Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Gray Matter Changes in Patients with Pathological Gambling : A Preliminary Study Using Voxel-Based Morphometry Study

병적 도박 환자에서의 회백질 부피 변화 분석 : 화소 기반 형태분석 방법을 이용한 예비 연구

  • Choi, Jung-Seok (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Shin, Young-Chul (Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University) ;
  • Jung, Wi Hoon (Interdisciplinary Program in Brain Science, Seoul National University) ;
  • Jung, Myung Hun (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Jang, Joon Hwan (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Kang, Do-Hyung (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Choi, Chi-Hoon (Department of Radiology, National Medical Center) ;
  • Kwon, Jun Soo (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Lee, Jun-Young (Department of Psychiatry, Seoul National University College of Medicine)
  • 최정석 (서울대학교 의과대학 정신과학교실) ;
  • 신영철 (성균관대학교 의과대학 강북삼성병원 정신과학교실) ;
  • 정위훈 (서울대학교 뇌과학 협동과정) ;
  • 정명훈 (서울대학교 의과대학 정신과학교실) ;
  • 장준환 (서울대학교 의과대학 정신과학교실) ;
  • 강도형 (서울대학교 의과대학 정신과학교실) ;
  • 최치훈 (국립의료원 영상의학과) ;
  • 권준수 (서울대학교 의과대학 정신과학교실) ;
  • 이준영 (서울대학교 의과대학 정신과학교실)
  • Published : 2009.08.31
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Abstract

Objectives : The purpose of this study was to examine structural abnormalities of brain in patients with pathological gambling(PG) using voxel-based morphometry. Methods : We compared gray matter(GM) volumes between 10 patients with PG and 14 age- and IQ-matched healthy controls and examined the relationship of GM volumes with clinical variables in patients with PG. Results : We found significant increase of GM volume in the superior, middle, and inferior frontal gyri, the midbrain, the middle temporal gyrus, the precuneus, and the fusiform gyrus of patients with PG. A significant decrease of GM volume was observed in the parahippocampal gyrus and the lingual gyrus of the patient group. In addition, GM volumes in some of these regions were positively associated with South Oaks Gambling Screen score and negatively with age of onset in patients with PG. Conclusion : Current findings indicate that structural abnormalities in the fronto-temporal cortex, the midbrain, and the precuneus might be involved in the pathophysiology of PG, and contribute to some of the behavioral changes observed in patients with PG.

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