The Relationship between Stress Response and Oxidative Stress among Healthy Volunteers

정상인에서의 스트레스 반응 정도와 산화스트레스 사이의 상관관계 연구

  • Byun, Soon-Im (Graduate School of Kyunghee University) ;
  • Kim, Ji-Young (Graduate School of Kyunghee University) ;
  • Cho, Seung-Hun (Department of Neuropsychiatry, College of Oriental Medicine, Kyunghee University) ;
  • Kim, Jong-Woo (Department of Neuropsychiatry, College of Oriental Medicine, Kyunghee University) ;
  • Hwang, Wei-Wan (Department of Neuropsychiatry, College of Oriental Medicine, Kyunghee University)
  • 변순임 (경희대학교 대학원) ;
  • 김지영 (경희대학교 대학원) ;
  • 조성훈 (경희대학교 한의과대학 신경정신과학교실) ;
  • 김종우 (경희대학교 한의과대학 신경정신과학교실) ;
  • 황의완 (경희대학교 한의과대학 신경정신과학교실)
  • Received : 2009.07.12
  • Accepted : 2009.08.06
  • Published : 2009.08.30

Abstract

Objective : This study was to examine a relationship among subjective psychological stress, physical stress response and oxidative stress. Methods : The subjects were consisted of 87 healthy volunteers. To assess subjective psychological stress, SRI(stress response inventory) was completed. To assess psychological and physical stress response, HRV(Heart Rate Variability) were tested. To assess oxidative stress, d-roms(Derivatives of reactive oxygen metabolites test) test was conducted. Subjects were divided into 3 groups depending on SRI(Stress Response Inventory) score, low stress response(LSR: lower than 30 percentile), Medium(MSR: 30-70 percentile) and high stress response(HSR: higher than 70 percentile). The Relationship between Stress Response and Oxidative Stress was estimated by correlation and One-way ANOVA analysis. Results : There were no significant differences of demographic data among 3 groups. There was a significant difference of oxidative stress among 3 groups. Conclusion : Our results suggest that there is a weak positive correlation between subjective psychological stress and oxidative stress. There is a significant difference of oxidative stress between HSR group and LSR group.

Keywords

References

  1. 최병기, 정세영, 박광식, 조정희. 활성산소와 질환. 도서출판 신일상사. 2004.
  2. Wells-Federman CV, Stuart EM, Deckro JP, Mandle CL, Baim M, Medich C. The mind-body connections : The psychophysiology of many traditional nursing intervention. Clinical Nurse Specialist 1995 : 9 ; 59-66. https://doi.org/10.1097/00002800-199501000-00017
  3. 채영란, 스트레스에 의한 면역기능의 변화, 스트레스 연구, 2005 : 13(3) ; 133-140.
  4. Moller P, Wallin H, Knudsen LE. Oxidative stress associated with exercise, psychological stress and life-style factors. Chem Biol Interact. 1996 : 102(1) ; 17-36. https://doi.org/10.1016/0009-2797(96)03729-5
  5. Masahiro Irie, Shinya Asami, Shoji Nagata, Masakazu Miyata, Hiroshi Kasai. Relationships between perceived workload, stress and oxidative DNA damage. Int Arch Occup Environ Health. 2001 : 74 ; 153-157. https://doi.org/10.1007/s004200000209
  6. Lesgards J-F, Durand P, Lassarre M, Stocker P, Lesgards G, Lanteaume A, Prost M, Lehucher-Michel M-P. Assessment of lifestyle effects on the overall antioxidant capacity of healthy subjects. Environ Health Perspect. 2002 : 110 ; 479-486. https://doi.org/10.1289/ehp.02110479
  7. John R. Hapuarachchi, Ainsley H, Chalmers, Anthony H. Winefield, Jane S. Blake-Mortimer. Changes in Clinically Relevant Metabolites With Psychological Stress Parameters. Behavioral Medicine. 2003 : 29 ; 52-59. https://doi.org/10.1080/08964280309596057
  8. A. Bierhaus, NF-${\kappa}$B as a molecular link between psychosocial stress and organ dysfunction. Pediatr Nephrol. 2004 : 19 ; 1189-1191. https://doi.org/10.1007/s00467-004-1603-0
  9. Monika Sivonova, Ingrid Zitnanova, Lucia Hlincikova, Igor Skodacek, Jana Trebaticka, Zdenka Durackova. Oxidative stress in university students during examinations. Stress. 2004 : 7(3) ; 183-188. https://doi.org/10.1080/10253890400012685
  10. 강주영. 요가 운동이 어깨 근막동통증후군 환자의 근기능과 통증 및 활성산소에 미치는 영향. 한국체육대학교 사회체육대학원 건강관리학과 석사학위논문. 2006.
  11. V.Lubrano, C. Vassalle, A.L'Abbate, G.C.Zucchelli. A new method to evaluate oxidative stress in humans. Immunoanalyse& Bilolgie specililsee 2002 : 17 ; 172-175. https://doi.org/10.1016/S0923-2532(02)01188-2
  12. Alberti A. d-roms test : model and chemical basis National Council of Research. Research Area. Bologna, Italy, 1997.
  13. 고경봉, 박중규, 감찬형. 스트레스 반응 척도의 개발, 신경정신의학. 2000 : 39(4) ; 707-719.
  14. 최환석, 스트레스 평가방법으로서의 HRV의 이용, 스트레스 연구 2005 : 13(2) ; 59-63.
  15. 김경택. 천왕보심단이 산화스트레스에 미치는 영향에 대한 무작위배정, 이중맹검, 위약대조군 임상연구. 경희대학교 대학원 한의학과 석사학위논문 2008;19.
  16. Kennett G. A., S.L. Dickinson, G. Curson. Enhancement of some 5-HTdependent behavioral responses following repeated immobilization in rats. Brain Research, 1985 : 330 ; 253-263. https://doi.org/10.1016/0006-8993(85)90684-5
  17. Odio M.R. and R.P. Maickel. Comparative biochemical responses of rats to different stressful stimuli. Physiology and Behavior. 1985 : 34 ; 596-599.
  18. Guyton A. C. Textbook of medical physiology. 1991. W. B. Saunders Company.
  19. 정명희. 산소란 유익한 것인가?. 의학총설. 1990 : 1(2) ; 24-41.
  20. Brian E.L., B.C. Siegel. Aspects of free radical reaction in biological system - Aging. J. Gerontology. 1980 : 35(1) ; 45-56. https://doi.org/10.1093/geronj/35.1.45
  21. 임향희. 청혈단이 산화 스트레스에 미치는 영향에 대한 무작위 할당 이중맹검 위약 대조군 임상연구. 경희대학교 대학원 한의학과 석사학위논문 2008.
  22. Shuichi Adachi, Ken Kawamura, Kazuo Takemoto. Oxidative Damage of Nuclear Dna in Liver of Rats Exposed to Psychological Stress. Cancer Research, 1993 : 53 ; 4153-4155.
  23. Moller P, Wallin H, Knudsen LE. Oxidative stress associated with exercise, psychological stress and life-style factors. Chem Biol Interact. 1996 : 102(1) ; 17-36 https://doi.org/10.1016/0009-2797(96)03729-5
  24. 양춘호, 한승혜. 습관적 운동과 스트레스 수준이 항산화 효소 활성도에 미치는 영향. 한국스포츠리서치. 2005 : 16(3) ; 133-142.
  25. Thayer JF, Friedman BH, Borkovec TD. Autonomic characteristics of generalized anxiety disorder and worry. Soc Bio Psych. 1996 : 39 ; 255-266. https://doi.org/10.1016/0006-3223(95)00136-0
  26. Trotti R., Carratelli M., Barbieri M. Performance and clinical application of a new, fast method for the detection of hydroperoxides in serum. Panminerva Med. 2002 : 44(1) ; 37-40.
  27. Cesarone MR, Belcaro G, Carratelli M, Cornelli U, De Sanctis MT, Incandela L, Barsotti A, Terranova R, Nicolaides A.A. simple test to monitor oxidative stress. Int Anqiol, 1999 : 18(2) ; 127-30.