Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)
- Volume 42 Issue 2
- /
- Pages.71-80
- /
- 2010
- /
- 1738-3544(pISSN)
- /
- 2288-1662(eISSN)
Patterns of Antimicrobial Resistance and Genotyping of Carbapenemase-producing Imipenem-nonsusceptible Pseudomonas aeruginosa
Imipenem 비감수성 Carbapenemase 생성 Pseudomonas aeruginosa에 의한 항생제 내성유형과 분자생물학적인 특성
- Lee, Jin-Hee (Department of Clinical Pathology, Kangwon National University Hospital) ;
- Lee, Gyusang (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University) ;
- Lim, Kwanhun (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University) ;
- Eom, Yong-Bin (Department of Biomedical Laboratory Science, Korea Nazarene University) ;
- Kim, Shin-Moo (Department of Clinical Laboratory Science, Wonkwang Health Science University) ;
- Kim, Jong-Bae (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University)
- 이진희 (강원대학교병원 진단검사의학과) ;
- 이규상 (연세대학교 임상병리학과) ;
- 임관훈 (연세대학교 임상병리학과) ;
- 엄용빈 (나사렛대학교 임상병리학과) ;
- 김신무 (원광보건대학 임상병리학과) ;
- 김종배 (연세대학교 임상병리학과)
- Received : 2010.06.05
- Accepted : 2010.12.10
- Published : 2010.08.30
Abstract
Pseudomonas aeruginosa are important nosocomial pathogens. Their resistance to carbapenem is increasing and causing concerns in Korea. An increasing prevalence of carbapenem resistance mediated by acquired carbapenemase is being reported. Over a 10 month-period from July 2007 to April 2008, 32 strains of imipenem-nonsusceptible P. auruginosa were isolated from Kangwon National University Hospital. To determine the prevalence and genotypes of the carbapenemase-producing clinical isolates, the antibiotic susceptibility was determined by Microscan Walkaway 96 SI System and the carbapenem activity was detected by the modified Hodge test and the imipenem-EDTA-SMA double-disk synergy test. The metallo-