surg 2006; 20: 809-812. https://doi.org/10.1007/S10016-006-9074-3
  6. Griffiths D. Three cases of aberrant right subclavian artery in the dog. Acta Vet Scand 1989; 30: 355-357.
  7. Johnson L, Boon J, Orton EC. Clinical characteristics of 53 dogs with Doppler-derived evidence of pulmonary hypertension: 1992-1996. J Vet Intern Med 1999; 13: 440-443.
  8. Janatova T, Jarkovska D, Hruda J, Samanek M, Ostadal B. Effect of the administration of prostaglandins (PGE2) in the early postnatal period on closure of the ductus arteriosus in the laboratory rat. Physiol Bohemoslov 1989; 38: 201-206.
  9. Zhao F, Weismann CG, Satoda M, Pierpont ME, Sweeney E, Thompson EM, Gelb BD. Novel TFAP2B mutations that cause Char syndrome provide a genotype-phenotype correlation. Am J Hum Genet 2001; 69: 695-703. https://doi.org/10.1086/323410
  10. Kurihara Y, Kurihara H, Oda H, Maemura K, Nagai R, Ishikawa T, Yazaki Y. Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. J Clin Invest 1995; 96: 293-300. https://doi.org/10.1172/JCI118033
  11. Ohnemus S, Kanzler B, Jerome-Majewska LA, Papaioannou VE, Boehm T, Mallo M. Aortic arch and pharyngeal phenotype in the absence of BMP-dependent neural crest in the mouse. Mech Dev 2002; 119: 127-135. https://doi.org/10.1016/S0925-4773(02)00345-3
  12. Xanthoulea S, Curfs DM, Hofker MH, de Winther MP. Nuclear factor kappaB signaling in macrophage function and atherogenesis. Curr Opin Lipidol 2005; 16: 536-542. https://doi.org/10.1097/01.mol.0000180167.15820.ae
  13. Nam YS, Lee CH, Chung DW, Yoon YS, Lee HS, Lee IS. Left costocervical vein malformation with anomalous ramification of aortic arch in a dog. J Vet Sci 2003; 4: 205-208.
  14. Nelson ML, Sparks CD. Unusual aortic arch variation: distal origin of common carotid arteries. Clin Anat 2001; 14: 62-65. https://doi.org/10.1002/1098-2353(200101)14:1<62::AID-CA1012>3.0.CO;2-#
  15. Yamane T, Awazu T, Fujii Y,;Watanabe T, Muto M, Okutsu M, Wakao Y. Aberrant branch of the bronchoesophageal artery resembling patent ductus arteriosus in a dog. J Vet Med Sci 2001; 63: 819-822. https://doi.org/10.1292/jvms.63.819
  16. Byrd NA, Meyers EN. Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo. Dev Biol 2005; 284: 233-245. https://doi.org/10.1016/j.ydbio.2005.05.023
  17. Mallick IH, Yang W, Winslet MC, Seifalian AM. Ischemiareperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci 200; 49: 1359-1377. https://doi.org/10.1023/B:DDAS.0000042232.98927.91