Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지
DOI QR코드

DOI QR Code

Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

  • Kim, Yong-Soon (Department of Toxicopathology, Korea Environment & Merchandise Testing Institute) ;
  • Baek, Min-Won (Department of Toxicopathology, Korea Environment & Merchandise Testing Institute) ;
  • Sung, Jae-Hyuck (Department of Toxicopathology, Korea Environment & Merchandise Testing Institute) ;
  • Ryu, Hyun-Youl (Department of Toxicopathology, Korea Environment & Merchandise Testing Institute) ;
  • Kim, Jin-Sik (Department of Toxicopathology, Korea Environment & Merchandise Testing Institute) ;
  • Cho, Hyun-Sun (Department of Toxicopathology, Korea Environment & Merchandise Testing Institute) ;
  • Choi, Byung-Gil (Department of Toxicopathology, Korea Environment & Merchandise Testing Institute) ;
  • Song, Min-Sub (Department of Toxicopathology, Korea Environment & Merchandise Testing Institute) ;
  • Song, Moon-Yong (Department of Toxicopathology, Korea Environment & Merchandise Testing Institute) ;
  • Baik, Eun-Ju (Department of Toxicopathology, Korea Environment & Merchandise Testing Institute) ;
  • Choi, Young-Kuk (Department of Toxicopathology, Korea Environment & Merchandise Testing Institute) ;
  • Kim, Jong-Kyu (Korea Occupational Safety and Health Agency) ;
  • Yu, Il-Je (Fusion Technology Research Institute, Hoseo University) ;
  • Song, Kyung-Seuk (Department of Toxicopathology, Korea Environment & Merchandise Testing Institute)
  • Published : 2009.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 mg/kg body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 mg/kg body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 mg/kg body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

Keywords

References

  1. Budavari, S. (1989). The Merck index: An encyclopedia of chemicals, drugs, and biological. (11th edition), Merck & Co Rahway, New Jersey, pp. 87, 7636, 8604
  2. Food and Drug Administration (FDA, 1998). Frequency of use of cosmetic ingredients. FDA database. Washington D.C., USA
  3. Gamboa, P.M., C.G. de la Cuesta, B.E. Garcia, J.G. Castillo, and A. Oehling. (1999). Late asthmatic reaction in a hairdresser, due to the inhalation of ammonium persulfate salts. Allegol. Immunopathol., 17, 109-111
  4. Huntington Research Center (1997). Ames metabolic activation test to assess the potential mutagenic effect of Ammonium Persulfate. WLA5/77483. (July 14). Unpublished data submitted by CTFA, Washington D.C., USA
  5. Korean Ministry of Labor (2008). Korean Ministry of Labor Additives codex (Notification No. 2008-11). Examination of toxic risk about industrial chemicals. Ministry of Labor, Korea, pp. 58-110
  6. Last, J.A., Dasgupta, P.K., DeCesare, K. and Tarkington, B.K. (1982). Inhalation toxicology of ammonium persulfate an oxidant aerosol in rats. Toxicology and Applied Pharmacology, 63, 257-263 https://doi.org/10.1016/0041-008X(82)90047-3
  7. Matsuzawa, T. and Inoue, H. (2000). Biological Reference Data on CD(SD)IGS Rats, CD (SD) IGS Study Group in Charles River Japan, Yokohama, Japan
  8. Mensing, T., Marek, W., Raulf, H.M. and Baur, X. (1998). Acute exposure to hair bleach causes airway hyperresponsiveness in a rabbit model. European Respiratory Journal, 12, 1371-1374 https://doi.org/10.1183/09031936.98.12061371
  9. Merget, R., Buenemann, A., Kulzer, R., Rueckmann, A., Breitstadt, R., Kniffka, A., Kratisch, H., Vormberg, R. and Schultze-Werninghaus, G. (1999). A cross sectional study of chemical industry workers with occupational exposure to persulfates. Occup. Environ. Med., 53, 422-426 https://doi.org/10.1136/oem.53.6.422
  10. Nikitakis, J.M. and McEwen, G.N. Jr. (1990). CTFA compendium of cosmetic ingredient composition: Specifications. Unpublished data submitted by CTFA, Washington D.C., USA
  11. Organization for Economic Cooperation and Development (OECD 1998). Guidelines for the Testing of Chemicals (Sep 21, 1998) TG No. 408 Repeated Dose 90-day Oral Toxicity Study in Rodent. OECD Paris
  12. Organization for Economic Cooperation and Development (OECD 2001). Guidelines for the Testing of Chemicals (Dec 17, 2001) TG No. 423 Acute Toxic Class Method. OECD Paris
  13. Registry of Toxic Effects of Chemical Substances (RTECS, 1994). Ammonium and Potassium Persulfate entries. RTECS database. Bethesda, USA
  14. Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A. and Nycum, J.S. (1969). Range-finding toxicity data: List. Am. Ind. Hyg. Assoc. J., 30, 470-476 https://doi.org/10.1080/0002889698506077
  15. The Cosmetic, Toiletry, and Fragrance Association (CTFA, 1994). Summary of data on Ammonium persulfate. Unpublished data submitted by CTFA, Washington D.C., USA
  16. United Nation Environment Programme (UNEP, 2005) Chemical Screening Information Datasheet (SIDS) for High Volume Chemical, UNEP office, New York, USA
  17. Vanjoost, T.H. and Roesyanto, I.D. (1991). Sensitization to persulphates in occupational and non-occupational hand dermatitis. Contact Dermatitis, 24, 376-378
  18. Wenninger, J.A., Canterbery, R.C. and McEwen, G.N. Jr. (2000). International cosmetic ingredient dictionary handbook, (8th edition), CTFA, Washington D.C., USA, 1-2, pp. 80, 1168, 1387

Cited by

  1. Exploring the Critical Factors Limiting Polyaniline Biocompatibility vol.11, pp.2, 2019, https://doi.org/10.3390/polym11020362