The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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A Retrospective Study on the Influence of Kamisoyo-san (Jiaweixiaoyao-san) on Improving Ovarian Function in Child-bearing Period Infertile Women with Ovarian Dysfunction

가미소요산(加味逍遙散)이 가임기 난소기능저하 불임여성의 난소기능개선에 미치는 영향에 관한 후향적 연구

  • Lee, Han-Sung (Department of Pathology, College of Oriental Medicine, Kyung Hee University) ;
  • Cho, Kwang-Ho (With-Nature Oriental Clinic Group) ;
  • Kim, Tae-Kyung (With-Nature Oriental Clinic Group) ;
  • Kim, Choon-Hwan (With-Nature Oriental Clinic Group) ;
  • Ahn, Soo-Jung (With-Nature Oriental Clinic Group) ;
  • Ahn, Kwang-Seok (Department of Pathology, College of Oriental Medicine, Kyung Hee University) ;
  • Shim, Bum-Sang (Department of Pathology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Sung-Hoon (Department of Pathology, College of Oriental Medicine, Kyung Hee University) ;
  • Choi, Seung-Hoon (Department of Pathology, College of Oriental Medicine, Kyung Hee University) ;
  • Jung, Yun-Jae (Department of Microbiology, Graduate School of Medicine, Gachon University of Medicine and Science) ;
  • Ahn, Kyoo-Seok (Department of Pathology, College of Oriental Medicine, Kyung Hee University)
  • 이한성 (경희대학교 한의과대학 병리학교실) ;
  • 조광호 (자연담은 한의원 그룹) ;
  • 김태경 (자연담은 한의원 그룹) ;
  • 김춘환 (자연담은 한의원 그룹) ;
  • 안수정 (자연담은 한의원 그룹) ;
  • 안광석 (경희대학교 한의과대학 병리학교실) ;
  • 심범상 (경희대학교 한의과대학 병리학교실) ;
  • 김성훈 (경희대학교 한의과대학 병리학교실) ;
  • 최승훈 (경희대학교 한의과대학 병리학교실) ;
  • 정윤재 (가천의과학대학교 의학전문대학원 미생물학교실) ;
  • 안규석 (경희대학교 한의과대학 병리학교실)
  • Published : 2009.09.30
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Abstract

Objectives: This study was performed to elicit the effectiveness of a herbal formula, Kamisoyo-san (Jiaweixiaoyaosan) on enhancing ovarian function in infertile woman with ovarian dysfunction. Methods: 28 patients who initially visited between November 2006 and February 2009 and were administered Kamisoyo-san until May 2009 were retrospectively evaluated for their ovarian function by means of basal FSH (b-FSH), menstrual cycle, body mass index (BMI), and body fat ratio. To identify the major factor of improving ovarian function, 28 patients were classified into two groups by criteria of patent factors, such as pre-administration b-FSH, patient age, and treatment duration, respectively. Two groups were compared in terms of pregnancy percentage, b-FSH, menstrual cycle, BMI, and body fat ratio. Results: Post-administration b-FSH significantly decreased in comparison with pre-administration (p=0.004). The higher group (b-FSH $\geq$ 25mIU/mL) in pre-administration b-FSH was more effective in decrease of post-administration b-FSH than the lower one (10mIU/mL < b-FSH < 25mIU/mL). Conclusion: Kamisoyo-san may have a therapeutic effect on the infertility of child bearing period woman with ovarian dysfunction.

Keywords

References

  1. Jonathan SB, Eli YA, Paula AH. Novak’s Gynecology, 12th Ed. Baltimore:Williams & Wilkins. 1996:916-7.
  2. Lee JY. Reproductive Endocrinology. Seoul:Seoul National University Press. 2002:13-4.
  3. Jee BC. The usefulness of evaluation method in ovarian function. J Korean Obstetrics and Gynecol. 2008:65-6.
  4. Sin GS, Sin YW, Jeong JH, Lee BR. Clinical case study on the effect of Danchisoyo-san utilizing for menopause. The Journal of Oriental Obstetrics and Gynecology. 2003;16(4):77-82.
  5. Kim DI, Woo DY, Seo JW, Lee TK. The management of climacteric syndrome clinic and the herbal medicine for that clinic. The Journal of Oriental Gynecology. 2000;13(2):418-36.
  6. Korea National Statistical Office. The social index of Republic of Korea in 2008. Seoul:Korea National Statistical Office. 2008:94.
  7. te Velde ER, Scheffer GJ, Dorland M, Broekmans FJ, Fauser BC. Developmental and endocrine aspects of normal ovarian aging. Mol Cell Endocrinol 1998;145:67-73. https://doi.org/10.1016/S0303-7207(98)00171-3
  8. Dei M, Seravalli V, Bruni V, Balzi D. Pasqua A. Predictors of recovery of ovarian function after weight gain in subjects with amenorrhea related to restrictive eating disorders. Gynecol Endocrinol. 2008;24(8):459-64. https://doi.org/10.1080/09513590802246141
  9. Takeuchi T, Tsutsumi O, Iketzuki Y, Takai Y, Taketani Y. Positive Relationship between Androgen and the Endocrine Disruptor, Bisphenol A, in Normal Women and Women with Ovarian Dysfunction. Endocrinol J. 2004;51(2):165-9.
  10. Chen SW. The formula book edited by greatly peaceful benefiting the people office (TaiPing-HuiMinHeJiJuFang). Beijing:People’s medical publishing house. 1985:308.
  11. Xue J. Summary on Essentials in Internal Medicine (NeiKeZhaiYao). Beijing:People’s medical publishing house. 1983:60.
  12. Park CS, Sohn YJ. A Study on the Effects of Gamisoyo-san on Ovariectomized Osteoporosis in Rats. The Journal of Oriental Obstetrics and Gynecology. 2008;27(1):1-15.
  13. Kim SH, Cho JH, Jang JB, Lee KS. A case report of managing the premature ovarian failure patient. The Journal of Oriental Obstetrics and Gynecology. 2003;16(3):194-9.
  14. David HB, Andrea W, Norbert G. Comparing anti-Mullerian hormone (AMH) and folliclestimulating hormone (FSH) as predictors of ovarian function. Fertil Steril. 2008;91(4):1553-5. https://doi.org/10.1016/j.fertnstert.2008.09.069
  15. Grynberg M, Feyereisen E, Scheffer JB, Koutroubis P, Frydman R, Fanchin R. Early follicle development alters the relationship between antral follicle counts and inhibin B and folliclestimulating hormone levels on cycle day 3. Fertil Steril. 2008; in press.
  16. Korean Society for the Study of Obesity. Clinical Obesity, 2nd Ed. Seoul:Korea Medical Book Publisher. 2001:215-9.
  17. Robker RL, Akison LB, Bennett BD, Thrupp PN, Chura LR, Russell DL, et al. Obese women exhibit differences in ovarian metabolites, hormones, and gene expression compared with moderateweight women. J Clin Endocrinol Metab. 2009. May;94(5):1533-40. https://doi.org/10.1210/jc.2008-2648
  18. Rose E. Body fat, puberty, and fertility. Biological Reviews. 2008;59(2):161-8. https://doi.org/10.1111/j.1469-185X.1984.tb00406.x
  19. Choi EM, Heo JW, Kim SR, Kang MJ. A clinical study on infertility with premature ovarian failure. The Journal of Oriental Gynecology. 2001;14(1):393-408.