Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Transient Biclonal Gammopathy Associated With Tsutsugamushi Meningitis

쯔쯔가무시 뇌막염과 연관된 이크론성 감마글로불린병증

  • Park, Hyun-Young (Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science) ;
  • Kim, Soo-Seong (Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science) ;
  • Lee, Hak-Seung (Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science) ;
  • Chang, Hyuk (Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science) ;
  • Cho, Kwang-Ho (Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science) ;
  • Kim, Yo-Sik (Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science)
  • 박현영 (원광대학교 의과대학 신경과학교실, 원광의과학연구소) ;
  • 김수성 (원광대학교 의과대학 신경과학교실, 원광의과학연구소) ;
  • 이학승 (원광대학교 의과대학 신경과학교실, 원광의과학연구소) ;
  • 장혁 (원광대학교 의과대학 신경과학교실, 원광의과학연구소) ;
  • 조광호 (원광대학교 의과대학 신경과학교실, 원광의과학연구소) ;
  • 김요식 (원광대학교 의과대학 신경과학교실, 원광의과학연구소)
  • Received : 2009.04.06
  • Accepted : 2009.09.21
  • Published : 2009.12.30
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Abstract

Biclonal gammopathy is characterized by the presence of two different monoclonal immunoglobulins, and the clinical findings of biclonal gammopathy are similar to those of monoclonal gammopathy. An association between biclonal gammopathy and tsutsugamushi meningitis has not been reported previously. Here, we report a case of a 55-year-old man presented with fever and decreased mentality. A cerebrospinal fluid (CSF) test and an indirect immunofluorescent antibody test for Orientia tsutsugamushi revealed tsutsugamushi meningitis. CSF and serum immunofixation electrophoresis revealed biclonal gammopathy (IgG-${\kappa}$, IgG-${\lambda}$). His symptoms improved after antibiotics treatment, and serum biclonal gammopathy completely disappeared.

Keywords

References

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