Dementia and Neurocognitive Disorders (대한치매학회지)

Korean Dementia Association (대한치매학회)
권호 표지

Analysis of Circulating CD34-positive Cells in Alzheimer' Disease

알츠하이머병 환자의 말초혈액 내 CD34 양성세포 수치의 변화

  • Lee, Soon-Tae (Department of Neurology, Seoul National University Hospital) ;
  • Chu, Kon (Department of Neurology, Seoul National University Hospital) ;
  • Jung, Keun-Hwa (Department of Neurology, Seoul National University Hospital) ;
  • Sim, Ji-Young (Department of Neurology, Seoul National University Hospital) ;
  • Oh, Min-Jeong (Department of Neurology, Seoul National University Hospital) ;
  • Park, Myoung-Hee (Department of Laboratory Medicine, Seoul National University Hospital) ;
  • Kim, Man-Ho (Department of Neurology, Seoul National University Hospital)
  • 이순태 (서울대학교병원 신경과) ;
  • 주건 (서울대학교병원 신경과) ;
  • 정근화 (서울대학교병원 신경과) ;
  • 심지영 (서울대학교병원 신경과) ;
  • 오민정 (서울대학교병원 신경과) ;
  • 박명희 (서울대학교병원 진단검사의학과) ;
  • 김만호 (서울대학교병원 신경과)
  • Published : 2010.09.30
⟨ Previous Next ⟩

Abstract

Background: Circulating CD34-positive cells constitute the endothelial progenitor cell population, differentiate into endothelial cells, and contribute to mammalian brain regeneration. Given the vascular endothelial pathogenesis of Alzheimer' disease (AD), we investigated the levels of CD34+ cells in AD patients. Methods: Sixty-six consecutive patients with probable AD (clinical dementia rating scale 1) and 22 age-matched control subjects were enrolled. CD34+ cells were counted in their peripheral blood samples and analyzed in comparison with their clinical characteristics. Results: The AD patients had significantly lower numbers of CD34-positive cells than control subjects. However, the number of CD34-positive cells was not correlated with clinical characteristics of AD patients, including Mini Mental State Examination (MMSE) score, Framingham risk score, body-mass index, and changes in MMSE during 3 months. Conclusions: AD patients have diminished circulating CD34-positive cells, suggesting the reduced regenerative support from the peripheral blood in AD patients.

Keywords

References

  1. Benarroch EE. Neurovascular unit dysfunction: a vascular component of Alzheimer disease? Neurology 2007; 68: 1730-2 https://doi.org/10.1212/01.wnl.0000264502.92649.ab
  2. Zlokovic BV. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci 2005; 28: 202-8 https://doi.org/10.1016/j.tins.2005.02.001
  3. Weller RO, Subash M, Preston SD, Mazanti I, Carare RO. Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Brain Pathol 2008; 18: 253-66
  4. Lee ST, Jung KH, Lee YS. Decreased vasomotor reactivity in Alzheimer's disease. J Clin Neurol 2007; 3: 18-23 https://doi.org/10.3988/jcn.2007.3.1.18
  5. Breteler MM. Vascular risk factors for Alzheimer's disease: an epidemiologic perspective. Neurobiol Aging 2000; 21: 153-60
  6. Hristov M, Erl W, Weber PC. Endothelial progenitor cells: mobilization, differentiation, and homing. Arterioscler Thromb Vasc Biol 2003; 23: 185-9
  7. ahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964-7 https://doi.org/10.1126/science.275.5302.964
  8. Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000; 290: 1779-82 https://doi.org/10.1126/science.290.5497.1779
  9. Cogle CR, Yachnis AT, Laywell ED, Zander DS, Wingard JR, Steindler DA, et al. Bone marrow transdifferentiation in brain after transplantation: a retrospective study. Lancet 2004; 363: 1432-7 https://doi.org/10.1016/S0140-6736(04)16102-3
  10. Maler JM, Spitzer P, Lewczuk P, Kornhuber J, Herrmann M, Wiltfang J. Decreased circulating cd34(+) stem cells in early alzheimer's disease: Evidence for a deficient hematopoietic brain support? Mol Psychiatry 2006; 11: 1113-5 https://doi.org/10.1038/sj.mp.4001913
  11. Taguchi A, Matsuyama T, Nakagomi T, Shimizu Y, Fukunaga R, Tatsumi Y, et al. Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment. J Cereb Blood Flow Metab 2008; 28: 445-9 https://doi.org/10.1038/sj.jcbfm.9600541
  12. Stellos K, Panagiota V, Sachsenmaier S, Trunk T, Straten G, Leyhe T, et al. Increased circulating progenitor cells in Alzheimer's disease patients with moderate to severe dementia: evidence for vascular repair and tissue regeneration? J Alzheimers Dis 2010; 19: 591-600 https://doi.org/10.3233/JAD-2010-1261
  13. Lee ST, Chu K, Jung KH, Park HK, Kim DH, Bahn JJ, et al. Reduced circulating angiogenic cells in Alzheimer disease Neurology 2009; 72: 1858-63 https://doi.org/10.1212/WNL.0b013e3181a711f4
  14. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDSADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-44 https://doi.org/10.1212/WNL.34.7.939
  15. Schmidt-Lucke C, Rossig L, Fichtlscherer S, Vasa M, Britten M, Kamper U, et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 2005; 111: 2981-7 https://doi.org/10.1161/CIRCULATIONAHA.104.504340
  16. Kang HJ, Kim HS, Zhang SY, Park KW, Cho HJ, Koo BK, et al. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet 2004; 363: 751-6 https://doi.org/10.1016/S0140-6736(04)15689-4
  17. Taguchi A, Matsuyama T, Moriwaki H, Hayashi T, Hayashida K, Nagatsuka K, et al. Circulating CD34-positive cells provide an index of cerebrovascular function. Circulation 2004; 109: 2972-5 https://doi.org/10.1161/01.CIR.0000133311.25587.DE
  18. Thum T, Hoeber S, Froese S, Klink I, Stichtenoth DO, Galuppo P, et al. Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1. Circ Res 2007; 100: 434-43 https://doi.org/10.1161/01.RES.0000257912.78915.af
  19. Dimmeler S, Aicher A, Vasa M, Mildner-Rihm C, Adler K, Tiemann M, et al. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J Clin Invest 2001; 108: 391-7 https://doi.org/10.1172/JCI13152
  20. Song IU, Kim JS, Kim YI, Eah KY, Lee KS. Clinical significance of silent cerebral infarctions in patients with Alzheimer disease. Cogn Behav Neurol 2007; 20: 93-8 https://doi.org/10.1097/WNN.0b013e31805d859e