Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Inhibitory Effects of Water Extract of Lindera obtusiloba on the Mast Cell-Mediated Allergic Inflammation

생강나무 추출물의 알레르기성 염증반응 억제 효과

  • Kim, Sang-Hyun (Department of Pharmacology, School of Medicine, Kyungpook National University) ;
  • Son, Jun-Ho (Daegu.Gyeongbuk Institute for Oriental medicine Industry) ;
  • Lee, Seung-Ho (College of Pharmacy, Yeungnam University)
  • Published : 2009.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Lindera obtusiloba has been used for centuries as a traditional medicine in Korea and recently known to have an anti-fibrotic effect. In this report, we investigated the effect of hot water extract from L. obtusiloba (WELB) on the mast cell-mediated allergic inflammation and studied its possible mechanisms of action. WELB inhibited phorbol-12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced histamine release in HMC-1 human mast cells. WELB reduced PMACI-induced gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-$\alpha$, interleukin (IL)-$1{\beta}$, IL-6, and IL-8. The inhibitory effect of WELB on the expression of proinflammatory cytokines was c-jun N-terminal kinase and nuclear factor-${\kappa}B$ dependent. These results indicate that WELB may be beneficial in the treatment of mast cell-mediated allergic inflammation.

Keywords

References

  1. Metcalfe, D. D., Kaliner, M. and Donlon, M. A. (1981) The mast cell. Crit. Rev. Immunol. 3: 23
  2. Miyajima, I., Dombrowicz, D., Martin, T. R., Ravetch, J. V., Kinet, J. P. and Galli, S. J. (1997) Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. J. Clin. Invest. 99: 901 https://doi.org/10.1172/JCI119255
  3. Church, M. K. and Levi-Schaffer, F. (1997) The human mast cell. J. Allergy Clin. Immunol. 99: 155 https://doi.org/10.1016/S0091-6749(97)70089-7
  4. Petersen, L. J., Mosbech, H. and Skov, P. S. (1996) Allergeninduced histamine release in intact human skin in vivo assessed by skin microdialysis technique: characterization of factors influencing histamine releasability. J. Allergy Clin. Immunol. 97: 672 https://doi.org/10.1016/S0091-6749(96)70313-5
  5. Ennis, M., Pearce, F. L. and Weston, P. M. (1980) Some studies on the release of histamine from mast cells stimulated with polylysine. Br. J. Pharmacol. 70: 329 https://doi.org/10.1111/j.1476-5381.1980.tb07940.x
  6. Alfonso, A., Cabado, A. G., Vieytes, M. R. and Botana, L. M. (2000) Functional compartments in rat mast cells for cAMP and calcium on histamine release. Cell Signal. 12: 343 https://doi.org/10.1016/S0898-6568(00)00070-X
  7. Beaven, M. A., Rogers, J., Moore, J. P., Hesketh, T. R., Smith, G. A. and Metcalfe, J. C. (1984) The mechanism of the calcium signal and correlation with histamine release in 2H3 cells. J. Biol. Chem. 259: 7129
  8. Botana, L. M. and MacGlashan, D. W. (1994) Differential effects of cAMP-elevating drugs on stimulus-induced cytosolic calcium changes in human basophils. J. Leukoc. Biol. 55: 798 https://doi.org/10.1002/jlb.55.6.798
  9. Galli, S. J., Gordon, J. R. and Wershil, B. K. (1991) Cytokine production by mast cells and basophils. Curr. Opin. Immunol. 3: 865 https://doi.org/10.1016/S0952-7915(05)80005-6
  10. Galli, S. J., Kalesnikoff, J., Grimbaldeston, M. A., Piliponsky, A. M., Williams, C. M. and Tsai, M. (2005) Mast cells as 'tunable' effector and immunoregulatory cells: recent advances. Annu. Rev. Immunol. 23: 749 https://doi.org/10.1146/annurev.immunol.21.120601.141025
  11. Azzolina, A., Bongiovanni, A. and Lampiasi, N. (2003) Substance P induces TNF-alpha and IL-6 production through NF kappa B in peritoneal mast cells. Biochim. Biophys. Acta. 1643: 75 https://doi.org/10.1016/j.bbamcr.2003.09.003
  12. Kim, S. H., Jun, C. D., Suk, K., Choi, B. J., Lim, H., Park, S., Lee, S. H., Shin, H. Y., Kim, D. K. and Shin, T. Y. (2006) Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells. Toxicol. Sci. 91: 123 https://doi.org/10.1093/toxsci/kfj063
  13. 중약대사전 상해과학기술출판사 1913