Journal of the Korean Institute of Oriental Medical Informatics (대한한의정보학회지)

The Korea Institute of Oriental Medical Informatics (대한한의정보학회)
권호 표지

Wound Healing-Enhancing and Anti-inflammatory effects of five Korean Traditional Herbal Medicines, Jeong Yang-dan

정양단(精養丹)의 항염증, 상처 치유효능에 대한 연구

  • Cho, Ga-Young (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
  • Rho, Ho-Sik (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
  • Kim, Eun-Joo (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
  • Moon, Eun-Jeong (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
  • Kim, Ji-Seong (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
  • Park, Hye-Yoon (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
  • Kim, Duck-Hee (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER) ;
  • Kim, Han-Gon (Skin Research Institute, AMOREPACIFIC CORPORATION/R&D CENTER)
  • 조가영 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
  • 노호식 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
  • 김은주 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
  • 문은정 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
  • 김지성 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
  • 박혜윤 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
  • 김덕희 ((주)아모레퍼시픽 기술연구원 피부과학연구소) ;
  • 김한곤 ((주)아모레퍼시픽 기술연구원 피부과학연구소)
  • Published : 2009.09.25
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The aim of the present study is to evaluate the wound healing-enhancing and anti-inflammatory effects of Pinus densiflora, Cornus officinalis, Zingiber officinale, Ganoderma japonicum and Scutellaria baikalensison human keratinocyte, HaCaT cells. Methods : We adopted in vitro wound healing assay to measure the proliferation-and migration-enhancing effects in HaCaT cells. The expressions of cytokine genes were measured in HaCaT cells using real-time PCR analysis. Results : The extracts of Pinus densiflora, Cornus officinalis, Zingiber officinale, Ganoderma japonicum and Scutellaria baikalensis enhanced the proliferation and migration of HaCaTcells. The expression of keratinocyte growth factor receptor(FGFR2-IIIb) gene was also induced. The extracts inhibited iNOS, IL-$1{\beta}$ and TNF-$\alpha$ gene expression. Conclusions : The extract of Pinus densiflora, Cornus officinalis, Zingiber officinale, Ganoderma japonicum and Scutellaria baikalensis has wound healing-enhancing effects and anti-inflammatory effects.

Keywords