Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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The Effect of Risedronate on Posterior Lateral Spinal Fusion in a Rat Model

  • Gezici, Ali Riza (Department of Neurosurgery, Faculty of Medicine, Abant Izzet Baysal University) ;
  • Ergun, Ruchan (Department of Neurosurgery, Faculty of Medicine, Abant Izzet Baysal University) ;
  • Gurel, Kamil (Department of Radiology, Faculty of Medicine, Abant Izzet Baysal University) ;
  • Yilmaz, Fahri (Department of Pathology, Faculty of Medicine, Abant Izzet Baysal University) ;
  • Okay, Onder (Clinic of Neurosurgery, Ankara Numune Hospital) ;
  • Bozdogan, Omer (Department of Biology, Faculty of Arts and Sciences, Abant Izzet Baysal University)
  • Published : 2009.07.31
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Abstract

Objective : To evaluate the potential effects of risedronate (RIS) which shows a higher anti-resorptive effect among bisphosphonates, after a posterolateral lumbar intertransverse process spinal fusion using both autograft and allograft in a rat model. Methods : A totoal of 28 Sprague-Dawley rats were randomized into 2 study groups. A posterolateral lumbar intertransverse process spinal fusion was peformed using both autograft and allograft in a rat model. Group I (control) received 0.1 mL of steril saline (placebo) and Group II (treatment) received risedronate, equivalent to human dose (10 ${\mu}g$/kg/week) for 10-weeks period. Results : The fusion rates as determined by manual palpation were 69% in the group I and 46% in the group II (p = 0.251). According to radiographic score, the spinal segment was considered to be fused radiographically in 7 (53%) of the 13 controls and 9 (69%) of the 13 rats treated with RIS (p = 0.851). The mean histological scores were 5.69 ${\pm}$ 0.13 and 3.84 ${\pm}$ 0.43 for the control and treatment groups, respectively. There was a significant difference between the both groups (p = 0.001). The mean bone density of the fusion masses was 86.9 ${\pm}$ 2.34 in the control group and 106.0 ${\pm}$ 3.54 in the RIS treatment group. There was a statistical difference in mean bone densities of the fusion masses comparing the two groups (p=0.001). Conclusion : In this study, risedronate appears to delay bone fusion in a rat model. This occurs as a result of uncoupling the balanced osteoclastic and osteoblastic activity inherent to bone healing. These findings suggest that a discontinuation of risedronate postoperatively during acute fusion period may be warranted.

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References

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