Mycobiology

The Korean Society of Mycology (한국균학회)
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Extraction and Characteristics of Anti-obesity Lipase Inhibitor from Phellinus linteus

  • Lee, Jong-Kug (Chungnam Agricultural Research and Extension Services) ;
  • Jang, Jeong-Hoon (Department of Life Science and Genetic Engineering, Paichai University) ;
  • Lee, Jong-Tae (Central Research Institute, Korea Ginseng Corporation) ;
  • Lee, Jong-Soo (Department of Life Science and Genetic Engineering, Paichai University)
  • Published : 2010.03.31
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Abstract

To develop a potent anti-obesity lipase inhibitor from mushroom, the lipase inhibitory activities of various mushroom extracts were determined. Methanol extracts from Phellinus linteus fruiting body exhibited the highest lipase inhibitory activity (72.8%). The inhibitor was maximally extracted by treatment of a P. linteus fruiting body with 80% methanol at $40^{\circ}C$ for 24 hr. After partial purification by systematic solvent extraction, the inhibitor was stable in the range of $40\sim80^{\circ}C$ and pH 2.0~9.0. In addition to lipase inhibitory activity, the inhibitor showed 59.4% of superoxide dismutase-like activity and 56.3% of acetylcholinesterase inhibitory activity.

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References

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