Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Association of Diabetes Mellitus and Metabolic Syndrome with Idiopathic Pulmonary Fibrosis

폐섬유화증과 당뇨와 대사 증후군의 연관성 연구

  • Kim, Yu Jin (Division of Pulmonology, Department of Internal Medicine, Gachon University Gil Hospital) ;
  • Park, Jeong-Woong (Division of Pulmonology, Department of Internal Medicine, Gachon University Gil Hospital) ;
  • Kyung, Sun Young (Division of Pulmonology, Department of Internal Medicine, Gachon University Gil Hospital) ;
  • An, Chang Hyeok (Division of Pulmonology, Department of Internal Medicine, Gachon University Gil Hospital) ;
  • Lee, Sang Pyo (Division of Pulmonology, Department of Internal Medicine, Gachon University Gil Hospital) ;
  • Park, Hye Yun (Division of Pulmonology, Department of Internal Medicine, Sungkyunkwan University Samsung Medical Center, College of Medicine) ;
  • Chung, Man Pyo (Division of Pulmonology, Department of Internal Medicine, Sungkyunkwan University Samsung Medical Center, College of Medicine) ;
  • Jeong, Sung Hwan (Division of Pulmonology, Department of Internal Medicine, Gachon University Gil Hospital)
  • 김유진 (가천의대길병원 호흡기내과) ;
  • 박정웅 (가천의대길병원 호흡기내과) ;
  • 경선영 (가천의대길병원 호흡기내과) ;
  • 안창혁 (가천의대길병원 호흡기내과) ;
  • 이상표 (가천의대길병원 호흡기내과) ;
  • 박혜윤 (성균관대학교 의과대학 내과학교실 삼성서울병원 호흡기내과) ;
  • 정만표 (성균관대학교 의과대학 내과학교실 삼성서울병원 호흡기내과) ;
  • 정성환 (가천의대길병원 호흡기내과)
  • Received : 2009.05.29
  • Accepted : 2009.07.13
  • Published : 2009.08.30
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Abstract

Background: Reactive oxygen species (ROS) by oxidative stress may play an important role in the pathogenesis of various chronic diseases such as diabetes mellitus, obesity, hyperlipidemia, hypertension and malignancy that are linked to metabolic syndrome. Oxidative stress has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). We examined the relationship between IPF and presenting factors associated with metabolic disorders. Methods: One hundred fourteen patients who met the current consensus of IPF definition were enrolled from March 2000 to April 2006 in Gil Hospital and Samsung Medical Center in Korea. One hundred thirty-four control subjects without pulmonary diseases were selected from subjects who visited Gil hospital for routine medical examinations, including low-dose chest computed tomography from January 2002 to July 2006. Retrospectively, we analyzed the clinical characteristics, the results of blood examinations, and lung function tests from medical records of both groups. Results: IPF patients and control subjects differed in the prevalence of diabetes mellitus as assessed by univariate analysis. Multivariate analysis demonstrated that diabetes mellitus and obesity were associated with IPF. The adjusted odds ratios for diabetes mellitus were 2.733 (95% confidence interval [CI], 1.282~5.827) and 2.001 (95% [CI], 1.063~3.766) for obesity. The remaining factors tested showed no differences between the patient group and the control. Conclusion: Diabetes mellitus and obesity may be associated with IPF development.

Keywords

References

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