The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Active Effect of Antivoagulant Effects in chaenomelis Fructus Water Extract

모과 추출물의 항응혈 활성

  • Yoo, Ji-Hyun (Active Effect of Anticoagulant Effects in Chaenomelis Fructus Water Extract) ;
  • Han, Sin-Hee (Active Effect of Anticoagulant Effects in Chaenomelis Fructus Water Extract) ;
  • Kil, Gi-Jung (Active Effect of Anticoagulant Effects in Chaenomelis Fructus Water Extract)
  • Published : 2009.06.30
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Abstract

Objectives : This research was investigated anticoagulant effect of the Chaenomelis Fructus extract. Methods : To examine an active effect of anticoagulation in Chaenomelis Fructus extract, the study measured Prothrombin time(PT) and activated partial thromboplastin time (APTT) of human plasma in vitro and measured bleeding time and arterio-venous shunt model in rats in vivo. Results : Bleeding time of Chaenomelis Fructus extract in vivo had a significant increase as about 1.6 times and thrombus weight of Chaenomelis Fructus extract had a significant reduction of thrombus weight as 50%. Chaenomelis Fructus extract represented an effect of anticoagulation by operating on extrinsic pathway factor II, V, VII, X and intrinsic pathway factor VIII, IX, X, XI, XII in the coagulation system. Conclusions : Considering the above mentioned results, it is judged that a Chaenomelis Fructus extract has a control effect of thrombus creation.

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References

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