Hypoglycemic Effect of Eriobotrya japonica(E. japonica) in db/db Mice

db/db 마우스에서 비파의 혈당 저하 효과

  • Published : 2009.06.30

Abstract

E. japonica is a well-known medicinal plant in Japan. The leaves of E. japonica were reported to have a hypoglycemic action. However, seeds of E. japonica are discarded and not used. To elucidate for anti-diabetic effects of E. japonica, Type 2 diabetic mice were allocated to control group, E. japonica leaf, and seed extract group. Animals were fed a 2018S Teklad global 18% protein rodent diet. Animals were received daily oral injections of E. japonica leaf or seed extract at a dose of 200 mg/kg body weight for 6 weeks. Body weight, food intake and water intake, and total adipose tissue weight of animals were significantly reduced by feeding of E. japonica leaf extract. All E. japonica extract groups significantly decreased fasting blood glucose, glycosylated hemoglobin levels, size of adipocytes and serum adiponectins. However, they did not have a beneficial effect on the serum triglyceride and cholesterol in the diabetic animals. These results suggest that E. japonica seed and leaf extracts have a antidiabetic effect by controlling of blood glucose and decrease of size of adipocytes in db/db mice and seed extract is more effective in hypoglycemic action than leaf extract.

Keywords

References

  1. Groop LC. 1992. Slfonyl ureas in NIDDM. Diabetes Care 15:737-754 https://doi.org/10.2337/diacare.15.6.737
  2. Guerre-Millo M, Gervois P, Raspe E, Madsen L, Poulain P, Derudas B, Hervert JM, Sinegar DA, Sillsin TM, Fruchart JC, Berge RK, Staels B. 2002. Peroxisome proliferatoractivated receptor activators improve insulin sensitivity and reduce adiposity. J Biol Chem 275:16638-16642 https://doi.org/10.1074/jbc.275.22.16638
  3. Gwak JH, Lee JH, Lee SJ, Park HW, Kim Y, Hyun YJ. 2007. The effect of L-carnitine and isoflavone supplementation on weight reduction and visceral fat accumulation in overweigh women. Kor J Nutr 40:630-638
  4. Jung HA, Park JC, Chung HY, Kim J, Choi JS. 1994. Antioxidant flavonoids and chlorogenic acid from the leaves of Eriobotrya japonica. Arch Pharm Res 22:213-218 https://doi.org/10.1007/BF02976549
  5. Jung UJ, Lee MK, Park YB, Jeon SM, Choi MS. 2006. Antihyperglycemic and antioxidant properties of caffeic acid in db/db mice. J Pharmacol & Experimental Therapeutics 318:476-483 https://doi.org/10.1124/jpet.106.105163
  6. Kang TH, Choi S, Lee T, Son M, Park J, Kim SY. 2008. Characteristics of antidiabetic effect of Dioscorea rhizoma(1)-Hypoglycemic effect-. Kor J Food & Nutr 21:425-429
  7. Kim OK. 1992. The screening of plants for hypoglycemic action in normal and alloxan-induced hyperglycemic rats. Kor J Pharmacogn 23:117-119
  8. Kim YY, Choue RW, Chung SH, Koo SJ. 1999. Anti- hyperglycemic effect of Cortex Mori radicis in db/db mice. Kor J Food Sci Technol 31:1057-1064
  9. Kim SH, Hyun SH, Choung SY. 2006. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J. Ethnopharmacol 104:119-123 https://doi.org/10.1016/j.jep.2005.08.059
  10. Kim SG, Choi DS. 2008. The present state of diabetes mellitus in Korea. J Korean Med Assoc 51:791-798 https://doi.org/10.5124/jkma.2008.51.9.791
  11. Koivisto VA. 1993. Insulin therapy in typeII diabetes. Diabetes Care 16(suppl 3):29-39
  12. Leahy JL. 2005. Pathogenesis of type 2 diabetes mellitus. Archives Med Res 36:197-209 https://doi.org/10.1016/j.arcmed.2005.01.003
  13. Lee CB. 1982. Korean Pictorial Book of Plants. pp.684-687. Hyangmoonsa
  14. Lee JC. 1995. Todays Theraphy for Diabetes, Shinil Co
  15. Lee HJ, Choi SS, Park MK, An YJ, S SY, Kim MC, Hong SH, Hwang TH, Kang DY, Garber AJ, Kim DK. 2002. Fenofibrate losers abdominal and skeletal adiposity and improves insulin sensitivity in OLETF rats. Biochem Biophys Res Commun 296:293-299 https://doi.org/10.1016/S0006-291X(02)00822-7
  16. Lee YR, Nam SH, Kang, MY. 2006. Hypoglycemic effect of the giant embryoric rice supplementation on sterptozotocin induced diabetic rats. Korean J Food Sci Technol 38:427-431
  17. Lee HJ, Park MK, Lee KI, An YJ, Kim JM, Park JY, Han Y, Hong SH, Choi SS, Yoo YH, Suh JD, Kim DK. 2007. Prevention of diabetes by fenofibrate in OLETE rats: Hepatic mechanism for reducing visceral adiposity. J Kor Diabetes Assoc 31:63-74 https://doi.org/10.4093/jkda.2007.31.1.63
  18. Medvedva IV, Pufacheval TA, Dorodneva EF. 2002. Influence of glucose control on the main parameters of serum lipid profile and platelet membranes in patients with metabolic syndrome and type 2 diabetes mellitus. Atherosclerosis supplements 3:163 https://doi.org/10.1016/S1567-5688(02)80452-4
  19. Nazato N, Matsumoto K, Uemitsu N. 1994. Triterpenes from leaves of Eriobotrya japonica Nat Med 48:336
  20. Shimizu M, Uemitsu N, Shirota M, Matsumato K, Tezuka Y. 1996 A new triterpene ester from Eriobotrya japonica. Chem Pham Bull 44:2191-2182
  21. Shin J, Han MJ, Lee YC, Moon YI, Kim DH. 2002. Antidiabetic activity of Opuntia ficus-Indica var. sabatan on db/db mice. Kor J Pharmacogn 33:332-336
  22. Tomoyuki H, Nobuya S, Masataka S, Hiramitsu S, Yasuo K. 2008. Levels of plasma insulin, leptin and adiponectin, and activities of key enzymes in carbohydrate metabolism in skeletal muscle and liver in fasted ICR mice fed dietary n-3 polyunsaturated fatty acids. J Nutr Biochem 19:577-586 https://doi.org/10.1016/j.jnutbio.2007.08.001
  23. Yuan HD, Shin EJ, Chung SH. 2008. Anti-diabetic effect and mechanism of Korean red ginseng in C57BL/KsJ db/db mice. J Ginseng Res 32:187-193 https://doi.org/10.5142/JGR.2008.32.3.187
  24. Zimmet P, Alberti K, Shaw J. 2001. Global and societal implications of the diabetes epidemic. Nature 14:788-791 https://doi.org/10.1038/414782a