대한본초학회지 (The Korea Journal of Herbology)

  • 제24권2호
  • /
  • Pages.67-76
  • /
  • 2009
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  • 1229-1765(pISSN)
  • /
  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지
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한국독활(韓國獨活)과 중국독활(中國獨活)의 항산화효능 비교 연구

Comparative Studies on the Anti-oxidation Activities of Aralia continentalis Root and Angelica pubescens Root

  • 신명섭 (경원대학교 한의과대학 본초학교실) ;
  • 한효상 (경원대학교 한의과대학 본초학교실) ;
  • 이영종 (경원대학교 한의과대학 본초학교실)
  • Shin, Myoung-Soup (Dept of Herbology, College of Oriental Medicine, Kyungwon University) ;
  • Han, Hyo-Sang (Dept of Herbology, College of Oriental Medicine, Kyungwon University) ;
  • Lee, Young-Jong (Dept of Herbology, College of Oriental Medicine, Kyungwon University)
  • 발행 : 2009.06.30
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초록

Objectives : The present study compared Aralia continentalis Root and Angelica pubescens Root used in Korea and China respectively concerning their anti-oxidant effect Methods : We tested the anti-oxidant effect through in vitro experiment and in vivo experiment that induced oxidative stress using ethanol. Results : 1. DPPH scavenging activity was stronger in Aralia continentalis Root than in Angelica pubescens Root 2. Superoxide anion radical scavenging activity was similar between Aralia continentalis Root and Angelica pubescens Root 3. The linoleic acid peroxidation inhibition effect was stronger in Aralia continentalis Root than in Angelica pubescens Root. 4. The phenolic component was higher in Aralia continentalis Root than in Angelica pubescens Root. 5. Both Aralia continentalis Root and Angelica pubescens Root increased the concentration of GSH and decreased SOD activity in mice, in which oxidative stress was induced, and the effect was stronger in Aralia continentalis Root. 6. Aralia continentalis Root increased GSH peroxidase activity but Angelica pubescens Root did not have such an effect. 7. Neither Aralia continentalis Root nor Angelica pubescens Root had a significant effect on catalase, ADH and ALDH in mice, in which oxidative stress was induced. Conclusions : Aralia continentalis Root has a stronger anti-oxidant effect than Angelica pubescens Root. Thus, although Aralia continentalis Root is not an original plant recorded in botanical literature, it may be usable based on the data about its effects.

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참고문헌

  1. 孫星衍 輯. 神農本草經. 北京 : 科學技術文獻出版社. 1999 : 16.
  2. 全國韓醫科大學 本草學共同敎材編纂委員會 編. 本草學. 서울 : 영림사. 2004 : 305-6.
  3. 지형준, 이상인, 안덕균, 이경순, 이숙연, 이영종 편. 대한약전 및 대한약전외 한약규격주해 제2개정. 서울 : 한국메디칼인덱스사. 1998 : 185.
  4. 中華人民共和國 衛生部 藥典委員會 編. 中華人民共和國 藥典. 北京 : 化學工業出版社. 2005 : 215-6.
  5. 行政院 衛生署 編. 中華民國中藥典範 1985年版. 臺北 : 達昌印刷有限公司. 1985 : 290, 291.
  6. 조선민주주의인민공화국 보건부 약전위원회. 조선민주주의인민공화국 약전 제5판. 평양 : 의학과학출판사. 1996 : 287-8.
  7. 厚生省 藥務局 審査第二科 監修. 日本藥局方外生藥規格. 東京 : 藥事日報社. 1989 : 23, 64.
  8. 國家中醫藥管理局 中華本草編委會. 中華本草. 上海 : 上海科學技術出版社. 1999 ; (5) : 782-5, 877-81.
  9. 한용남, 한병훈, 이은옥, 박명환, 한기애. 獨活의 항염증 유효 성분 Continentalic acid 화학구조. 생약학회지. 1982 ; 13(4) : 169.
  10. 김길웅, 백경환. 獨活(Aralia continentalis root)로부터 생장억제물질의 분리 및 동정. 韓國雜草學會誌. 1990 ; 10(3) : 221-6.
  11. Hata K, Kozawa M. The formation of angelical from angelol, a new coumarin isolated from the root of Angelica pubescens Maxim. (umbelliferae). Yakugaku Zasshi. 1967 ; 87(2) : 210-1.
  12. Hata K, Nishino T, Hirai Y, Wada Y, Kozawa M. On coumarins from the fruits of Angelica pubescens Maxim (author's transl). Yakugaku Zasshi. 1981 ; 101(1) : 67-71. https://doi.org/10.1248/yakushi1947.101.1_67
  13. Ko FN, Wu TS, Liou MJ, Huang TF, Teng CM. Inhibition of platelet thromboxane formation and phosphoinositides breakdown by osthole from Angelica pubescens. Thromb Haemost. 1989 ; 62(3) : 996-9.
  14. Ko FN, Wu TS, Liou MJ, Huang TF, Teng CM. Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens root. Eur J Pharmacol. 1992 ; 219(1) : 29-34. https://doi.org/10.1016/0014-2999(92)90576-P
  15. Guh JH, Yu SM, Ko FN, Wu TS, Teng CM. Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens root. Eur J Pharmacol. 1996 ; 298(2) : 191-7. https://doi.org/10.1016/0014-2999(95)00812-8
  16. Teng CM, Lin CH, Ko FN, Wu TS, Huang TF. The relaxant action of osthole isolated from Angelica pubescens in guinea-pig trachea. Naunyn Schmiedebergs Arch Pharmacol. 1994 ; 349(2) : 202-8.
  17. Chen YF, Tsai HY, Wu TS. Anti-inflammatory and analgesic activities from roots of Angelica pubescens. Planta Med. 1995 ; 61(1) : 2-8. https://doi.org/10.1055/s-2006-957987
  18. Okuyama E, Nishimura S, Ohmori S, Ozaki Y, Satake M, Yamazaki M. Analgesic component of Notopterygium incisum Ting. Tokyo : Chem Pharm Bull. 1993 ; 41(5) : 926-9. https://doi.org/10.1248/cpb.41.926
  19. Lee SE, Seong NS, Park CG, Seong JS. Screening for antioxidative activity of oriental medicinal plant materials. Korean J Medicinal Crop Sci. 2002 ; 10 : 171-6.
  20. Nishikimi N, NA Rao, and K Yagi. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygenin Biochem. Biophys Res Commun. 1972 ; 46 : 849. https://doi.org/10.1016/S0006-291X(72)80218-3
  21. HK Hashimoto and A Yagi. Antioxidative substances in leaves of Polygonum hydropiper. J Agric Food Chem. 1992 ; 40 : 1349-51. https://doi.org/10.1021/jf00020a011
  22. Kim NM, Sung HS, Kim WJ. Effect of solvents and some extraction conditions on antioxidant activity in cinnamon extracts. Korean J Food Sci Technol. 1993 ; 25 : 204-9.
  23. Ellman GL. Tissue sulfhydryl group. Arch Biochem Biophys. 1950 ; 82 : 79.
  24. Flohe' L, Miguel J, AT Quintanilha, H Weber (eds.). Determination of glutathione peroxidase. In Handbook of Free Radicals and Antioxidants in Biomedicine, Vol. III. CRC Press. 1989 : 283, 284.
  25. Pttichis K, LL Louca and V Glover. Quantitation of soluble Superoxide dismutase in rat, based on the inhibition of ritrite formation from hydroxylammonium chloride. Anal Biochem. 1994 ; 221 : 428-31. https://doi.org/10.1006/abio.1994.1441
  26. Abei H, L Packer(ed). Catalase in vitro, In "Methods in enzymology(vol. 5)". Academic Press. 1984 : 121-6.
  27. Tottmar SOC, Pettersson H, Kiessling KH. The subcellular distribution and properties of aldehyde dehydrogenase in rat liver. Biochem J. 1973 : 135, 577-6. https://doi.org/10.1042/bj1350577a
  28. 陶弘景 集, 尙志均 輯校. 名醫別錄. 北京 : 人民衛生出版社. 1986 : 16.
  29. 尙志鈞 輯校. 新修本草. 合肥 : 安徽科技出版社. 1981 : 165.
  30. 蘇頌 撰, 胡乃長, 王致譜 輯注. 圖經本草 輯復本. 福建 : 龍源出版公社. 1988 : 94-5.
  31. 許浚. 東醫寶鑑. 서울 : 南山堂. 1986 : 721.
  32. 江蘇新醫學院 編. 中藥大辭典. 上海 : 商務印書館 香港分館. 1979 : 1703-6.
  33. 李愚喆. 韓國植物名考. 서울 : 아카데미서적. 1996 : 771.
  34. Zhuravlev IuN, Artiukova EV, Kozyrenko MM, Reunova GD. Genetic relationships among Far Eastern species of the family Araliacea inferred by RAPD analysis. Genetika. 2003 ; 39(1) : 57-63.
  35. 이택수, 이명환, 강삼식, 최재수, 김주선. 땃두릅(Aralia continen- talis)의 항산화 성분. 생약학회지. 1998 ; 29(1) : 13-7.
  36. Lee GI, Ha JY, Min KR, Nakagawa H, Tsurufuji S, Chang IM, Kim Y. Inhibitory effects of Oriental herbal medicines on IL-8 induction in lipopolysaccharide-activated rat macrophages. Planta Med. 1995 ; 61(1) : 26-30. https://doi.org/10.1055/s-2006-957992
  37. Dang NH, Zhang X, Zheng M, Son KH, Chang HW, Kim HP, Bae K, Kang SS. Inhibitory constituents against cyclooxygenases from Aralia cordata Thunb. Arch Pharm Res. 2005 ; 28(1) : 28-33. https://doi.org/10.1007/BF02975131