Total Hip Arthroplasty for Osteonecrosis of the Femoral Head Following Cardiac Transplantation - A Case Report -

심장이식 환자에서 발생한 대퇴 골두의 무혈성 괴사 - 증례보고 -

  • Kim, Hyung-Won (Center for Joint Disease, Chonnam National University Hwasun Hospital) ;
  • Yoon, Taek-Rim (Center for Joint Disease, Chonnam National University Hwasun Hospital) ;
  • Cho, Yong-Jin (Center for Joint Disease, Chonnam National University Hwasun Hospital)
  • 김형원 (전남대학교 의과대학 정형외과학교실, 화순전남대병원 관절센터) ;
  • 윤택림 (전남대학교 의과대학 정형외과학교실, 화순전남대병원 관절센터) ;
  • 조용진 (전남대학교 의과대학 정형외과학교실, 화순전남대병원 관절센터)
  • Published : 2010.06.30

Abstract

Cardiac transplantation has become the treatment of choice for end stage heart disease, and the long-term survival rates of cardiac transplant patients continue to improve, due to the continued improvements made in operation methods and postoperative immunological therapies. However, the incidences of disabling orthopedic complications, such as, osteopenia, osteoporosis, fractures, and osteonecrosis, have been increased by the postoperative administrations of steroids and immunosuppressive agents. Accordingly, several orthopedic surgeons have evaluated treatments for these complications, and a number of reports have been issued on osteonecrosis after cardiac transplantation. However, all of these reports have been issued is the US and European countries, and in particular, no report has been published on osteonecrosis following cardiac transplantation in an Asian patient. In this report, the authors report the case of a patient who underwent total hip arthroplasty due to osteonecrosis of the femoral head after cardiac transplantation.

심장 이식술은 말기 심장 질환에서 가장 좋은 치료 방침이며, 수술 술기의 발달과 술 후 면역요법의 발전으로 심장 이식술 후 생존 기간은 점차 늘어나고 있다. 하지만 면역 요법으로 이용되는 스테로이드나 면역억제제의 영향으로 골감소증, 골다공증, 골절, 골괴사와 같은 정형외과 영역에서의 합병증은 더욱 증가하고 있는 실정이다. 미국 또는 유럽에서 심장 이식술 후 발생한 골괴사에 대한 몇몇 보고가 있었지만, 지금까지 아시아인에 대한 대퇴 골두 무혈성 괴사 보고는 없었다. 이에 저자는 심장 이식술 이후에 발생한 대퇴 골두 무혈성 괴사에 대한 고관절 인공 관절 전치환술증례를 문헌 고찰과 같이 보고하고자 한다.

Keywords

References

  1. Barnard CN. The operation. A human cardiac transplant: an interim report of a successful operation performed at Groote Schuur Hospital, Cape town. S Afr Med J. 1967;41:1271-4.
  2. Roussel JC, Baron O, P?rigaud C, et al. Outcome of heart transplants 15 to 20 years ago: graft survival, posttransplant morbidity, and risk factors for mortality. J Heart Lung Transplant. 2008;27:486-93. https://doi.org/10.1016/j.healun.2008.01.019
  3. Bradbury G, Benjamin J, Thompson J, Klees E, Copeland J. Avascular necrosis of bone after cardiac transplantation. Prevalence and relationship to administration and dosage of steroids. J Bone Joint Surg Am. 1994;76:1385-8.
  4. Danzig LA, Coutis RD, Resnick D. Avascular necrosis of the femoral head following cardiac transplantation: report of a case. Clin Orthop Relat Res. 1976;117:217-20.
  5. Fisher DE, Bickel WH, Holley KE, Ellefson RD. Corticosteroid-induced aseptic necrosis. II. Experimental study. Clin Orthop Relat Res. 1972;84:200-6. https://doi.org/10.1097/00003086-197205000-00033
  6. Li X, Jin L, Cui Q, Wang GJ, Balian G. Steroid effects on osteogenesis through mesenchymal cell gene expression. Osteoporos Int. 2005;16:101-8. https://doi.org/10.1007/s00198-004-1649-7
  7. Korompilias AV, Gilkeson GS, Seaber AV, Urbaniak JR. Hemorrhage and thrombus formation in early experimental osteonecrosis. Clin Orthop Relat Res. 2001;386:11-8. https://doi.org/10.1097/00003086-200105000-00003
  8. Leon JL, Resines C, Zafra A. Total hip arthroplasty in heart transplant patients. Acta Orthop Belg. 2007;73:720-8.
  9. Fisher DE, Bickel WH. Corticosteroid-induced avascular necrosis. A clinical study of seventy-seven patients. J Bone Joint Surg Am. 1971;53:859-73.
  10. Kanter SF, Samuel SI. Anesthesia for major operations on patients who have transplanted hearts, a review of 29 cases. Anesthesiology. 1977;46:65-8. https://doi.org/10.1097/00000542-197701000-00012
  11. Burton DS, Mochizuki RM, Halpern AA. Total hip arthroplasty in the cardiac transplant patient. Clin Orthop Relat Res. 1978;130:186-90.
  12. Isono SS, Woolson ST, Schurman DJ. Total joint arthroplasty for steroid-induced osteonecrosis in cardiac transplant patients. Clin Orthop Relat Res. 1987;217:201-8.
  13. Bockman RS, Weinerman SA. Steroid-induced osteoporosis. Orthop Clin North Am. 1990;21:97-107.
  14. Engh CA, Bobyn JD, Glassman AH. Porous-coated hip replacement. The factors governing bone ingrowth, stress shielding, and clinical results. J Bone Joint Surg Br. 1987; 69:45-55.
  15. Yoon TR, Park KS, Song EK, Seon JK, Seo HY. New twoincision minimally invasive total hip arthroplasty: comparison with the one-incision method. J Orthop Sci. 2009;14:155-60. https://doi.org/10.1007/s00776-008-1305-8