Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Design and Synthesis of Resin-Conjugated Tamiflu Analogs for Affinity Chromatography

  • Kimura, Yasuaki (Graduate School of Pharmaceutical Sciences, The University of Tokyo) ;
  • Yamatsugu, Kenzo (Graduate School of Pharmaceutical Sciences, The University of Tokyo) ;
  • Kanai, Motomu (Graduate School of Pharmaceutical Sciences, The University of Tokyo) ;
  • Echigo, Noriko (Faculty of Pharmaceutical Sciences, Tokushima Bunri University) ;
  • Kuzuhara, Takashi (Faculty of Pharmaceutical Sciences, Tokushima Bunri University) ;
  • Shibasaki, Masakatsu (Graduate School of Pharmaceutical Sciences, The University of Tokyo)
  • Published : 2010.03.20
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Abstract

Two types of resin-conjugated Tamiflu analogs were synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resins bound to influenza virus neuraminidase, the main target of Tamiflu. The resins will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the rarely observed abnormal behavior exhibited by some influenza patients treated with Tamiflu.

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References

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