References
- Kim YM, Namkoong S, Yun YG, Hong HD, Lee YC, Ha KS, Lee H, Kwon HJ, Kwon YG, Kim YM. Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells. Biol Pharm Bull 2007;30:1674-1679. https://doi.org/10.1248/bpb.30.1674
- Tuttle KR, McGill JB, Haney DJ, Lin TE, Anderson PW; PKC-DRS, PKC-DMES, and PKC-DRS 2 Study Groups. Kidney outcomes in long-term studies of ruboxistaurin for diabetic eye disease. Clin J Am Soc Nephrol 2007;2:631-636. https://doi.org/10.2215/CJN.00840207
- Liao Z, Chen X, Wu M. Antidiabetic effect of flavones from Cirsium japonicum DC in diabetic rats. Arch Pharm Res 2010;33:353-362. https://doi.org/10.1007/s12272-010-0302-6
- Zhu CF, Peng HB, Liu GQ, Zhang F, Li Y. Beneficial effects of oligopeptides from marine salmon skin in a rat model of type 2 diabetes. Nutrition 2010;26:1014-1020. https://doi.org/10.1016/j.nut.2010.01.011
- Hamza N, Berke B, Cheze C, Agli AN, Robinson P, Gin H, Moore N. Prevention of type 2 diabetes induced by high fat diet in the C57BL/6J mouse by two medicinal plants used in traditional treatment of diabetes in the east of Algeria. J Ethnopharmacol 2010;128:513-518. https://doi.org/10.1016/j.jep.2010.01.004
- Stades AM, Heikens JT, Erkelens DW, Holleman F, Hoekstra JB. Metformin and lactic acidosis: cause or coincidence? A review of case reports. J Intern Med 2004;255:179-187. https://doi.org/10.1046/j.1365-2796.2003.01271.x
- Chiang CK, Ho TI, I, Peng YS, Hsu SP, Pai MF, Yang SY, Hung KY, Wu KD. Rosiglitazone in diabetes control in hemodialysis patients with and without viral hepatitis infection: effectiveness and side effects. Diabetes Care 2007;30:3-7. https://doi.org/10.2337/dc06-0956
- Kobayashi M, Iwata M, Haruta T. Clinical evaluation of pioglitazone. Nippon Rinsho 2000;58:395-400.
- Ryu JK, Lee T, Kim DJ, Park IS, Yoon SM, Lee HS, Song SU, Suh JK. Free radical-scavenging activity of Korean red ginseng for erectile dysfunction in non-insulin-dependent diabetes mellitus rats. Urology 2005;65:611-615. https://doi.org/10.1016/j.urology.2004.10.038
- Adiga S, Bairy KL, Meharban A, Punita IS. Hypoglycemic effect of aqueous extract of Trichosanthes dioica in normal and diabetic rats. Int J Diabetes Dev Ctries 2010;30:38-42. https://doi.org/10.4103/0973-3930.60011
- Gupta S, Sharma SB, Bansal SK, Prabhu KM. Antihyperglycemic and hypolipidemic activity of aqueous extract of Cassia auriculata L. leaves in experimental diabetes. J Ethnopharmacol 2009;123:499-503. https://doi.org/10.1016/j.jep.2009.02.019
- Han GC, Ko SK, Sung JH, Chung SH. Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice. J Agric Food Chem 2007;55:10641-10648. https://doi.org/10.1021/jf0722598
-
Park MW, Ha J, Chung SH. 20(S)-ginsenoside
$Rg_3$ enhances glucose-stimulated insulin secretion and activates AMPK. Biol Pharm Bull 2008;31:748-751. https://doi.org/10.1248/bpb.31.748 - Vuksan V, Sievenpiper JL. Herbal remedies in the management of diabetes: lessons learned from the study of ginseng. Nutr Metab Cardiovasc Dis 2005;15:149-160. https://doi.org/10.1016/j.numecd.2005.05.001
- Han KL, Jung MH, Sohn JH, Hwang JK. Ginsenoside 20S-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPARgamma) in 3T3-L1 adipocytes. Biol Pharm Bull 2006;29:110-113. https://doi.org/10.1248/bpb.29.110
- Trinh HT, Han SJ, Kim SW, Lee YC, C, Kim DH. Bifidus fermentation increases hypolipidemic and hypoglycemic effects of red ginseng. J Microbiol Biotechnol 2007;17:1127-1133.
- Cho WC, Chung WS, Lee SK, Leung AW, Cheng CH, Yue KK. Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats. Eur J Pharmacol 2006;550:173-179. https://doi.org/10.1016/j.ejphar.2006.08.056
- Luo JZ, Luo L. Ginseng on hyperglycemia: effects and mechanisms. Evid Based Complement Alternat Med 2009;6:423-427. https://doi.org/10.1093/ecam/nem178
- Chung SH, Choi CG, Park SH. Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice. Arch Pharm Res 2001;24:214-218. https://doi.org/10.1007/BF02978260
- Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 2002;51:1851-1858. https://doi.org/10.2337/diabetes.51.6.1851
- Xie JT, Wang CZ, Wang AB, Wu J, Basila D, Yuan CS. Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng. Acta Pharmacol Sin 2005;26:1104-1110. https://doi.org/10.1111/j.1745-7254.2005.00156.x
- Davydov VV, Molokovskii DS, Limarenko AIu. Efficacy of ginseng drugs in experimental insulin-dependent diabetes and toxic hepatitis. Patol Fiziol Eksp Ter 1990;(5):49-52.
- Lu JM, Yao Q, Chen C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol 2009;7:293-302. https://doi.org/10.2174/157016109788340767
- Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001;108:1167-1174. https://doi.org/10.1172/JCI13505
- Carling D. The AMP-activated protein kinase cascade: a unifying system for energy control. Trends Biochem Sci 2004;29:18-24. https://doi.org/10.1016/j.tibs.2003.11.005
- Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006;444:337-342. https://doi.org/10.1038/nature05354
- Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, Wierzbicki M, Verbeuren TJ, Cohen RA. Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes 2006;55:2180-2191. https://doi.org/10.2337/db05-1188
- Winder WW, Hardie DG. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol 1999;277(1 Pt 1):E1-E10.
- Yin HQ, Kim M, Kim JH, Kong G, Kang KS, Kim HL, Yoon BI, I, Lee MO, Lee BH. Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice. Toxicol Appl Pharmacol 2007;223:225-233. https://doi.org/10.1016/j.taap.2007.06.018
- Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002;109:1125-1131. https://doi.org/10.1172/JCI15593
- Hardie DG. The AMP-activated protein kinase pathway: new players upstream and downstream. J Cell Sci 2004;117(Pt 23):5479-5487. https://doi.org/10.1242/jcs.01540
- Xie JT, Mehendale SR, Wang A, Han AH, Wu JA, Osinski J, Yuan CS. American ginseng leaf: ginsenoside analysis and hypoglycemic activity. Pharmacol Res 2004;49:113-117. https://doi.org/10.1016/j.phrs.2003.07.015
- Jung CH, Seog HM, Choi IW, Choi HD, Cho HY. Effects of wild ginseng (Panax ginseng C. A. Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats. J Ethnopharmacol 2005;98:245-250. https://doi.org/10.1016/j.jep.2004.12.030
- Hardie DG, Carling D, Carlson M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 1998;67:821-855. https://doi.org/10.1146/annurev.biochem.67.1.821
- Hardie DG, Carling D. The AMP-activated protein kinase: fuel gauge of the mammalian cell? Eur J Biochem 1997;246:259-273. https://doi.org/10.1111/j.1432-1033.1997.00259.x
- Foretz M, Carling D, Guichard C, Ferre P, Foufelle F. AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes. J Biol Chem 1998;273:14767-14771. https://doi.org/10.1074/jbc.273.24.14767
- Crabb DW, Liangpunsakul S. Alcohol and lipid metabolism. J Gastroenterol Hepatol 2006;21 Suppl 3:S56-S60. https://doi.org/10.1111/j.1440-1746.2006.04582.x
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