대한한의학회지 (The Journal of Korean Medicine)

  • 제30권4호
  • /
  • Pages.129-141
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  • 2009
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  • 1010-0695(pISSN)
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  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

선학초 (짚신나물) 복강주사의 항암효과 탐색 및 약물 대사효소의 변화

The Anticancer Effects and Drug Metabolic Enzyme Change by Intraperitoneal Injection of Agrimonia Pilosa Ledeb

  • 최정원 (경원대학교 한의과대학 내과학교실) ;
  • 장보형 (경희대학교 한의과대학 예방의학교실) ;
  • 이주아 (세명대학교 한의과대학 내과학교실) ;
  • 고호연 (세명대학교 한의과대학 내과학교실) ;
  • 정희 (경희대학교 한의과대학 예방의학교실) ;
  • 전찬용 (경원대학교 한의과대학 내과학교실) ;
  • 박종형 (경원대학교 한의과대학 내과학교실) ;
  • 김지혜 (경희대학교 한의과대학 예방의학교실) ;
  • 고성규 (경희대학교 한의과대학 예방의학교실) ;
  • 최유경 (경원대학교 한의과대학 내과학교실)
  • Choi, Jung-Won (Department of Orinetal Internal Medicine, College of Oriental Medicine, Kyungwon University) ;
  • Jang, Bo-Hyung (Department of preventivie Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Ju-Ah (Department of Orinetal Internal Medicine, College of Oriental Medicine, Semyung University) ;
  • Ko, Ho-Yeon (Department of Orinetal Internal Medicine, College of Oriental Medicine, Semyung University) ;
  • Jung, Hee (Department of preventivie Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Jun, Chan-Yong (Department of Orinetal Internal Medicine, College of Oriental Medicine, Kyungwon University) ;
  • Park, Jong-Hyung (Department of Orinetal Internal Medicine, College of Oriental Medicine, Kyungwon University) ;
  • Kim, Ji-Hye (Department of preventivie Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Ko, Seong-Gyu (Department of preventivie Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Choi, You-Kyung (Department of Orinetal Internal Medicine, College of Oriental Medicine, Kyungwon University)
  • 발행 : 2009.07.31
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초록

Objective: This study was to investigate the anti-tumor effect, safety, safety, mechanism and metabolizing enzyme of Agrimonia pilosa LEDEB (APL) in female C57B/L mouse tumor (in vivo). Method: First, to evaluate the antitumor activity of APL, we divided the mice into four groups: normal, control, APL50 (50mg/kg), and APL100 (100mg/kg). LLC-obtained American Type Culture Collection was used. LLC had been inoculated to induce tumors. To measure the anti-tumor effect of APL, we calibrated tumor size and weight. To analyze the mechanism of anti-tumor in APL, we used western blotting and to observe metabolizing enzyme in APL we used to real-time PCR. Result: APL50 and APL100 significantly inhibited tumor growth from 12 days after medicine injected. APL did not induce caspase-dependent apoptosis in LLC-bearing mouse tumor. In APL100, it decreased 41% and 71% in CYP2D22 and CYP3A11, respectively. Conclusion: These results suggest that APL has some anti-tumor effects in female C57B/L mouse tumor. APL should be used carefully with other drugs related with CYP2D22 and CYP3A11.

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