Genomics & Informatics

Korea Genome Organization (한국유전체학회)
권호 표지
DOI QR코드

DOI QR Code

The Korean Pharmacogenomic Database at NIFDS: 2008 Update

  • Kang, T.S. (Clinical Research Division, Toxicological Evaluation and Research Department, Korea Food and Drug Administration) ;
  • Woo, S.W. (Pharmaceutical Management Division, Korea Food and Drug Administration) ;
  • Park, H.J. (Clinical Research Division, Toxicological Evaluation and Research Department, Korea Food and Drug Administration) ;
  • Han, S.Y. (Clinical Research Division, Toxicological Evaluation and Research Department, Korea Food and Drug Administration) ;
  • Park, M.H. (Clinical Research Division, Toxicological Evaluation and Research Department, Korea Food and Drug Administration) ;
  • Chung, M.W. (Clinical Research Division, Toxicological Evaluation and Research Department, Korea Food and Drug Administration)
  • Published : 2009.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Since its first release in 2007, the National Institute of Food and Drug Safety Evaluation (NIFDS) has provided pharmacogenomic and comparative information specific to Koreans to allow regulatory reviewers and researchers to adapt their working practices to pharmacogenomics. The highlights of this year's additions include "Drug Information", "Gene Information" and "Pharmacogenomic information in the drug labels" sections. These new additions provide information on 737 genes, 719 drugs and pharmacogenomic data of the labels or relabels of 253 approved drugs as of November 2008. The latest version of the Korean Pharmacogenomic Database (KPD, release 2.0) has expanded significantly since its previous release. More SNP and haplotype information has been added to the database with the latest version of the KPD containing approximately four times as many SNPs and haplotypes than the previous version (719 vs. 152, and 30 vs. 7 respectively). Through the "SNP" and "Haplotype" sections, the KPD provides unique Korean SNP and haplotype information as well as comparative information of other populations (Japanese, Chinese, European, African) to offer a range of pharmacogenomic data that can help reviewers and the public understand pharmacogenomic information. The quality and quantity of information in the KPD has also been improved considerably. This data can be found at: http://www.nitr.go.kr/nitr/contents/m134700/view.do/.

Keywords

References

  1. Ardlie, K.G., Kruglyak, L., and Seielstad, M. (2002). Patterns of linkage disequilibrium in the human genome. Nat. Rev. Genet . 3, 299-309 https://doi.org/10.1038/nrg777
  2. Barrett, J.C., Fry, B., Maller, J., and Daly, M.J. (2005).Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265 https://doi.org/10.1093/bioinformatics/bth457
  3. Innocenti, F. (2005). The pharmacogenetics and pharmacogenomics knowledge base. HUMANA Press
  4. Karolchik, D., Kuhn, R.M., Baertsch, R., Barber, G.P., Clawson, H., Diekhans, M., Giardine, B., Harte, R.A., Hinrichs, A.S., Hsu, F., Kober, K.M., Miller, W., Pedersen, J.S., Pohl, A., Raney, B.J., Rhead, B., Rosenbloom, K.R., Smith, K.E., Stanke, M., Thakkapallayil, A., Trumbower, H., Wang, T., Zweig, A.S., Haussler, D., and Kent, W.J. (2008). The UCSC genome browser database: 2008 update. Nucl. Acids Res . 36, D773-779 https://doi.org/10.1093/nar/gkm966
  5. Kim, C.K., Jeon, Y.A., Cho, G.T., Kwon, S.W., Kim, Y.H.,and Hong, S.B. (2009). An intergrated database and web service for microbial resources at KACC. Genomics Inform. 7, 41-45 https://doi.org/10.5808/GI.2009.7.1.041
  6. Kuhn, R.M., Karolchik, D., Zweig, A.S., Trumbower, H., Thomas, D.J., Thakkapallayil, A., Sugnet, C.W., Stanke, M., Smith, K.E., Siepel, A., Rosenbloom, K.R., Rhead, B., Raney, B.J., Pohl, A., Pedersen, J.S., Hsu, F., Hinrichs, A.S., Harte, R.A., Diekhans, M., Clawson, H., Bejerano, G., Barber, G.P., Baertsch, R., Haussler, D., and Kent, W.J. (2007). The UCSC genome browser database: update 2007. Nucl. Acids Res . 35, D668-673 https://doi.org/10.1093/nar/gkl928
  7. Kuhn, R.M., Karolchik, D., Zweig, A.S., Wang, T., Smith, K.E., Rosenbloom, K.R., Rhead, B., Raney, B.J., Pohl, A., Pheasant, M., Meyer, L., Hsu, F., Hinrichs, A.S., Harte, R.A., Giardine, B., Fujita, P., Diekhans, M., Dreszer, T., Clawson, H., Barber, G.P., Haussler, D., and Kent, W.J. (2009). The UCSC genome browser database: update 2009. Nucl. Acids Res . 37, D755-761 https://doi.org/10.1093/nar/gkn875
  8. Tae Sun Kang, S.W.W., Hyun Joo Park, and Jaesook Roh. (2008). Korean pharmacogenomic database: pharmacogenomic haplotype analysis of the Korean population and ethnic comparisons. Biomol. Ther . 15, 77-81
  9. Tae, H., Han, J.M., Ahn, B.Y., and Park, K. (2009). Biostore: a repository system for registering and distributing public biology databases. Genomics Inform. 7, 49-51 https://doi.org/10.5808/GI.2009.7.1.049
  10. Thorisson, G.A., Smith, A.V., Krishnan, L., and Stein, L.D. (2005). The international HapMap project web site. Genome Res . 15, 1592-1593 https://doi.org/10.1101/gr.4413105
  11. Werner Kalow, U.A.M.a.R.F.T. (2002). WWW Bioinformatics Resources. Taylor & Francis
  12. Wheeler, D.L., Barrett, T., Benson, D.A., Bryant, S.H.,Canese, K., Chetvernin, V., Church, D.M., Dicuccio, M., Edgar, R., Federhen, S., Feolo, M., Geer, L.Y., Helmberg, W., Kapustin, Y., Khovayko, O., Landsman, D., Lipman, D.J., Madden, T.L., Maglott, D.R., Miller, V., Ostell, J., Pruitt, K.D., Schuler, G.D., Shumway, M., Sequeira, E., Sherry, S.T., Sirotkin, K., Souvorov, A., Starchenko, G., Tatusov, R.L., Tatusova, T.A., Wagner, L., and Yaschenko, E. (2008). Database resources of the national center for biotechnology information. Nucl. Acids Res . 36, D13-21椄돀ࠊ⨀塨?⨀ࢦ잖⨀䄄돐쁖잖⨀쁖잖⨀ウ잖⨀ᤄ덐䂦잖⨀᠄紀뢦잖⨀䂧잖⨀잖⨀梧잖⨀뢧잖⨀ࢨ잖⨀ https://doi.org/10.1093/nar/gkl1031

Cited by

  1. WebChemDB: An Integrated Chemical Database Retrieval System vol.7, pp.4, 2009, https://doi.org/10.5808/GI.2009.7.4.212