Journal of Periodontal and Implant Science

  • 제39권2호
  • /
  • Pages.157-166
  • /
  • 2009
  • /
  • 2093-2278(pISSN)
  • /
  • 2093-2286(eISSN)
대한치주과학회 (Korean Academy of Periodontology)
권호 표지

비외과적.외과적 치주치료와 병행 투여된 비타민 C 특수영양 보충용 식품이 치주질환의 치유과정에 미치는 효과

The effect of vitamin-C containing neutraceutical on periodontal wound healing as an adjunct to non-surgical or surgical periodontal treatment

  • 백영란 (경북대학교 치의학전문대학원 치주과학교실) ;
  • 박진우 (경북대학교 치의학전문대학원 치주과학교실) ;
  • 이재목 (경북대학교 치의학전문대학원 치주과학교실) ;
  • 서조영 (경북대학교 치의학전문대학원 치주과학교실)
  • Baek, Young-Ran (Department of Periodontology, School of Dentistry, Kyungpook National University) ;
  • Park, Jin-Woo (Department of Periodontology, School of Dentistry, Kyungpook National University) ;
  • Lee, Jae-Mok (Department of Periodontology, School of Dentistry, Kyungpook National University) ;
  • Suh, Jo-Young (Department of Periodontology, School of Dentistry, Kyungpook National University)
  • 발행 : 2009.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: There are numerous reports about the usefulness of antibiotics such as doxycycline or metronidazole in the conventional treatment for the patients with chronic periodontal diseases. However, seldom are the reports about effects of vitamins or nutraceuticals. The purpose of this study was to evaluate the effects of nutrient supplement including multiple vitamins and neutraceuticals with PRF-K2 from plants and seaweed in treatment of the patients with chronic periodontitis which is needed a nonsurgical or a surgical treatment by evaluating the clinical parameters and the gingival crevicular fluid volume. Methods: The systemically healthy and nonsmoking patients diagnosed with chronic periodontitis were divided into a nonsurgical group and a surgical group. They were also divided into the test group with nutrient supplements and the control group without nutrient supplements. In the nonsurgical group, the clinical parameters (probing depth, clinical attachment level, sulcus bleeding index, and plaque index) and the gingival crevicular fluid volume were checked on baseline, at 1 week, at 3 week and at 9 week after a supplement treatment. In the surgical group, the clinical parameters and the gingival crevicular fluid volume were also checked at 15 week after a surgical treatment. Results: In both nonsurgical and surgical groups, reduction of pocket depth and increment of clinical attachment level were revealed in the test group compared with the control group, but there was not statistically significant difference (p>0.05), and sulcus bleeding index was decreased with statistically significant difference (p<0.05). In addition, plaque index was decreased with statistically significant difference (p<0.05) in the nonsurgical group. Gingival crevicular fluid volume was decreased with statistically significant difference (p<0.05) at week 9 in both non-surgical and surgical groups. Conclusions: In conclusion, our results demonstrate that providing nutrient supplement in both nonsurgical or surgical periodontal treatments may improve gingival inflammation and gingival crevicular fluid.

키워드

참고문헌

  1. Amaliya, Timmerman MF, Abbas F et al. Java project on periodontal diseases: the relationship between vitamin C and the severity of periodontitis. J Clin Periodontol 2007;34:299-304 https://doi.org/10.1111/j.1600-051X.2007.01053.x
  2. Alfano MC. Controversies, perspectives, and clinical implications of nutrition in periodontal disease. Dent Clin North Am 1976;20:519-548
  3. Pedrazzoli V, Kilian M, Karring T, Kirkegaard E. Effect of surgical and non-surgical periodontal treatment on periodontal status and subgingival microbiota. J Clin Periodontol 1991;18:598-604 https://doi.org/10.1111/j.1600-051X.1991.tb00096.x
  4. Becker W, Becker BE, Ochsenbein C et al. A longitudinal study comparing scaling, osseous surgery and modified Widman procedures. Results after one year. J Periodontol 1988;59:351-365 https://doi.org/10.1902/jop.1988.59.6.351
  5. Emingil G, Atilla G, Sorsa T et al. The effect of adjunctive low-dose doxycycline therapy on clinical parameters and gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis. J Periodontol 2004;75:106-115 https://doi.org/10.1902/jop.2004.75.1.106
  6. Akincibay H, Orsal SO, Sengun D, Tozum TF. Systemic administration of doxycycline versus metronidazole plus amoxicillin in the treatment of localized aggressive periodontitis: a clinical and microbiologic study. Quintessence Int 2008;39:33-39
  7. Woolfe SN, Hume WR, Kenney EB. Ascorbic acid and periodontal disease: a review of the literature. J West Soc Periodontol Periodontal Abstr. 1980;28:44-56
  8. Melnick SL, Alvarez JO, Navia JM, Cogen RB, Roseman JM. A case-control study of plasma ascorbate and acute necrotizing ulcerative gingivitis. J Dent Res 1988;67:855-860 https://doi.org/10.1177/00220345880670051201
  9. Neiva RF, Al-Shammari K, Nociti FH Jr, Soehren S, Wang HL. Effects of vitamin-B complex supplementation on periodontal wound healing. J Periodontol 2005;76:1084-1091 https://doi.org/10.1902/jop.2005.76.7.1084
  10. Muroyama K, Murosaki S, Yamamoto Y, Ishijima A, Toh Y. Effects of intake of a mixture of thiamin, arginine, caffeine, and citric acid on adiposity in healthy subjects with high percent body fat. Biosci Biotechnol Biochem 2003;67:2325-2333 https://doi.org/10.1271/bbb.67.2325
  11. Kozik A, Korytowski W, Sarna T, Bloom AS. Interactions of flavins with melanin. Studies on equilibrium binding of riboflavin to dopa-melanin and some spectroscopic characteristics of flavin-melanin complex. Biophys Chem 1990;38:39-48 https://doi.org/10.1016/0301-4622(90)80038-9
  12. Morrow LE, Grimsley EW. Long-term diuretic therapy in hypertensive patients: effects on serum homocysteine, vitamin B6, vitamin B12, and red blood cell folate concentrations. South Med J 1999;92:866-870 https://doi.org/10.1097/00007611-199909000-00003
  13. Aprahamian M, Dentinger A, Stock-Damge C, Kouassi JC, Grenier JF. Effects of supplemental pantothenic acid on wound healing: experimental study in rabbit. Am J Clin Nutr 1985;41:578-589 https://doi.org/10.1093/ajcn/41.3.578
  14. Berg RA, Steinmann B, Rennard SI, Crystal RG. Ascorbatedeficiency results in decreased collagen production: under-hydroxylation of proline leads to increased intracellular degradation. Arch Biochem Biophys 1983;226:681-686 https://doi.org/10.1016/0003-9861(83)90338-7
  15. Alvares O, Siegel I. Permeability of gingival sulcular epithelium in the development of scorbutic gingivitis. J Oral Pathol 1981;10:40-48 https://doi.org/10.1111/j.1600-0714.1981.tb01246.x
  16. Washko P, Rotrosen D, Levine M. Ascorbic acid in human neutrophils. Am J Clin Nutr 1991;54:1221-1227 https://doi.org/10.1093/ajcn/54.6.1221s
  17. Glickman I. Acute vitamin C deficiency and the periodontal tissues; the effect of acute vitamin C deficiency upon the response of the periodontal tissues of the guinea pig to artificially induced inflammation. J Dent Res 1948;27:201-210 https://doi.org/10.1177/00220345480270021401
  18. Russell AL, Leatherwood EC, Consolazio CF, Vanreen R. Periodontal disease and nutrition in South Vietnam. J Dent Res 1965;44:775-782 https://doi.org/10.1177/00220345650440042501
  19. Nishida M, Grossi SG, Dunford RG et al. Dietary vitamin C and the risk for periodontal disease. J Periodontol 2000;71:1215-1223 https://doi.org/10.1902/jop.2000.71.8.1215
  20. Amarasena N, Ogawa H, Yoshihara A, Hanada N, Miyazaki H. Serum vitamin C-periodontal relationship in community-dwelling elderly Japanese. J Clin Periodontol 2005;32:93-97 https://doi.org/10.1111/j.1600-051X.2004.00643.x
  21. Munoz CA, Kiger RD, Stephens JA, Kim J, Wilson AC. Effects of a nutritional supplement on periodontal status. Compend Contin Educ Dent 2001;22:425-428
  22. Kim YK, Chung HJ, Kim SW, Baek DH. The effect of neutraceutical containing PRF-K2 on periodontal condition during maintenance phase. J. Korean Aca Periodontol 2007;37:91-102 https://doi.org/10.5051/jkape.2007.37.1.91
  23. Muhlemann HR, Son S. Gingival sulcus bleeding-a leading symptom in initial gingivitis. Helv Odontol Acta 1971;15:107-113
  24. Silness J, Loe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condtion. Acta Odontol Scand 1964;22:121-135 https://doi.org/10.3109/00016356408993968
  25. Vaxman F, Olender S, Lambert A et al. Effect of pantothenic acid and ascorbic acid supplementation on human skin wound healing process. A double-blind, prospective and randomized trial. Eur Surg Res 1995;27:158-166 https://doi.org/10.1159/000129395
  26. Alvarez OM, Gilbreath RL. Thiamine influence on collagen during the granulation of skin wounds. J Surg Res 1982;32:24-31 https://doi.org/10.1016/0022-4804(82)90180-9
  27. Halliwell B. Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med. 1991;91:14-22
  28. McGowan SE, Parenti CM, Hoidal JR, Niewoehner DE. Ascorbic acid content and accumulation by alveolar macrophages from cigarette smokers and nonsmokers. J Lab Clin Med 1984;104:127-134
  29. Kimura S, Yonemura T, Kaya H. Increased oxidative product formation by peripheral blood polymorphonuclear leukocytes in human periodontal diseases. J Periodontal Res 1993;28:197-203 https://doi.org/10.1111/j.1600-0765.1993.tb01069.x
  30. Parfitt GJ, Hand CD. Reduced plasma ascorbic acid levels and gingival health. J Periodontol 1963;34:47-51 https://doi.org/10.1902/jop.1963.34.1.47
  31. Vogel RI, Lamster IB, Wechsler SA et al. The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis. J Periodontol 1986 ;57:472-479 https://doi.org/10.1902/jop.1986.57.8.472
  32. Leggott PJ, Robertson PB, Rothman DL, Murray PA, Jacob RA. The effect of controlled ascorbic acid depletion and supplementation on periodontal health. J Periodontol 1986;57:480-485 https://doi.org/10.1902/jop.1986.57.8.480
  33. Staudte H, Sigusch BW, Glockmann E. Grapefruit consumption improves vitamin C status in periodontitis patients. Br Dent J 2005;199:213-217 https://doi.org/10.1038/sj.bdj.4812613
  34. Pihlstrom BL, McHugh RB, Oliphant TH, Ortiz-Campos C. Comparison of surgical and nonsurgical treatment of periodontal disease. A review of current studies and additional results after 61/2 years. J Clin Periodontol 1983;10:524-541 https://doi.org/10.1111/j.1600-051X.1983.tb02182.x
  35. Lamster IB. Evaluation of components of gingival crevicular fluid as diagnostic tests. Ann Periodontol 1997;2:123-137 https://doi.org/10.1902/annals.1997.2.1.123
  36. Loe H, Holm-Pedersen P. Absence and presence of fluidfrom normal and inflamed gingivae. Periodontics 1965;149:171-177
  37. Griffiths GS. Formation, collection and significance of gingival crevice fluid. Periodontol 2000 2003;31:32-42 https://doi.org/10.1034/j.1600-0757.2003.03103.x
  38. Minn WK, Lee MS. Effects of ascorbic acid and unsaponifiable fractions of Zea Mays L. on the experimentally induced periodontitis in rats. J. Korean Aca Periodontol 1988;18:6-23
  39. Kwon YH, Lee MS, Yang SH, Kim Y, Park JB. A clinical study of the effects on the healing process of administration of the Zea Mays L. after periodontal surgery. J. Korean Aca Periodontol 1994;24:649-660