Reproductive and Developmental Biology
- Volume 33 Issue 2
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- Pages.77-83
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- 2009
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- 1738-2432(pISSN)
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- 2288-0151(eISSN)
Development and Characterization of Hyperglycosylated Recombinant Human Erythropoietin (HGEPO)
- JarGal, Naidansuren (Animal Biotechnology, Graduate School of Bio. & Information Technology, Hankyong National University) ;
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Min, Kwan-Sik
(Animal Biotechnology, Graduate School of Bio. & Information Technology, Hankyong National University)
- Received : 2009.06.11
- Accepted : 2009.06.17
- Published : 2009.06.30
Abstract
Erythropoietin (EPO), a glycoprotein hormone produced from primarily cells of the peritubular capillary endothelium of the kidney, is responsible for the regulation of red blood cell production. We have been investigating the roles of glycosylation site added in the biosynthesis and function of recombinant protein. We constructed three EPO mutants (