Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Anti-Obesity Effects of Foeniculum fructus Water Extract

회향종자(Foeniculum fructus) 물 추출물의 항비만 효과

  • Seo, Dong-Joo (Dept. of Bio-Health Technology, Kangwon National University) ;
  • Kim, Jeong-Mi (Dept. of Bio-Health Technology, Kangwon National University) ;
  • Kim, Tae-Hyuk (Dept. of Bio-Health Technology, Kangwon National University) ;
  • Baek, Jong-Mi (Dept. of Bio-Health Technology, Kangwon National University) ;
  • Kim, Tae-Woo (Dept. of Bio-Health Technology, Kangwon National University) ;
  • Kim, Hyun-Sook (Well-being Bioproducts RIC Center, Kangwon National University) ;
  • Choe, Myeon (Dept. of Bio-Health Technology, Kangwon National University)
  • 서동주 (강원대학교 생명건강공학과) ;
  • 김정미 (강원대학교 생명건강공학과) ;
  • 김태혁 (강원대학교 생명건강공학과) ;
  • 백종미 (강원대학교 생명건강공학과) ;
  • 김태우 (강원대학교 생명건강공학과) ;
  • 김현숙 (강원대학교 강원웰빙특산물산업화지역혁신센터) ;
  • 최면 (강원대학교 생명건강공학과)
  • Received : 2010.08.03
  • Accepted : 2010.10.12
  • Published : 2010.11.30
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Abstract

We investigated the anti-obesity effects of Foeniculum fructus water extract on body weight, epididymal adipocyte size, plasma lipid levels and activities of key enzymes such as lipoprotein lipase (LPL), acyl-CoA synthetase (ACS) in high fat diet-induced obese mice. Experimental groups were normal diet group (ND), high fat diet group (HFD), high fat diet with 0.05% orlistat group (HFDO), and high fat diet with 0.5% Foeniculum fructus group (HFDF). Eleven-weeks feeding with HFD resulted in significant increase in lipid levels, body weight, liver and epididymal adipose tissue weight, compared with the ND group. Diet containing Foeniculum fructus water extract significantly reduced plasma total cholesterol, triglyceride and glucose concentrations as well as body weight, liver and epididymal adipose tissue weights. Plasma LDL cholesterol levels were significantly lower in the HFDF group than those in HFDO group. LPL activities elevated by a high fat diet were significantly decreased by Foeniculum fructus water extract administration. ACS activities decreased in the high fat diet group and markedly increased in the Foeniculum fructus water extract administered group. All things considered, Foeniculum fructus water extract efficiently inhibits the inflow of fatty acid into the cell, and activates metabolic process that uses fatty acids flowing as an energy source. Thus, Foeniculum fructus water extract may have great potential as a novel anti-obesity agent.

본 연구는 고지방식이에 의해 유도된 비만 마우스를 이용하여 회향종자 물 추출물을 급여한 후 체중, 간과 부고환 지방조직 무게, 혈중 지질 함량, 부고환 지방세포 크기 및 지방대사 관련 효소 활성의 변화를 측정하여 항비만 기능성 소재로서의 가능성 여부를 조사하였다. 실험군은 일반식이군 (ND), 고지방식이만을 섭취한 군(HFD), 고지방식이+0.05% orlistat군(HFDO), 고지방식이+0.5% 회향종자 물 추출물 섭취군(HFDF)으로 분류하였다. 고지방식이만을 섭취한 군은 일반식이군과 비교하여 체중, 간 무게, 부고환 지방조직무게, 혈장 지질 및 혈당 농도가 현저하게 증가하였다. 회향종자 물 추출물을 함유하고 있는 식이는 고지방식이만을 섭취한 군과 비교하여 체중 26.56%, 간 무게 22.56%, 부고환 지방조직 무게 29.19%, 혈당 16.58% 감소시켰으며, orlistat를 함유한 고지방식이군과 비교하여 혈장 총콜레스테롤과 중성지방의 수준은 유사하였다. 이로써 회향종자 물 추출물 섭취는 비만에 의해 유발되는 심혈관계 질환의 위험성을 줄여 줄 것으로 추정된다. 또한 부고환 지방세포 크기는 고지방식이만을 섭취한 군에서 일반식이군과 비교하여 현저히 증가하였고, 고지방식이에 의한 지방세포 크기 증가는 orlistat와 회향종자 물 추출물 섭취에 의해 억제되었다. 지방세포내로 지방산의 유입을 억제하는 LPD 효소 활성은 고지방식이만을 섭취한 군과 비교하여 일반식이군은 27.27%, orlistat 섭취군은 44.12%, 회향종자 물 추출물 섭취군은 33.41%로 억제되었으며, 지방이용을 자극하는 ACS 효소 활성은 일반식이군 330.99%, HFDO군 232.14%, 회향종자 물추출물 섭취군 187.39%로 현저하게 증가하였다. 결과적으로 회향종자 물 추출물 섭취는 체중 증가, 지방세포 형성 및 지방세포 크기, LPL 효소의 활성을 저해하고, ACS 효소의 활성을 증가시킴으로써 항비만 효과가 있을 것으로 사료된다.

Keywords

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