YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Function of Reactive Oxyegn Species in Bone Loss

골손실을 조절하는 활성산소종의 역할 규명

  • Yang, Mi-Hye (College of Natural Sciences, Kyungpook National University) ;
  • Park, Hyo-Jung (College of Pharmacy, Sookmyung Women's University) ;
  • Lee, Dong-Seok (College of Natural Sciences, Kyungpook National University) ;
  • Yim, Mi-Jung (College of Pharmacy, Sookmyung Women's University)
  • 양미혜 (경북대학교 자연과학대학 생명공학부) ;
  • 박효정 (숙명여자대학교 약학대학) ;
  • 이동석 (경북대학교 자연과학대학 생명공학부) ;
  • 임미정 (숙명여자대학교 약학대학)
  • Published : 2009.08.31
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Abstract

We explored the role of reactive oxygen species (ROS) in LPS-induced bone loss. LPS was shown to increase the concentration of ROS in osteoclast precursors. The antioxidant decreased osteoclast formation by LPS. Furthermore, the antioxidant decreased NFATc1 expression by LPS, suggesting that ROS mediates NFATc1 expression in the regulation of LPS-induced osteoclast formation. Finally, the antioxidant decreased LPS-induced RANKL mRNA expression in osteoblasts. Taken together, these data indicate that LPS mediates ROS to induce bone loss.

Keywords

References

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