한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제27권5호
  • /
  • Pages.540-545
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  • 2010
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

Medetomidine/Tiletamine/Zolazepam 마취견에서 뇌전도를 이용한 외과마취의 평가

Prediction of Surgical Anesthesia in Medetomidine/Tiletamine/Zolazepam Anesthetized Dogs using Electroencephalography

  • 장환수 (경북대학 의과대학 약리학교실) ;
  • 김정은 (경북대학 의과대학 핵의학교실) ;
  • 임재현 (에이스 동물병원) ;
  • 권영삼 (경북대학교 수의과대학 수의외과학교실) ;
  • 이만기 (경북대학 의과대학 약리학교실) ;
  • 장광호 (경북대학교 수의과대학 수의외과학교실)
  • Jang, Hwan-Soo (Department of Pharmacology, School of Medicine, Kyungpook National University) ;
  • Kim, Jung-Eun (Department of Nuclear Medicine, School of Medicine, Kyungpook National University) ;
  • Lim, Jae-Hyun (Ace Animal Hospital) ;
  • Kwon, Young-Sam (Department of Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Maan-Gee (Department of Pharmacology, School of Medicine, Kyungpook National University) ;
  • Jang, Kwang-Ho (Department of Surgery, College of Veterinary Medicine, Kyungpook National University)
  • 심사 : 2010.09.30
  • 발행 : 2010.10.30
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초록

Medetomidine (MED)과 tiletamine/zolazepam (ZT)으로 마취한 개에서 외과 마취 상태 하에서의 뇌전도, 혈압 및 심박수 변화를 조사하였다. 외과 마취 수준을 결정하기 위해 ZT 주사 후, pedal withdrawal reflex를 규칙적으로 평가하였다. 통증반응을 보이지 않은 최초 시간은 외과마취 개시기로 결정하였다. 외과마취 개시기 후 처음으로 통증에 양성반응을 보이는 시간을 외과마취 종료기로 하였다. 대조군과 비교할 때 외과마취 개시기에 ${\delta}2$와 ${\alpha}2$의 유의적인 감소가 나타났으며 외과마취 종료기에, ${\delta}2$의 유의적인 변화가 관찰되었다. 외과마취 종료기 직전과 외과마취 종료기에 혈압이 유의적으로 감소하였다. 심박수는 전실험기간 유의적인 감소를 보였다. 이런 결과로 미루어 ${\delta}2$ band power는 MED와 ZT로 마취한 개에서 외과마취와 관련된 가치있는 지표로 판단되었다.

Changes of electroencephalogram (EEG), mean arterial blood pressure (MAP) and heart rate under surgical anesthesia were investigated in medetomidine (MED) and tiletamine/zolazepam (ZT)-anesthetized dogs. To determine the level of surgical anesthesia, pedal withdrawal reflex was regularly tested after ZT injection. The first time point without pain response was regarded as the beginning of surgical anesthesia (SSA). After SSA, the first time point showing positive pain response was considered the end of surgical anesthesia (ESA). Comparing the control, an additional significant decrease of ${\delta}2$ and ${\alpha}2$ was observed at SSA. Comparing the control, ${\delta}2$ was significantly decreased at ESA. Significant reductions of MAP were observed at pre-ESA and ESA. Heart rate significantly decreased in all stages. These results suggest that ${\delta}2$ band power is a valuable parameter for correlating surgical anesthesia in dogs anesthetized with MED and ZT.

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