Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Effects of Dietary Betaine on the Secretion of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-1 and -3 in Laying Hens

  • Choe, H.S. (Division of Animal Science & Biotechnology, College of Agriculture and Life Science, Chonbuk National University) ;
  • Li, H.L. (College of Agriculture, Yanbian University) ;
  • Park, J.H. (Division of Animal Science & Biotechnology, College of Agriculture and Life Science, Chonbuk National University) ;
  • Kang, C.W. (Department of Physiology, College of Veterinary Medicine, Chonbuk National University) ;
  • Ryu, Kyeong Seon (Division of Animal Science & Biotechnology, College of Agriculture and Life Science, Chonbuk National University)
  • Received : 2007.11.07
  • Accepted : 2008.12.24
  • Published : 2010.03.01
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Abstract

The principal objective of this experiment was to determine the effects of dietary betaine on IGF-I, IGFBP-3 and IGFBP-1 secretion and IGF-I mRNA gene expression in the serum and liver of laying hens. A total of 72 ISA-Brown laying hens were fed with four different levels of betaine (0, 300, 600, 1,200 ppm) based on a corn-soybean meal diet containing 2,800 kcal/kg of metabolizable energy (ME) and 16% crude protein (CP) for four weeks. The results indicated significantly higher serum and liver IGF-I concentrations in the laying hens fed with 600 and 1,200 ppm betaine (p<0.05) compared to controls. IGF-I gene expression in liver showed a statistically correlated increase in 600 and 1,200 ppm betaine-fed groups as compared to the controls (p<0.05). Serum IGFBP-3 concentrations were elevated significantly in the groups fed 600 ppm of betaine. However, the secretion of IGFBP-1 in the liver of laying hens fed on 600 and 1,200 ppm of betaine was significantly lower than in the controls (p<0.05). The results of this experiment showed that dietary betaine supplementation plays a pivotal role in changes of the IGFs system in laying hens.

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References

  1. Amy, E. L., B. Patrice, H. C. Anne, A. C. Joseph and K. R. Michael. 1998. Regulation of experimental autoimmune encephalomyelitis with insulin-like growth factor (IGF-1) and IGF-1/IGF-binding protein-3 complex (IGF-1/IGFBP3). J. Clin. Invest. 101:1797-1804 https://doi.org/10.1172/JCI1486
  2. Barak, A. J. and D. J. Tuma. 1983. Betaine, metabolic by-product or vital. methylating agent?. Life Sci. 32:771-774 https://doi.org/10.1016/0024-3205(83)90311-9
  3. Barak, A. J., H. C. Beckenhauer and D. J. Tuma. 1994. Sadenosylmethionine generation and prevention of alcoholic fatty liver by betaine. Alcohol 11:501-503 https://doi.org/10.1016/0741-8329(94)90075-2
  4. Baxter, R. C. 1993. Circulating binding proteins for the insulinlike growth factors. Trends Endocrinol. Metab. 4:91-96 https://doi.org/10.1016/1043-2760(93)90085-S
  5. Froesch, E. R., C. Schmid, J. Schwander and J. Zapf. 1985. Actions of insulin-like growth factors. Ann. Rev. Phys. 47:443-467 https://doi.org/10.1146/annurev.ph.47.030185.002303
  6. Hill, R. A. and J. M. Pell. 1998. Regulation of insulin-like growth factor I (IGF-I) bioactivity in vivo: Further characterization of an IGF-I-enhancing antibody. Endocrinology 139:1278-1287 https://doi.org/10.1210/en.139.3.1278
  7. Honarbakhsh, S., M. Zaghari and M. Shivazad. 2007. Can exogenous betaine be an effective osmolyte in broiler chicks under water salinity stress?. Asian-Aust. J. Anim. Sci. 20:1729-1737
  8. Hossenlopp, P., B. Segovia, C. Lassarre, M. Roghani, M. Bredon and M. Binoux. 1990. Evidence of enzymatic degradation of insulin-like growth factor-binding proteins in the 150k complex during pregnancy. J. Clin. Endocrinol. Metab. 71:797-805 https://doi.org/10.1210/jcem-71-4-797
  9. Jones, J. I. and D. R. Clemmons. 1995. Insulin-like growth factors and their binding proteins: biological actions. Endocr. Rev. 16:3-34
  10. Kasai, K., H. Suzuki, T. Nakamura, H. Shiina and S. I. Shimoda. 1980. Glycine stimulated growth hormone release in man. Acta Endocrinol. (Copenhagen) 93:283-286
  11. Kettunen, H., K. Tiihonen, S. Peuranen, M. T. Saarinen and J. C. Remus. 2001. Dietary betaine accumulates in the liver and intestinal tissue and stabilizes the intestinal epithelial structure in healthy and coccidian-infected broiler chicks. Comp. Biochem. Physiol. A 130:759-769 https://doi.org/10.1016/S1095-6433(01)00410-X
  12. Kidd, M. T., P. R. Ferket and J. D. Garlich. 1997. Nutritional and osmoregulatory functions of betaine. World's Poult. Sci. 53:125-139 https://doi.org/10.1079/WPS19970013
  13. Lee, C. Y. and D. M. Henricks. 1990. Comparisions of various acidic treatments of bovine serum on insulin-like growth factor-I immunoreactive and binding activity. Endocrinology 127:139-148 https://doi.org/10.1677/joe.0.1270139
  14. Lee, P. D. K., C. Conover and D. R. Powell. 1993. Regulation and function of insulin-like growth factor-binding protein-I. Proc. Soc. Exptl. Biol. Med. 204:4-29
  15. Lee, W. H., R. R. Bowsher, J. M. Apahy, M. C. Smith and D. P. Henry. 1991. Measurement of IGF-II in physiological fluid and tissues. II. Extraction in quantification in rat tissues. Endocrinology 128:815-822 https://doi.org/10.1210/endo-128-2-815
  16. Matstumoto, T., S. E. Gargosky, K. Iwasaki and R. G. Resanfeld. 1996. Identification and charaterization of IGFs, IGFBPs and IGF proteases in human synovial fluid. J. Clin. Endocr. Metab. 81:150-155 https://doi.org/10.1210/jc.81.1.150
  17. Nocianitri, K. A., S. Sakakibara, T. Kanno, H. Kikuchi, M. Kurasaki and Y. Aoyama. 2002. Influence of dietary methionine level on the liver metallothionein mRNA level in rats. Biosci. Biotechnol. Biochem. 66:2465-2470 https://doi.org/10.1271/bbb.66.2465
  18. Olivecrona, H., A. Hilding, C. Ekstrom, H. Barle, B. Nyberg, C. Moller, P. J. Delhanty, R. C. Baxter, B. Angelin, T. J. Ekstrom and M. Tally. 1999. Acute and short-term effects of growth hormone on insuline-like growth factors and their binding proteins: serum levels and hepatic messenger ribonucleic acid responses in humans. J. Clin. Endocr. Metab. 84:553-560 https://doi.org/10.1210/jc.84.2.553
  19. Park, J. H., C. W. Kang and K. S. Ryu. 2006. Effects of feeding betaine on performance and blood hormone in laying hens. Kor. J. Poult. Sci. 33(4):323-328
  20. Rechler, M. M. 1993. Insulin-like growth factor binding proteins. Vitam. Horm. 47:1-114 https://doi.org/10.1016/S0083-6729(08)60444-6
  21. Salobir, B., J. Prezelj, H. Meden-Vrtovec, A. Kocijancic and J. Osredkar. 1996. Insulin-like growth factor binding protein-3 (IGFBP-3) serum concentrations and ovarian responsiveness in in-vitro fertilization. Hum. Rep. 11:2208-2210 https://doi.org/10.1093/oxfordjournals.humrep.a019077
  22. Saunderson, C. L. and J. MacKinlay. 1990. Changes in body-weight, composition and hepatic enzyme activities in response to dietary methionine, betaine and choline levels in growing chicks. Br. J. Nutr. 63:339-349 https://doi.org/10.1079/BJN19900120
  23. Stewart, C. E. and P. Rotwein. 1996. Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiol. Rev. 76:1005-1026
  24. Zulkifli, I., S. A. Mysahra and L. Z. Jin. 2004. Dietary supplementation of betaine (betafin) and response to high temperature stress in male broiler chickens. Asian-Aust. J. Anim. Sci. 17:244-249

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