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A Case of Infantile Meningioangiomatosis with a Separate Cyst

  • Kim, Seong-Ho (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Yoon, Soo-Han (Department of Neurosurgery, Ajou University School of Medicine) ;
  • Kim, Jang-Hee (Department of Pathology, Ajou University School of Medicine)
  • Published : 2009.09.28

Abstract

Meningioangiomatosis (MA) is a rare congenital tumor that occurs mostly in 5-15 year old children. There have been only 5 cases previously reported that described the cystic nature within these tumors. We present a case of a MA accompanied by a separate macrocyst. A normally developed 2 year-old female patient presented with partial and generalized seizures. The brain computerized tomogram and magnetic resonance imaging revealed the presence of a calcified mass accompanied by a cyst in the right parietal area, surrounded by low density and high attenuation edema and hemorrhage. Upon right parietal craniotomy, a $1.6cm{\times}1.2cm{\times}0.5cm$ sized plate-like, gray-white, slightly hard mass was seen and it was completely excised. Approximately 1 cm from the mass in the anterior lateral direction, a cyst was found and subsequent biopsy of the cyst wall revealed no tumor tissue, and therefore the cyst was not removed. Pathologic report demonstrated the meningioangiomatosis. Follow up examination 2 years later showed no recurrence of the tumor, and there was no evidence of neurological deficits. Authors suggest that cysts that arise in the surrounding tissues of tumors may not be tumor cysts, and do not require surgical removal.

Keywords

References

  1. Aizpuru RN, Quencer RM, Norenberg M, Altman N, Smirniotopoulos J : Meningioangiomatosis : clinical, radiologic, and histopathologic correlation. Radiology 179 : 819-821, 1991 https://doi.org/10.1148/radiology.179.3.2027998
  2. Blumenthal D, Berho M, Bloomfield S, Schochet SS Jr, Kaufman HH : Childhood meningioma associated with meningio-angiomatosis. Case report. J Neurosurg 78 : 287-289, 1993 https://doi.org/10.3171/jns.1993.78.2.0287
  3. Deb P, Gupta A, Sharma MC, Gaikwad S, Singh VP, Sarkar C : Meningioangiomatosis with meningioma : an uncommon association of a rare entity-report of a case and review of the literature. Childs Nerv Syst 22 : 78-83, 2006 https://doi.org/10.1007/s00381-004-1074-4
  4. Giangaspero F, Guiducci A, Lenz FA, Mastronardi L, Burger PC : Meningioma with meningioangiomatosis : a condition mimicking invasive meningiomas in children and young adults : report of two cases and review of the literature. Am J Surg Pathol 23 : 872-875, 1999 https://doi.org/10.1097/00000478-199908000-00002
  5. Halper J, Scheithauer BW, Okazaki H, Laws ER Jr : Meningioangiomatosis : a report of six cases with special reference to the occurrence of neurofibrillary tangles. J Neuropathol Exp Neurol 45 : 426-446, 1986 https://doi.org/10.1097/00005072-198607000-00005
  6. Harada K, Inagawa T, Nagasako R : A case of meningioangiomatosis without von Recklinghausen’s disease. Report of a case and review of 13 cases. Childs Nerv Syst 10 : 126-130, 1994 https://doi.org/10.1007/BF00302777
  7. Jallo GI, Kothbauer K, Mehta V, Abbott R, Epstein F : Meningioangiomatosis without neurofibromatosis : a clinical analysis. J Neurosurg 103 (4 Suppl) : 319-324, 2005
  8. Jay V, Edwards V, Varela-Stavrinou M, Rutka J : Unique intracerebral tumor with divergent differentiation in a patient presenting as NF2 : report of a case with features of astrocytoma, ependymoma, and PNET. Ultrastruct Pathol 21 : 57-71, 1997 https://doi.org/10.3109/01913129709023248
  9. Kim NR, Choe G, Shin SH, Wang KC, Cho BK, Choi KS, et al. : Childhood meningiomas associated with meningioangiomatosis : report of five cases and literature review. Neuropathol Appl Neurobiol 28 : 48-56, 2002 https://doi.org/10.1046/j.1365-2990.2002.00365.x
  10. Kim WY, Kim IO, Kim S, Cheon JE, Yeon M : Meningioangiomatosis: MR imaging and pathological correlation in two cases. Pediatr Radiol 32 : 96-98, 2002 https://doi.org/10.1007/s00247-001-0601-7
  11. Kobayashi H, Ishii N, Murata J, Saito H, Kubota KC, Nagashima K, et al. : Cystic meningioangiomatosis. Pediatr Neurosurg 42 : 320-324, 2006 https://doi.org/10.1159/000094071
  12. Kuchelmeister K, Richter HP, Kepes JJ, Schachenmayr W : Case report : microcystic meningioma in a 58-year-old man with multicystic meningioangiomatosis. Neuropathol Appl Neurobiol 29 : 170-174, 2003 https://doi.org/10.1046/j.1365-2990.2003.00458.x
  13. L$\acute{o}$pez JI, Ereno C, Oleaga L, Areitio E : Meningioangiomatosis and oligodendroglioma in a 15-year-old boy. Arch Pathol Lab Med 120 : 587-590, 1996
  14. Mut M, Söylemezoglu F, Firat MM, Palaoglu S : Intraparenchymal meningioma originating from underlying meningioangiomatosis. Case report and review of the literature. J Neurosurg 92 : 706-710, 2000 https://doi.org/10.3171/jns.2000.92.4.0706
  15. Oka Y, Sakaki S, Yamashita M, Nakagawa K, Matsuoka K, Matsui H : [ A case of meningioangiomatosis in an infant.] No Shinkei Geka 19 : 761-765, 1991
  16. Omeis I, Hillard VH, Braun A, Benzil DL, Murali R, Harter DH : Meningioangiomatosis associated with neurofibromatosis : report of 2 cases in a single family and review of the literature. Surg Neurol 65 : 595-603, 2006 https://doi.org/10.1016/j.surneu.2005.09.034
  17. Park MS, Suh DC, Choi WS, Lee SY, Kang GH : Multifocal meningioangiomatosis : a report of two cases. AJNR Am J Neuroradiol 20 : 677-680, 1999
  18. Seo DW, Park MS, Hong SB, Hong SC, Suh YL : Combined temporal and frontal epileptogenic foci in meningioangiomatosis. Eur Neurol 49 : 184-186, 2003 https://doi.org/10.1159/000069076
  19. Sinkre P, Perry A, Cai D, Raghavan R, Watson M, Wilson K, et al. : Deletion of the NF2 region in both meningioma and juxtaposed meningioangiomatosis : case report supporting a neoplastic relationship. Pediatr Dev Pathol 4 : 568-572, 2001 https://doi.org/10.1007/s10024001-0086-2
  20. Stemmer-Rachamimov AO, Horgan MA, Taratuto AL, Munoz DG, Smith TW, Frosch MP, et al. : Meningioangiomatosis is associated with neurofibromatosis 2 but not with somatic alterations of the NF2 gene. J Neuropathol Exp Neurol 56 : 485-489, 1997 https://doi.org/10.1097/00005072-199705000-00004
  21. Takeshima Y, Amatya VJ, Nakayori F, Nakano T, Sugiyama K, Inai K : Meningioangiomatosis occurring in a young male without neurofibromatosis : with special reference to its histogenesis and loss of heterozygosity in the NF2 gene region. Am J Surg Pathol 26 : 125-129, 2002 https://doi.org/10.1097/00000478-200201000-00017
  22. Tien RD, Osumi A, Oakes JW, Madden JF, Burger PC : Meningioangiomatosis : CT and MR findings. J Comput Assist Tomogr 16 : 361-365, 1992 https://doi.org/10.1097/00004728-199205000-00005
  23. Wang Y, Gao X, Yao ZW, Chen H, Zhu JJ, Wang SX, et al. : Histopathological study of five cases with sporadic meningioangiomatosis. Neuropathology 26 : 249-256, 2006 https://doi.org/10.1111/j.1440-1789.2006.00668.x
  24. Whiting DM, Awad IA, Miles J, Chou SS, Lüders H : Intractable complex partial seizures associated with occult temporal lobe encephalocele and meningioangiomatosis : a case report. Surg Neurol 34 : 318-322, 1990 https://doi.org/10.1016/0090-3019(90)90007-C
  25. Wiebe S, Munoz DG, Smith S, Lee DH : Meningioangiomatosis. A comprehensive analysis of clinical and laboratory features. Brain 122 : 709-726, 1999 https://doi.org/10.1093/brain/122.4.709
  26. Wixom C, Chadwick AE, Krous HF : Sudden, unexpected death associated with meningioangiomatosis : case report. Pediatr Dev Pathol 8 : 240-244, 2005 https://doi.org/10.1007/s10024-004-9105-4

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