Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Effect of Stilbenoids on TNF-${\alpha}$-induced Adipokine Secretion

  • Ahn, Ji-Yun (Food Function Research Center, Korea Food Research Institute) ;
  • Lee, Hyun-Jung (Food Function Research Center, Korea Food Research Institute) ;
  • Kim, Sun-A (Food Function Research Center, Korea Food Research Institute) ;
  • Ha, Tae-Youl (Food Function Research Center, Korea Food Research Institute)
  • Published : 2009.10.31
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Abstract

Tumor necrosis factor (TNF)-${\alpha}$ is chronically elevated in adipose tissues of obese rodents and humans. Increased levels of TNF-${\alpha}$ have been implicated in both the induction of atherogenic adipokines, such as plasminogen activator inhibitor (PAI)-1, and the inhibition of the anti-atherogenic adipokine, adiponectin. In this study, we investigated the effects of trans-stilbene, piceatannol, rhaponticin, and piceid on the TNF-${\alpha}$-induced atherogenic changes of adipokines in 3T3-L1 cells. Exposure to TNF-${\alpha}$ for 24 hr increased PAI-1 secretion and decreased adiponectin secretion. Among stilbenoids, piceatannol significantly inhibited the increased secretion of PAI-1 induced by TNF-${\alpha}$. Adiponectin secretion decreased by TNF-${\alpha}$ was recovered after trans-stilbene and rhaponticin treatments. Our results showed that stilbenoids exerted different effects on TNF-${\alpha}$-induced changes in adipokines secretion in 3T3-L1 adipocytes according to their structural characteristics.

Keywords

References

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