The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Inhibitory Effect of Extract of Trogopterorum Faeces on the Production of Inflammatory Mediaters

오령지 추출물의 염증성 세포활성물질 억제효과

  • Kim, Byung-Jin (Dept. of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Ham, Kyung-Wan (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Park, Kyung-Bae (Dept. of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Kim, Dae-Hyeon (Dept. of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Jo, Beom-Yeon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Cho, Chang-Re (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Cho, Gil-Hwan (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Bae, Gi-Sang (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Park, Kyoung-Chel (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Koo, Bon-Soon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Min-Sun (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Song, Ho-Joon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Park, Sung-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
  • 김병진 (원광대학교 약학대학 한약학과) ;
  • 함경완 (원광대학교 한의과대학 본초학교실) ;
  • 박경배 (원광대학교 약학대학 한약학과) ;
  • 김대현 (원광대학교 약학대학 한약학과) ;
  • 조범연 (원광대학교 한의과대학 본초학교실) ;
  • 조창래 (원광대학교 한의과대학 본초학교실) ;
  • 조길환 (원광대학교 한의과대학 본초학교실) ;
  • 배기상 (원광대학교 한의과대학 본초학교실) ;
  • 박경철 (원광대학교 한의과대학 본초학교실) ;
  • 구본순 (원광대학교 한의과대학 본초학교실) ;
  • 김민선 (원광대학교 한의과대학 본초학교실) ;
  • 송호준 (원광대학교 한의과대학 본초학교실) ;
  • 박성주 (원광대학교 한의과대학 본초학교실)
  • Published : 2009.09.30
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Abstract

Objectives : The purpose of this study was to investigate the anti-inflammatory effects of extract from Trogopterorum Faeces (TF) on the RAW 264.7 cells. Methods : To prove the TF's anti-inflammatory effects, we investigated nitric oxide (NO) production and own cell viability. We examined the cytokine productions on lipopolysacchride (LPS)-induced RAW 264.7 cells and also cellular regulatory mechanisms. Results : TF does not have any cytotoxic effect. TF reduced LPS-induced NO production, interleukin (IL)-1b, IL-6, IL-10 and tumor necrosis factor-a (TNF-a) in RAW 264.7 cells. TF inhibited the activation of mitogen-activated protein kinases (MAPKs) such as p38, extracelluar signal-regulated kinase (ERK 1/2) and c-Jun NH2-terminal kinase (JNK) and also the degradation of inhibitory kappa B a (Ik-Ba) in the LPS-stimulated RAW 264.7 cells. TF reduced the serum levels of IL-1b, IL-6, TNF-a. The survival rate of LPS-induced endotoxin shock was increased by TF administration. Conclusions : TF down-regulated LPS-induced NO and cytokines production, which could provide a clinical basis for anti-inflammatory properties.

Keywords

References

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