Journal of Haehwa Medicine (혜화의학회지)
- Volume 18 Issue 2
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- Pages.47-62
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- 2009
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- 2586-3002(pISSN)
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- 2586-3347(eISSN)
The effects of HYT on various immunological factors related to pathogenesis of allergic dermatitis in NC/Nga mice induced by Biostir AD
아토피피부염 동물 병태모델에서의 형개연교탕(荊芥連翹湯)의 면역조절작용
- Kang, Ran-Yi (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
- Park, Bo-Kyoung (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
- Gim, Seon-Bin (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
- Choi, Hak-Joo (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
- Kim, Dong-Hee (Department of Oriental Pathology, College of Oriental Medicine, Daejeon University)
- 강란이 (대전대학교 한의과대학 병리학교실) ;
- 박보경 (대전대학교 한의과대학 병리학교실) ;
- 김선빈 (대전대학교 한의과대학 병리학교실) ;
- 최학주 (대전대학교 한의과대학 병리학교실) ;
- 김동희 (대전대학교 한의과대학 병리학교실)
- Published : 2009.12.31
Abstract
Atopic dermatitis induced NC/Nga mice were used to investigate the efficacy of HYT on the recovery of dermatitic symptoms by how HYT influenced the immune related factors. The results are as below: 1. Compared to the control, HYT treated group showed recovery of atopic dermatitis by the naked eye observation, and significant reduction of dermatits index was observed after 14 weeks. 2. HYT treated group showed significant decrease of the ratio of CCR3+, B220+/IgE+, and Gr-1+/CD11b+ immune cells in dorsal skin by 40.5%, 34.2%, and 48.1%, respectively. 3. HYT treated group showed increase in the ratio of CD19+ immune cells within PBMC by 10.8%, as well as decrease in CD3+, CD3+/CD69+, NKT+ ratios by 5.3%, 35.2%, and 44.9%, respectively. 4. HYT treated group showed increase in the expression of IFN-