Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

ORAL PEMPHIGUS VULGARIS: A CASE REPORT

구강내 발생한 심상성 천포창 환자의 치험례

  • Kim, Il-Kyu (Department of Oral and Maxillofacial Surgery, Department of Dentistry, College of Medicine, In-Ha University) ;
  • Choi, Jin-Ung (Department of Oral and Maxillofacial Surgery, Department of Dentistry, College of Medicine, In-Ha University) ;
  • Yang, Jung-Eun (Department of Oral and Maxillofacial Surgery, Department of Dentistry, College of Medicine, In-Ha University) ;
  • Jang, Jae-Won (Department of Oral and Maxillofacial Surgery, Department of Dentistry, College of Medicine, In-Ha University) ;
  • Sasikala, Balaraman (Department of Oral and Maxillofacial Surgery, Department of Dentistry, College of Medicine, In-Ha University) ;
  • Kim, Lucia (Department of Oral and Maxillofacial Surgery, Department of Pathology, College of Medicine, In-Ha University)
  • 김일규 (인하대학교 의과대학 치과학교실) ;
  • 최진풍 (인하대학교 의과대학 치과학교실) ;
  • 양정은 (인하대학교 의과대학 치과학교실) ;
  • 장재원 (인하대학교 의과대학 치과학교실) ;
  • 사시카라바라라만 (인하대학교 의과대학 치과학교실) ;
  • 김루시아 (인하대학교 의과대학 병리학교실)
  • Published : 2009.09.30
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Abstract

Pemphigus vulgaris is a chronic autoimmune intraepithelial blistering disease with oral mucosal manifestations that very often precede the skin lesions. The vesicles or bullae are produced by an acantholytic process, detachment of differentiating keratinocytes from one another in the epithelial stratum spino sum or spinous cell layer. The pathogenesis of this disease is initially manifested by IgG(mainly) binding to desmosome(desmoglein 3 or 1) in the intercellular spaces of epithelium. This autoantibody binding caused the release of a plasminogen activator(a proteolytic enzyme) from keratinocytes. This ultimately results in cell to cell separation. The mainstay therapy of pemphigus vulgaris is systemic corticosteroids and immunosuppressive agents to eliminate the pathogenic autoantibodies from circulation. A 41-year old woman presented with a 1.5 year history of oral ulceration. There were no lesions on the skin or other mucosal sites. Histology and immunostaining were consistent with pemphigus vulgaris. Control of oral ulceration and normal oral function were achieved after systemic corticosteroids and immunosuppressive agents were instituted.

Keywords

References

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