International Journal of Industrial Entomology and Biomaterials

Korean Society of Sericultural Science (한국잠사학회)
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The Effect of HPMC Concentration on the Morphology and Post Drawing of Wet Spun Regenerated SF/HPMC Blend Filaments

  • Ko, Jae-Sang (Department of Advanced Organic Materials Science and Engineering, Kyungpook National University) ;
  • Um, In-Chul (Department of Advanced Organic Materials Science and Engineering, Kyungpook National University)
  • Published : 2009.09.30
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Abstract

In this paper, the regenerated silk fibroin (SF)/hydroxypropyl methylcellulose (HPMC) blend filaments were prepared by wet spinning and the effect of HPMC concentration on the post drawing and morphology of blend filaments was elucidated. The result of maximum draw ratio indicated that the wet spinnability of wet spun SF / HPMC was improved with increasing HPMC concentration until 8% and remained constant after that concentration. The SEM observation revealed that the enhanced wet spinnability of blend filaments was strongly related to the morphological change by increasing HPMC concentration. Regardless of HPMC concentration, as SF content was reduced, the wet spinnability of blend film decreased resulting in reduced maximum draw ratio. It was also found by SEM observation that the cross section of blend filament deviated from circularity with an increase of HPMC content.

Keywords

References

  1. Gubbins RH, O Driscoll CM, Corrigan OI (2003) The effects of casein on diclofenac release from hydroxypropylmethylcellulose (HPMC) compacts. Int J Pharm 260, 69-76 https://doi.org/10.1016/S0378-5173(03)00235-7
  2. Ha SW, Tonelli AE, Hudson SM (2005) Structural studies of Bombyx mori silk fibroin during regeneration from solutions and wet fiber spinning. Biomacromolecules 6, 1722-1731 https://doi.org/10.1021/bm050010y
  3. Ki CS, Kim JW, Oh HJ, Lee KH, Park YH (2007) The effect of residual silk sericin on the structure and mechanical property of regenerated silk filament. Int J Biol Macromol 41, 346-353 https://doi.org/10.1016/j.ijbiomac.2007.05.005
  4. Ki CS, Park SY, Kim HJ, Jung HM, Woo KM, Lee JW, Park YH (2008) Development of 3-D nanofibrous fibroin scaffold with high porosity by electrospinning: implications for bone regeneration. Biotech lett 30, 405-410 https://doi.org/10.1007/s10529-007-9581-5
  5. Lee KH, Baek DH, Ki CS, Park YH (2007) Preparation and characterization of wet spun silk fibroin/poly(vinyl alcohol) blend filaments. Int J Biol Macromol 41, 168-172 https://doi.org/10.1016/j.ijbiomac.2007.01.011
  6. Lee KH, Ki CS, Baek DH, Kang GD, Ihm DW, Park YH (2005) Application of electrospun silk fibroin nanofibers as an immobilization support of enzyme. Fibers and Polymers 6, 181-185 https://doi.org/10.1007/BF02875641
  7. Maki KC, Davidson MH, Malik KC, Albrecht HH, O Mullane J, Daggy BP (1999) Cholesterol lowering with high-viscosity hydroxypropylmethylcellulose. Am J Cardiol 84, 1198-1203 https://doi.org/10.1016/S0002-9149(99)00534-2
  8. Marsano E, Corsini P, Arosio C, Boshi A, Mormino M, Freddi G (2005) Wet spinning of Bombyx mori silk fibroin dissolved in N-methyl morpholine N-oxide and properties of regenerated fibres. Int J Biol Macromol 37, 179-188 https://doi.org/10.1016/j.ijbiomac.2005.10.005
  9. Marsano E, Corsinia P, Canetti M, Freddi G (2008) Regenerated cellulose-silk fibroin blends fibers. Int J Biol Macromol 43, 106-114 https://doi.org/10.1016/j.ijbiomac.2008.03.009
  10. Meinel AJ, Kubow KE, Klotzsch E, Garcia-Fuentes M, Smith ML, Vogel V, Merkle HP, Meinel L (2009) Optimization strategies for electrospun silk fibroin tissue engineering scaffolds. Biomaterials 30, 3058-3067 https://doi.org/10.1016/j.biomaterials.2009.01.054
  11. Minoura N, Aiba S, Gotoh Y, Tsukada M, Imai Y (1995) Attachment and growth of cultured fibroblast cells on silk protein matrixes. J Biomed Mater Res 29, 1215-1221 https://doi.org/10.1002/jbm.820291008
  12. Sakabe H, Ito H, Miyamoto T, Noishiki, Ha WS (1989) In vivo blood compatibility of regenerated silk fibroin. Sen-i Gakkaishi 45, 487-490 https://doi.org/10.2115/fiber.45.11_487
  13. Trojani C, Weiss P, Michiels J, Vinatier C, Guicheux J, Daculsi G, Gaudray P, Carle GF, Rochet N (2005) Three-dimensional culture and differentiation of human osteogenic cells in an injectable hydroxypropylmethylcellulose hydrogel. Biomaterials 26, 5509-5517 https://doi.org/10.1016/j.biomaterials.2005.02.001
  14. Um IC (2002) Structural characteristics and properties of solution, blend film, and wet spun filament of regenerated silk fibroin prepared by formic acid, Ph. D. Thesis, Seoul National University, Republic of Korea
  15. Um IC, Kweon H, Lee KG, Ihm DW, Lee J, Park YH (2004a) Wet spinning of silk polymer: I. Effect of coagulation conditions on the morphological feature of filament. Int J Biol Macromol 34, 89-105 https://doi.org/10.1016/j.ijbiomac.2004.03.007
  16. Um IC, Ki CS, Kweon H, Lee GK, Ihm DW, Park YH (2004b) Wet spinning of silk polymer: II. Effect of drawing on the structural characteristics and properties of filament. Int J Biol Macromol 34, 107-119 https://doi.org/10.1016/j.ijbiomac.2004.03.011
  17. Yoshimizu H, Asakura T (1990) Preparation and characterization of silk fibroin powder and its application to enzyme immobilization. J Appl Polym Sci 40, 127-134 https://doi.org/10.1002/app.1990.070400111