The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Hypoglycemic Effect of Angelica gigas Naki Extract in Streptozotocin-induced Diabetic Rats

Streptozotocin 유도 흰쥐에서 참당귀(Angelica gigas Naki) 추출물의 당뇨 개선 효과

  • Park, Man-Jong (Food Safely Management Division, Daejeon Regional Food & Drug Administration) ;
  • Kang, Shin-Jyung (Dept. of Medicines Resources, Graduate School of Joongbu University) ;
  • Kim, Ae-Jung (Dept. of Food & Nutrition, Hyejeon College)
  • 박만중 (대전식품의약품안전청 식품안전관리과) ;
  • 강신정 (중부대학교 한약자원학과) ;
  • 김애정 (혜전대학 식품영양과)
  • Published : 2009.06.30
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Abstract

This study examined the possible hypoglycemic effects Angelica gigas Naki extracts in streptozotocin-induced diabetic rats(STZ+50%, STZ+100% EtOH and STZ+water). The studies showed that administration of the Angelica gigas Naki extract decreased high blood glucose levels(more than 300 mg/$d{\ell}$) to a normal level(104 mg/$d{\ell}$) in the STZ+50% EtOH group. Liver glucokinase levels were significantly increased in STZ+50% EtOH and STZ+100% EtOH groups compared to the STZ group. Moreover, the liver acetyl CoA carboxylase level was significantly increased in STZ+50% EtOH, STZ+100% EtOH and STZ+water groups compared to the STZ group. These results suggest that the Angelica gigas Naki extract in the STZ+50% EtOH group exerted an ameliorable effect and can be used as an anti-diabetic substance, either as a dietary supplements or as a new drug.

Keywords

References

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