Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Clinical Characteristics of Korean Daegu . Kyungpook PCOS Women

대구.경북 지역 한국인 다낭성 난소 증후군 환자의 임상 양상

  • Bae, Jin-Young (Kyungpook National University Hospital Department of Obstetrics and Gynecology) ;
  • Kim, Mi-Yeon (Kyungpook National University Hospital Department of Obstetrics and Gynecology) ;
  • Sung, Su-Kyung (Kyungpook National University Hospital Department of Obstetrics and Gynecology) ;
  • Oh, Jeong-Eun (Kyungpook National University Hospital Department of Obstetrics and Gynecology) ;
  • Chun, Sang-Sik (Kyungpook National University Hospital Department of Obstetrics and Gynecology) ;
  • Lee, Taek-Hoo (Kyungpook National University Hospital Department of Obstetrics and Gynecology)
  • 배진영 (경북대학교 병원 산부인과) ;
  • 김미연 (경북대학교 병원 산부인과) ;
  • 성수경 (경북대학교 병원 산부인과) ;
  • 오정은 (경북대학교 병원 산부인과) ;
  • 전상식 (경북대학교 병원 산부인과) ;
  • 이택후 (경북대학교 병원 산부인과)
  • Published : 2009.03.31
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Abstract

Objective: PCOS is one of the most common endocrine disorder affecting reproductive age women. It shows wide range of reproductive and metabolic manifestations. This study was to determine the differences of clinical and laboratory characteristics between adolescent and adult Korean Daegu Kyungpook PCOS patients. We also compared clinical and laboratory values of Korean PCOS patients to Turkish and American PCOS patients. Methods: 88 cases were diagnosed and enrolled as PCOS patients, based on 2003 Rotterdam criteria, who visited KNUH Reproductive Endocrinology division between Jan. 2000 and Apr. 2008. We retrospectively reviewed clinical characteristics, serum hormone levels, ultrasono-graphic findings. And we divided into 2 groups, adolescent and adult. We analyzed them with Chi-square test and Student's t-test statistically. Results: There were no statistically significant differences between adult and adolescent Korean PCOS patients. The prevalence of hyperandrogenism such as facial acne or hirsutism, obesity, and insulin resistance of Korean PCOS women was significantly lower than Turkish and American PCOS women. Conclusion: From the results of this study, we can suggest that it is sure that there are differences of clinical and laboratory characteristics of PCOS patients between races. Genetic background, dietary habits and life style affect the expression of clinical symptoms of PCOS. But we could not find out the difference between adolescent and adult PCOS patients of same race. It might be due to the limitation of small patient number and narrow range of age distribution. So, there must be large scale and multi-center and multi-regional study.

목 적: 다낭성 난소 증후군은 생식기 여성에서 나타나는 가장 흔한 내분비 질환 중 하나이며 다양한 임상 양상을 보이고 있다. 본 연구에서는 한국인 다낭성 난소 증후군 환자 특유의 임상 양상 및 혈액학적 소견을 밝히고자 하였으며 그 결과를 터키와 미국의 다낭성 난소 증후군 환자와 비교 분석하였다. 연구방법: 2000년 1월부터 2008년 4월까지 경북대학교 병원 불임치료실을 찾은 88명의 다낭성 난소 증후군 환자를 대상으로 하여 후향적으로 임상 양상 및 혈액학적 소견을 연구하였다. 결 과: 한국인 다낭성 난소 증후군 환자군 내에서는 통계학적으로 유의한 연령에 따른 임상 양상의 차이가 없었으나 터키와 미국의 다낭성 난소 증후군 환자와 비교했을 때 고안드로겐혈증의 빈도는 유의하게 낮았다. 결 론: 다낭성 난소 증후군 환자 내에서도 인종간의 임상 양상 및 혈액학 소견의 차이가 있다고 생각되며 유전 및 생활 습관의 차이 등이 그 원인을 설명할 수 있을 것이다. 그러나 연구 대상인 환자의 수가 적고 연령군의 분포가 좁아 향후 좀 더 큰 규모의 연구가 필요하다.

Keywords

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