대한한의정보학회지 (Journal of the Korean Institute of Oriental Medical Informatics)
- 제15권1호
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- Pages.57-66
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- 2009
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- 1598-4206(pISSN)
정양단(精養丹)의 항염증, 상처 치유효능에 대한 연구
Wound Healing-Enhancing and Anti-inflammatory effects of five Korean Traditional Herbal Medicines, Jeong Yang-dan
- 조가영 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
- 노호식 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
- 김은주 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
- 문은정 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
- 김지성 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
- 박혜윤 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
- 김덕희 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
- 김한곤 ((주)아모레퍼시픽 기술연구원 피부과학연구소)
- Cho, Ga-Young (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
- Rho, Ho-Sik (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
- Kim, Eun-Joo (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
- Moon, Eun-Jeong (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
- Kim, Ji-Seong (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
- Park, Hye-Yoon (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
- Kim, Duck-Hee (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
- Kim, Han-Gon (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER)
- 발행 : 2009.09.25
초록
Objectives : The aim of the present study is to evaluate the wound healing-enhancing and anti-inflammatory effects of Pinus densiflora, Cornus officinalis, Zingiber officinale, Ganoderma japonicum and Scutellaria baikalensison human keratinocyte, HaCaT cells. Methods : We adopted in vitro wound healing assay to measure the proliferation-and migration-enhancing effects in HaCaT cells. The expressions of cytokine genes were measured in HaCaT cells using real-time PCR analysis. Results : The extracts of Pinus densiflora, Cornus officinalis, Zingiber officinale, Ganoderma japonicum and Scutellaria baikalensis enhanced the proliferation and migration of HaCaTcells. The expression of keratinocyte growth factor receptor(FGFR2-IIIb) gene was also induced. The extracts inhibited iNOS, IL-
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