Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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A Case Report of MELAS syndrome Improved by Oriental Medicine Treatment

한방치료 후 호전된 MELAS 증후군 증례 1례

  • Seong, Kee-Moon (Dept. of Oriental Medicine, Gwang-ju Oriental Medical Hospital in Wonkwang University) ;
  • Yu, Deok-Seon (Dept. of Oriental Medicine, Gwang-ju Oriental Medical Hospital in Wonkwang University) ;
  • Choi, Byoung-Sun (Dept. of Oriental Medicine, Gwang-ju Oriental Medical Hospital in Wonkwang University) ;
  • Heo, Rae-Kyong (Dept. of Oriental Medicine, Gwang-ju Oriental Medical Hospital in Wonkwang University) ;
  • Jang, Myung-Jun (Dept. of Oriental Medicine, Gwang-ju Oriental Medical Hospital in Wonkwang University) ;
  • Lee, In-Yung (Dept. of Oriental Medicine, Gwang-ju Oriental Medical Hospital in Wonkwang University) ;
  • Song, Bong-Keun (Dept. of Oriental Medicine, Gwang-ju Oriental Medical Hospital in Wonkwang University)
  • 성기문 (원광대학교 광주한방병원 한방내과) ;
  • 유덕선 (원광대학교 광주한방병원 한방내과) ;
  • 최병선 (원광대학교 광주한방병원 한방내과) ;
  • 허래경 (원광대학교 광주한방병원 한방내과) ;
  • 장명준 (원광대학교 광주한방병원 한방내과) ;
  • 이인영 (원광대학교 광주한방병원 한방내과) ;
  • 송봉근 (원광대학교 광주한방병원 한방내과)
  • Received : 2010.11.15
  • Accepted : 2010.11.25
  • Published : 2010.12.30
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Abstract

Objective : Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes (MELAS) syndrome is a progressive neurodegenerative disorder. The typical presentation of patients with MELAS syndrome includes features such as mitochondrial encephalomyopathy, lactic acidosis, and stroke like episodes. Other features, such as seizures, diabetes mellitus, hearing loss, cardiac disease, short stature, endocrinopathies, exercise intolerance, and neuropsychiatric dysfunction are clearly part of the disorder. Approximately 80% of patients with the clinical characteristics of MELAS syndrome have a genetic mutation. This progressive disorder is reported to have a high morbidity and mortality. This case report is intended to estimate clinical effects of oriental meedicinal treatment of MELAS syndrome. Methods : A 44 year old female patient diagnosed as MELSA syndrome was treated with general oriental medicinal therapy including acupuncture, moxibustion, cupping, pharmacupunture and herbal medication in 20XX in Wonkwang Medical Center Gwangju. And the changes in symptoms and signs were evaluated as time dependently. Results : Although there is currently no curable treatment and MEALS syndrome is tend to progress, our treatment showed improvement in general weakness, gait disturbance and pain in the patient. Conclusion : Our case report suggests that various oriental medicinal treatment could be effective for improvement of MELAS syndrome and may represent a new potential therapeutic approach to control the disease. It could be applied to improve general condition, prevent relapse, enhance the quality of life and reduce complaints in the patient.

Keywords

References

  1. Paclakis SG, Phillips PC, DiMauro S, et, al. Mitochondrial Myopathy, Encephalopathy, Lactic acidosis, and stroke-like Episode : A Distinctive Clinical syndrome. Ann Neurol. 1984;16:481-8. https://doi.org/10.1002/ana.410160409
  2. DiMauro S, Bonila E, Zeviani M, et al. Mitochondrial myopathies. Ann Neurol. 1985;17:521-38. https://doi.org/10.1002/ana.410170602
  3. Larsson NG, Clayton DA. Molecular genetic aspects of human mitichondrial disdorders. Annu Rev Genet. 1995;29:151-78. https://doi.org/10.1146/annurev.ge.29.120195.001055
  4. 洪元植. 精交黃帝內徑素問. 서울:東洋醫學硏究院出版部. 1975:16, 112, 166-8.
  5. Kwak Joong Moon, Oh Min Suk. The Literary study on Flaccidity-syndrome. 대전대학교 한의 학연구소 논문집. 2000;9(1):661-89.
  6. Anderson S, Nankier AT, Narrell BG, de Bruijin MH, Coulson AR, Drouin J, et al. Sequence and organization of the human mitochondrial genome. Nature. 1981;90:457-65.
  7. Giles RE, Blanc H, Cann HM, Wallace DC. Maternal ingeritance of human mitochondrial DNA. Proc Natl Acad Sci USA. 1980;77:6715-9. https://doi.org/10.1073/pnas.77.11.6715
  8. Flier JS, Underhill LH. Mitichondrial DNA and disease. New Engl. J Medicine. 1995;7:638-44.
  9. Holt IJ, Harding AE, morgan-Hughes JA. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature. 1988;331:717-9. https://doi.org/10.1038/331717a0
  10. Wallace DC, Singh G, Lott MT et al. Mitochondrial DNA mutation associated with Lever's hereditary optic neuropathy. Sience. 1988;242:1427-30. https://doi.org/10.1126/science.3201231
  11. Rustin P, Chretien D, Bourgeron T et al. Assessment of the mitochondrial respiratory chain. Lancet. 1991;338:60.
  12. Goto YI, Nonaka I, Horai S. A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature. 1990;348:651-3. https://doi.org/10.1038/348651a0
  13. Fische-Ghodisian N. Mitochondrial deafness. Ear Hear. 2003;24:303-13.
  14. Wang Z, Liu S, Yang Y, Yuan Y, Wu L, Qi Y, Chen Q. detection of A3234G point mutation in mitichondrial DNA from 10 cases of MELAS. Chin Med J. 2002;115:995-7.
  15. Allard JC et al. CT and MRI of MELAS syndrome. Am J Neuroradio. 1988;l9:1234-8.
  16. Penn AMW, Lee JWK, Thuiller, er al. MELAS syndrome with mitochondrial tRNALeu(UUR) mutation: Correlation of clinical state, nerve conduction, and muscle 31P magnetic resonance spectroscopy during treatment with nicotinamide and riboflabin. Neurol. 1992;42:2147-52. https://doi.org/10.1212/WNL.42.11.2147
  17. 한방재활의학과학회. 한방재확의학. 서울:군자출판사. 2003:135-8.
  18. 王氷. 新編黃帝內經素問. 서울:대성문화사. 1994: 271-4.
  19. 張景岳. 新景岳全書上. 서울:아울로스출판사. 1994:708-11.
  20. Kim DH. Illustrations Kyokam Sa-am Do-in Acupucture. Busan:Sogang. 2002:475-80.
  21. 李濟馬. 四象醫學原論서울:행림풀판사. 1974: 361-71.
  22. Chun CK, Nam SS, Park DS. Effects of Chaenomelis fructus Herbar Acupuncture on Muscle Fiber in Muscle Atrophy Rat induced by Hindimb Suspension. JKAMS. 2001;18(1): 170-85.
  23. Fadic R, Johns DR. Treatment of the mitochondrial encephalomyophaties. In : Beal MF, Bodis-wollner I, Howell N(eds.): "Mitichondrial and Free Radicals in Neurodegenerative Diseases." New York, USA:Wiley-Liss, 1997;537-55.
  24. Moon JY. Effects of Hwangrynhaedok-tang on DNA Damage, Antioxidant Enzymes Expression and Acetylcholinesterase Activity. Kor. J. Herbology. 2007;22(1):7-12.