Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Anti-inflammatory and radical scavenging properties of Verbena officinalis

  • Shim, Hwan-Ki (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Kim, Seong-Yeol (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Kim, Bo-Rim (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Cho, Jae-Park (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Park, Yae-Jeong (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Ji, Won-Geun (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Cha, Dong-Seok (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Jeon, Hoon (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
  • Received : 2010.11.05
  • Accepted : 2010.12.16
  • Published : 2010.12.31
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Abstract

Verbena officinalis (Verbenaceae) has been used as herbal medicine or health supplement in both Western and Eastern countries for centuries. In the present study, we examined the anti-inflammatory and antioxidant activities of the methylene chloride fraction of V. officinalis (VMC). To elucidate the anti-inflammatory properties of VMC, we investigated the inhibition effects of nitric oxide production in interferon-gamma (IFN-$\gamma$) and lipopolysaccharide-stimulated mouse peritoneal macrophages. VMC suppressed nitric oxide production, inducible nitric oxide synthase and cyclooxygenase-2 expression dose-dependently without notable cytotoxicity. In various radical scavenging assays, VMC exhibited strong scavenging effect on DPPH radical, superoxide radical, nitric oxide radical and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radical. VMC also showed potent reducing power. These findings strongly suggest that VMC may be beneficial in oxidative stress-mediated inflammatory disorders.

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References

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