Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
권호 표지

Overweight of Korean Male Workers and Genetic Polymorphism of Insulin Receptor Substrate 1 (IRS1) Gene

  • Kim, Ki-Woong (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Heo, Kyung-Hwa (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Won, Yong-Lim (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Ko, Kyung-Sun (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Kim, Tae-Gyun (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Lee, Mi-Young (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Park, Jung-Sun (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Paik, Sang-Gi (Department of Biology, Chungnam National University)
  • Published : 2009.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

We have examined the hypothesis that the Gly972Arg variant of the insulin receptor substrate 1 (IRS1) gene is associated with the components contributing to overweight (obesity) and metabolic syndrome. We describe IRS1 genotype frequencies in 274 Korean men. The frequencies of Gly972Gly (GIG) and Gly972Arg (G/A variant) of the IRS1 gene were 88.3% and 11.7%, respectively, and the differences in frequencies between the overweight (BMI$\geq$25kg/m$^2$) group and non-overweight (BMI<25kg/m$^2$) group were statistically significant. The subjects with G/A variant of IRS1 gene in non-overweight had significantly higher level of visceral fat thickness and adiponectin/leptin ratio than those with GIG alleles. In overweight group, the subjects with G/A variant of IRS1 gene also showed significantly higher level of insulin than those with GIG alleles. These results suggest that the IRS1 genetic polymorphism is involved in the occurrence of overweight, as well as metabolic syndrome.

Keywords

References

  1. Almind K, Bjorbaek C, Vestergaard H, Hansen T, Echwald S, and Pedersen O (1993) Amino acid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. Lancet 342 (8875): 828-832 https://doi.org/10.1016/0140-6736(93)92694-O
  2. Aranceta J (2003) Community nutrition. Eur J Clin Nutr 57 Suppl 1: S79-S81 https://doi.org/10.1038/sj.ejcn.1601823
  3. Saba T, Endo T, Sata F, Honnma H, Kitajima Y, Hayashi T, Manase K, Kanaya M, Yamada H, Minakami H, Kishi R, and Saito T (2007) Polycystic ovary syndrome is associated with genetic polymorphism in the insulin signaling gene IRS-1 but not ENPP1 in a Japanese population. Life Sci 81: 850-854 https://doi.org/10.1016/j.lfs.2007.07.023
  4. Boon YK, Najimudin N, and Muhammad TS (2008) The PPAR$\gamma$ coding region and its role in visceral obesity. Biochem Biophys Res Commun 371: 177-179 https://doi.org/10.1016/j.bbrc.2008.04.013
  5. Chung WK and Leibel RL (2005) Molecular physiology of syndromic obesities in humans. Trends Endocrinol Metab 16: 267-272 https://doi.org/10.1016/j.tem.2005.06.009
  6. Centers for Disease Control and Prevention (CDC).(2006) State specific prevalence of obesity among adults-United States, 2005. MMWR Morb Mortal Wkly Rep 55: 985-988
  7. Clement K (2006) Genetics of human obesity. C R BioI 329: 608-622 https://doi.org/10.1016/j.crvi.2005.10.009
  8. de Boer J, Hoogland CT, and Boersema JJ (2007) Towards more sustainable choices: Value priorities and motivational orientations. Food Qual Prefer 18: 985-996 https://doi.org/10.1016/j.foodqual.2007.04.002
  9. Demographic and Health Survey (2003) Department of Health, online. Availableat
  10. Despres JP and Lemieux I (2006) Abdominal obesity and metabolic syndrome. Nature 444: 881-887 https://doi.org/10.1038/nature05488
  11. Fallucca F, Dalfra MG, Sciullo E, Masin M, Buongiorno AM, Napoli A, Fedele D, and Lapolla A (2006) Polymorphisms of insulin receptor substrate I and ${\beta}_{3}$-adrenergic receptor genes in gestational diabetes and normal pregnancy. Metabolism 55: 1451-1456 https://doi.org/10.1016/j.metabol.2006.06.004
  12. Hill JO and Peters JC (1998) Environmental contributions to the obesity epidemic. Science 280: 1371-1374 https://doi.org/10.1126/science.280.5368.1371
  13. Hitman GA, Hawrami K, McCarthy MI, Viswanathan M, Snehalatha C, Ramachandran A, Tuomilehto J, TuomilehtoWolf E, Nissinen A, and Pedersen O (1995) Insulin receptor substrate-I gene mutations in NIDDM; implications for the study of polygenic disease. Diabetologia 38: 481-486 https://doi.org/10.1007/BF00410287
  14. Ichihara S, Yamada Y, Kato K, Hibino T, Yokoi K, Matsuo H, Kojima T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Yasunaga A, Park H, Tanaka M, and Nozawa Y (2008) Association of a polymorphism of ABCB1 with obesity in Japanese individuals. Genomics 91: 512-516 https://doi.org/10.1016/j.ygeno.2008.03.004
  15. Ikarashi T, Hanyu O, Maruyama S, Souda S, Kobayashi C, Abe E, Ukisu J, Naganuma K, Suzuki A, Toya M, Kaneko S, Suzuki K, Nakagawa O, and Aizawa Y (2004) Genotype Gly/Gly of the Argl6Gly polymorphism of the ${\beta}_{2}$-adrenergic receptor is associated with elevated fasting serum insulin concentrations, but not with acute insulin response to glucose, in type 2 diabetic patients. Diabetes Res Clin Pract 63: 11-18 https://doi.org/10.1016/j.diabres.2003.08.010
  16. Jellema A, Zeegers MP, Feskens EJ, Dagnelie PC, and Mensink RP (2003a) Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a metaanalysis of 27 studies. Diabetologia 46: 990-995 https://doi.org/10.1007/s00125-003-1126-4
  17. Jellema A, Mensink RP, Kromhout D, Saris WHM, and Feskens EJ (2003b) Metabolic risk markers in an overweight and normal weight population with oversampling of carriers ofthe IRS-1 972Arg-variant. Atherosclerosis 171: 75-81 https://doi.org/10.1016/j.atherosclerosis.2003.08.002
  18. Korea Ministry of Health and Welfare (2007) National Health and Nutrition Examination Survey Report
  19. NCEP-ATPIII (2002) 'Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adults Treatment PanelllI) (2002) Final Report.' Circulation 106: 3143-3421
  20. Ogden CL, Yanovski SZ, Carroll MD, and Flegal KM (2007) The epidemiology of obesity. Gastroenterology 132: 2087-2102 https://doi.org/10.1053/j.gastro.2007.03.052
  21. Peeters A, Beckers S, Verrijken A, Roevens P, Peeters P, Van Gaal L, and Van Hul W (2008) Variants in the FTO gene are associated with common obesity in the Belgian population. Mol Genet Metab 93: 481-484 https://doi.org/10.1016/j.ymgme.2007.10.011
  22. Prentice AM and Jebb SA (2003) Fast food, energy density and obesity: A possible mechanistic link. Obes rev 4: 187-194 https://doi.org/10.1046/j.1467-789X.2003.00117.x
  23. Pyorala M, Miettinen H, Halonen P, Laakso M, and Pyorala K (2000) Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Arterioscler Thromb Vasc Biol 20: 538-544 https://doi.org/10.1161/01.ATV.20.2.538
  24. Reaven GM (1988) Banting lecture 1988. Role of insulin resistance in hwnan disease. Diabetes 37: 1595-1607 https://doi.org/10.2337/diabetes.37.12.1595
  25. Redman LM, Martin CK, Williamson DA, and Ravussin E (2008) Effect of caloric restriction in non-obese hwnans on physiological, psychological and behavioral outcomes. Physiol Behav 94: 643-648 https://doi.org/10.1016/j.physbeh.2008.04.017
  26. Sesti G, Federici M, Hribal ML, Lauro D, Sbraccia P, Lauro R (2001) Defects of the insulin receptor substrate (IRS) system in hwnan metabolic disorders. FASEB J 15: 2099-2111 https://doi.org/10.1096/fj.01-0009rev
  27. Shirakami A, Toyonaga T, Tsuruzoe K, Shirotani T, Matswnoto K, Yoshizato K, Kawashima J, Hirashima Y, Miyamura N, Kahn CR, and Araki E (2002) Heterozygous knockout ofthe IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes. J Endocrinol 174: 309-319 https://doi.org/10.1677/joe.0.1740309
  28. Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, and White MF (1991) Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352: 73-77 https://doi.org/10.1038/352073a0
  29. White MF and Kahn R (1994) The insulin signaling system. J Biol Chem 269: 1-4
  30. Xita N, Papassotiriou I, Georgiou I, VounatsouM, Margeli A, and Tsatsoulis A (2007) The adiponectin-to-leptin ratio in women with polycystic ovary syndrome: relation to insulin resistance and prointlammatory markers. Metabolism 56: 766-771 https://doi.org/10.1016/j.metabol.2007.01.008
  31. Yamada Y, Kato K, Hibino T, Yokoi K, Matsuo H, Segawa T, Watanabe S, Ichihara S, Yoshida H, Saroh K, and Nozawa Y (2007) Prediction of genetic risk for metabolic syndrome. Atherosclerosis 191: 298-304 https://doi.org/10.1016/j.atherosclerosis.2006.05.035
  32. Yoon H-J and Lee S-K (2006) Effect of home-visit nutrition education for the elderly with high fasting blood glucose levels. Korean J Community Nutrition 11: 346-360