Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Relationship among Bone Mineral Density, Body Composition, and Metabolic Syndrome Risk Factors in Females

  • Kim, Tai-Jeon (Department of Biomedical Laboratory Sciences, College of Health Sciences Eulji University) ;
  • Cha, Byung-Heun (Department of Biomedical Laboratory Sciences, College of Health Sciences Eulji University) ;
  • Shin, Kyung-A (Department of Laboratory Medicine Bundang Jesaeng Hospital)
  • ;
  • ;
  • 신경아 (분당제생병원 진단검사의학과)
  • Received : 2010.07.19
  • Accepted : 2010.09.01
  • Published : 2010.09.30
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Abstract

Osteoporosis is a disease that increases the fracture rates and a major cause of increased mortality and morbidity in the elderly people. This study is to determine which components of body composition and metabolic syndrome risk factors are important to bone health, we analysed the relationship among bone mineral density (BMD), body composition and metabolic syndrome risk factors in females. Totally 630 females participated in a medical check-up program (mean age 47 years) were selected for this study. Body composition analysis was performed by segmental bioelectrical impedance method, muscle mass, and percent body fat were measured. We also measured metabolic syndrome risk factors including abdominal obesity, HDL-cholesterol, triglyceride, blood pressure and fasting glucose level. Metabolic syndrome was defined by NCEP-ATP III criteria. The lumbar spine and femoral neck BMD were measured using the dual energy X-ray absorptiometry. Osteopenia and osteoporosis were observed in 180 and 51 persons, respectively. Muscle mass and HDL-cholesterol decreased in osteopenia and osteoporosis groups compared to the control group, and the grade was shown progressively by the symptoms. Significant positive correlation between BMD and muscle mass was observed. Multi variable regression analyses showed that % body fat and muscle mass were independent predictors of BMD after adjustment of age, height and weight. In conclusion, the BMD showed negative correlation with the metabolic and body composition was associated with BMD.

Keywords

References

  1. Arimatsu M, Kitano T, Kitano N, Futatsuka M. Correlation between bone mineral density and body composition in Japanese females aged 18-40 years with low forearm bone mineral density. Environ Health Prev Med. 2009. 14: 46-51. https://doi.org/10.1007/s12199-008-0056-7
  2. Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab. 2003. 88: 2404-2411. https://doi.org/10.1210/jc.2003-030242
  3. Expert panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment PanelIII). JAMA. 2001. 285: 2486-2497. https://doi.org/10.1001/jama.285.19.2486
  4. Felson DT, Zhang Y, Hannan MT, Anderson JJ. Effects of weight and body mass index on bone mineral density in men and women: the Framingham study. J Bone Miner Res. 1993.8: 567-573.
  5. Genaro PS, Pereira GA, Pinheiro MM, Szejnfeld VL, Martini LA. Influence of body composition on bone mass in postmenopausal osteoporotic women. Arch Gerontol Geriatr. 2010. in press.
  6. Gohlke-Barwolf C. Coronary artery disease - is menopause a risk factor?. Basic Res Cardiol. 2000. 95: 177-183.
  7. Hwang DK, Choi HJ. The relationship between low bone mass and metabolic syndrome in Korean women. Osteoporos Int. 2010. 21: 425-431.
  8. Jankowska EA, Rogucka E, Medras M. Are general obesity and visceral adiposity in men linked to reduced bone mineral content resulting from normal ageing? A population-based study. Andrologia. 2001. 33: 384-389. https://doi.org/10.1046/j.1439-0272.2001.00469.x
  9. Jin MR, Kim JM, Kim HS, Chang NS. Associations of lifestyle behaviors, dietary habits and bone mineral density in men aged 50 years and older. Nutr Res Pract. 2009. 42: 59-67.
  10. Kim CJ, Oh KW, Phee EJ, Kim KH, Jo SK, Jung CH, Won JC, Park CY, Lee WY, Park SW, Kim sw. Relationship between body composition and bone mineral density (BMD) in perimenopausal Korean women. Clin Endocrinol(Oxf). 2009. 71: 18-26. https://doi.org/10.1111/j.1365-2265.2008.03452.x
  11. Kim SH, O SD, Park YS. Relation of regular physical activity to body composition and bone mineral density in postmenopausal women. J Korean Physical Education Association for Girls and Women 2003. 17: 65-74.
  12. Kinjo M, Setoguchi S, Solomon DH. Bone mineral density in adults with the metabolic syndrome: analysis in a population based U.S. sample. J Clin Endocrinol Metab. 2007. 92: 4161-4164. https://doi.org/10.1210/jc.2007-0757
  13. Korea ministry of Health & Welfare. National health and nutrition survey. 2005. 38-43.
  14. Lekamwasam S, Weerarathna T, Rodrigo M, Arachchi WK, Munidasa D. Osteoporosis and cardiovascular risk among premenopausal women in Sri Lanka. J Clin Densitom. 2009. 12: 245-450. https://doi.org/10.1016/j.jocd.2009.02.001
  15. Lim YW, Sun DH, Kim YS. Osteoporosis: Pathogenesis and fracture prevention. J Korean Hip Society. 2009. 21: 6-16. https://doi.org/10.5371/jkhs.2009.21.1.6
  16. Lindheim SR, Buchanan TA, Duffy DM, Vijod MA, Kojima T, Stanczyk FZ, Lobo RA Comparison of estimates of insulin sensitivity in pre- and postmenopausal women using the insulin tolerance test and the frequently sampled intravenous glucose tolerance test. J Soc Gynecol Investig. 1994. 1: 150-154. https://doi.org/10.1177/107155769400100210
  17. Lu LJ, Nayeem F, Anderson KE, Grady JJ, Nagamani M. Lean body mass, not estrogen or progesterone, predicts peak bone mineral density in premenopausal women. J Nutr. 2009. 139: 250-256. https://doi.org/10.3945/jn.108.098954
  18. Morin S, Tsang JF, Leslie WD. Weight and body mass index predict bone mineral density and fractures in women aged 40 to 59 years. Osteoporos Int. 2009. 20: 363-370. https://doi.org/10.1007/s00198-008-0688-x
  19. Nguyen TV, Sambrook PN, Eisman JA. Bone loss, physical activity, and weight change in elderly women: the Dubbo osteoporosis epidemiology study. J Bone Miner Res. 1998. 13: 1458-1467. https://doi.org/10.1359/jbmr.1998.13.9.1458
  20. Park JS, Park HD, Yun JW, Jung CH, Lee YW, Kim SW. Prevalence of the metabolic syndrome as defined by NCEPATP IIl among the urban Korean population. Korean J Med. 2002. 63: 290-298.
  21. Park KK, Kim SJ, Moon ES. Association between bone mineral density and metabolic syndrome in postmenopausal Korean women. Gynecol Obstet Invest. 2010. 69: 145-152. https://doi.org/10.1159/000264665
  22. Pasquali R, Casimirri F, Labate AM, Tortelli O, Pascal G, Anconetani B, Gatto MR, Flarnia R, Capelli M, Barbara L. Body weight, fat distribution and the menopausal status in women. The VMH Collaborative Group. Int J Obes Relat Metab Disord. 1994. 18: 614-621.
  23. Premaor MO, Pilbrow L, Tonkin C, Parker R, Compston J. Obesity and fractures in postmenopausal woman. J Bone Miner Res. 2010.25: 292-297. https://doi.org/10.1359/jbmr.091004
  24. Song JY, Song R, Jo HH, Kwon DJ, Lew YO, Lim YT, Kim JH, Kim JH, Kim MR. The importance of lean body mass for bone mineral density in postmenopausal women. J Korean Soc Menopause. 2009. 15: 48-55. https://doi.org/10.1258/mi.2009.009024
  25. Sowers M, Kshirsagar A, Crutchfield M, Updike S. Body composition, age and femoral bone mass of young adult women. Ann Epidemiol. 1991. 1: 245-454. https://doi.org/10.1016/1047-2797(91)90003-U
  26. Stolk RP, Van Daele PL, Pols HA, Burger H, Hofman A. Birkenhager JC, Lamberts SW, Grobbee DE. Hyperinsulinemia and bone mineral density in an elderly population: The Rotterdam Study. Bone. 1996. 18: 545-549. https://doi.org/10.1016/8756-3282(96)00079-8
  27. Tseng YH, Huang KC, Liu ML, Shu WT, Sheu WH. Association between metabolic syndrome (MS) and bone mineral loss: a cross-sectional study in Puli Township in Taiwan. Arch Gerontol Geriatr. 2009. 49: 37-40. https://doi.org/10.1016/S0167-4943(09)70011-1
  28. World health organization. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1994. 834: 1-129.
  29. World health organization. Obesity: preventing and managing, the global epidemic. report of a WHO consultation. World Health Organ Tech Rep Ser. 2000. 894: 1-253.
  30. Zillikens MC, Uitterlinden AG, van Leeuwen JP, Berends AL, Henneman P, van Dijk KW, Oostra BA, van Duijn CM, Pols HA, Rivadeneira F. The role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral density. Calcif Tissue Int. 2010. 86: 116-125. https://doi.org/10.1007/s00223-009-9319-6