대한본초학회지 (The Korea Journal of Herbology)

  • 제24권2호
  • /
  • Pages.1-5
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  • 2009
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
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DNCB로 유발된 알레르기성 접촉피부염에 황련해독탕이 미치는 영향

Effect of Hwangryunhaedok-tang Extracts on DNCB-induced Allergic Contact Dermatitis

  • 김보애 (대구한의대학교 화장품약리학과) ;
  • 양재찬 (LG생활건강 화장품연구소) ;
  • 박찬익 (대구한의대학교 화장품약리학과 화장품신제형연구실)
  • Kim, Bo-Ae (Dep. of Cosmeceutical Science, Daegu Haany University) ;
  • Yang, Jae-Chan (Cosmetic R&D Institute, LG Household & Health Care) ;
  • Park, Chan-Ik (Dep. of Cosmeceutical Science, Daegu Haany University)
  • 발행 : 2009.06.30
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초록

Objectives : HRHDT has been known as a useful prescription with antibiotic, anti-inflammatory, antioxidative and immunosuppressive activity. To evaluate anti-inflammatory effect of HRHDT, we treated HRHDT-skin in Balb/c mice model induced contact hypersensitivity. Methods : Contact hypersensitivity, a local inflammatory respinse of skin, was induced by spreading the back skin of Balb/c mice with 1% DNCB. HRHDT-skin was prepared by dissolving 3% 1,3-butylene glycol extract of HRHDT in solution and treated 2 weeks on the back skin. Results: HRHDT-skin significantly reduced TEWL and erythema by 0.4-1% of DNCB treatment compared with control group. HRHDT-skin reduced IgE on serum obtained from blood of DNCB-treated Balb/c mice. Histopathological examination showed that thickening of the epidermis, hyperkeratosis and the infiltration of inflammatory cells were found in Balb/c mice under conventional circumstances. Conclusions : These results showed that HRHDT-skin could be used as a pharmaceutical material with antiinflammatory effects by reducing IgE in contact hypersensitivity dermatitis Balb/c mice by DNCB.

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