Food Science and Preservation (한국식품저장유통학회지)

The Korean Society of Food Preservation (한국식품저장유통학회)
권호 표지

Comparison of Immuno-Suppressive Activities of Pinitol Isolated from Soybean

콩으로부터 추출한 Pinitol의 면역억제 활성 비교

  • Park, Chul-Hong (Department, of Food Science & Technology, Kyungpook National University) ;
  • Heo, Jin-Chul (Department, of Food Science & Technology, Kyungpook National University) ;
  • Nam, Dong-Yun (Department, of Food Science & Technology, Kyungpook National University) ;
  • Lee, Si-Rim (Department, of Food Science & Technology, Kyungpook National University) ;
  • Nam, So-Hyun (Department, of Food Science & Technology, Kyungpook National University) ;
  • Son, Min-Sik (Department, of Food Science & Technology, Kyungpook National University) ;
  • Hwang, Young-Hyun (Department of Agronomy, Kyungpook National University) ;
  • Lee, Sang-Han (Department, of Food Science & Technology, Kyungpook National University)
  • 박철홍 (경북대학교 농업생명과학대학 식품공학과) ;
  • 허진철 (경북대학교 농업생명과학대학 식품공학과) ;
  • 남동윤 (경북대학교 농업생명과학대학 식품공학과) ;
  • 이시림 (경북대학교 농업생명과학대학 식품공학과) ;
  • 남소현 (경북대학교 농업생명과학대학 식품공학과) ;
  • 손민식 (경북대학교 농업생명과학대학 식품공학과) ;
  • 황영현 (경북대학교 농업생명과학대학 식품생명과학부) ;
  • 이상한 (경북대학교 농업생명과학대학 식품공학과)
  • Published : 2009.06.30
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Abstract

The experiment was conducted to validate anti-inflammatory effects of pinitol from bean. It was evaluated for some molecule targets by wound healing assay and RT-PCR. The results of wound healing assay was shown dose-dependent inhibition of cell migration in cancer cells and inhibited RNA expression of ICAM-1, CD 44, MMP-17, MMP-14 and ARF2. Immune suppression activity in a mouse provoked by DNFB observed that inflammatory reaction with pinitol were reduced ear swelling and inflammatory cells infiltration in mouse atopic models. The result confirmed that pinitol have the effect of dose-dependent immune suppression activity.

Keywords

References

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