Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effect of Garlic and Medicinal Plants Composites on the Liver Function and Lipid Metabolism of Rats Administered with Ethanol During the Short-term

단기 알코올 투여 시 마늘과 한약재 복합물이 체내 지질 조성 및 간기능 회복에 미치는 영향

  • Kang, Min-Jung (Namhae Garlic Research Institute) ;
  • Shin, Jung-Hye (Namhae Garlic Research Institute) ;
  • Lee, Soo-Jung (Dept. of Food Science and Nutrition, Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Chung, Mi-Ja (The Nutraceutical Bio Brain Korea 21 Project Group, Kangwon National University) ;
  • Sung, Nak-Ju (Dept. of Food Science and Nutrition, Gyeongsang National University Namhae Garlic Research Institute)
  • 강민정 ((재)남해마늘연구소) ;
  • 신정혜 ((재)남해마늘연구소) ;
  • 이수정 (경상대학교 식품영양학과.농업생명과학연구원) ;
  • 정미자 (강원대학교 BK21 사업단.뉴트라슈티컬바이오) ;
  • 성낙주 (경상대학교 식품영양학과.(재)남해마늘연구소)
  • Published : 2009.07.30
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Abstract

This study was performed to observe the effect of hot-water extracts from garlic and 13 kinds of medicinal plants composites (GMP) on hyperlipidemia and hepatoprotective activity in rats administered with alcohol. Male Sprague-Dawly rats were fed an AIN-93 diet (Normal), a normal diet plus ethanol (control, 10 ml of 40% ethanoljkgjday), a control diet plus 0.5% garlic and 1.0% medicinal plants composites extracts (GMP-I), and a control diet plus 1.0% garlic and medicinal plants composites extracts (GMP-II) for 7 days. Blood glucose was higher than the control, but it was markedly decreased in the GMP-II group. Elevation total lipids, cholesterol, triglyceride and phospholipids in serum were markedly decreased in rats fed with GMP-I. GMP-II also inhibited the increase of lipid content in serum. Activities of GOT, GPT, $\gamma$-GTP and ALP in serum elevated by alcohol were significantly inhibited in the GMP group. TBARS content of serum was significantly decreased in GMP groups administered with garlic and medicinal plant extracts. Extracts of garlic and medicinal plants play an important role in recovering liver function in rats from alcohol induced damage.

40% 알코올을 1주간 경구투여한 후 마늘 및 한약재 복합물을 각각 0.5%와 1%(GMP-I) 및 1%씩 (GMP-II) 식이에 혼합하여 3주간 급이하였을 때, 흰쥐의 체내 지질 성분 및 간 기능에 미치는 영향을 분석하였다 in vitro상에서 마늘 추출물의 ADH 활성은 20% 알코올농도에서 시료의 첨가량이 많아질수록 유의적으로 활성이 증가하였다. ALDH 활성은 마늘 추출물 첨가 시 무첨가구보다 활성이 낮았으나, 한약재 추출물 첨가 시 40%의 알코올농도에서 시료 첨가량의 증가에 따라 유의적으로 상승되었다. 알코올 투여 흰쥐에서 혈당은 마늘과 한약재 복합물의 급이시 마늘의 급이량이 많아질수록 혈당 저하에 효과적이었다. 혈중 총 지질, 총 콜레스테롤, 중성지방 및인지질은 마늘과 한약재 복합물 급이군에서 유의적으로 감소되었으며, 마늘의 첨가량이 많아질수록 체내 지질 감소 효과가 높았다. GOT, GPT, r-GTP 및 ALP 활성은 마늘 및 한약재 복합물의 급이로 대조군에 비해 유의적으로 감소되었다. 혈중 TBARS 함량은 마늘 및 한약재 복합물 급이 시 대조군에 비해 유의적으로 감소되었다. 간조직의 총 지질, 총 콜레스테롤 및 중성지방도 마늘 및 한약재 복합물 급이시 유의적으로 감소되었으며, TBARS 함량은 마늘의 첨가량이 증가될수록 생성이 억제되었다.

Keywords

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