Clinical Analysis and Results after the Amputations of Lower Extremities due to Diabetic Foot

당뇨병성 족부 질환에 의한 하지 절단 후 임상적 분석과 결과

  • Kim, Taik-Seon (Department of Orthopaedic Surgery, Seoul Veterans Hospital) ;
  • Kang, Jong-Woo (Department of Orthopaedic Surgery, College of Medicine, Korea University) ;
  • Lee, Sang-Jun (Department of Orthopaedic Surgery, Seoul Veterans Hospital) ;
  • Huh, Young-Jae (Department of Orthopaedic Surgery, College of Medicine, Korea University) ;
  • Kim, Hak-Jun (Department of Orthopaedic Surgery, College of Medicine, Korea University)
  • 김택선 (서울보훈병원 정형외과) ;
  • 강종우 (고려대학교 의과대학 정형외과학교실) ;
  • 이상준 (서울보훈병원 정형외과) ;
  • 허영재 (고려대학교 의과대학 정형외과학교실) ;
  • 김학준 (고려대학교 의과대학 정형외과학교실)
  • Published : 2009.06.15

Abstract

Purpose: The authors evaluated the clinical results and prognosis after amputating the lower extremity due to diabetic foot. Materials and Methods: From 1991 to 2003, the patients who had suffered amputation of his lower extremity due to diabetic foot ulcer were evaluated retrospectively. 79 patients were male and 6 patients were female. The author evaluated the patient who had the ipsilateral additional surgery, contralateral amputation, level of blood sugar, combined disease and mortality rate within 5 years from medical record. Statistical analysis was done by Chi-square test and Kaplan-Meier survival test. Results: Mean age of patients who had first experienced amputation was 63.4 years old. The mean duration of diabetes until amputation was $14.5{\pm}7.5$ years. Major amputations were 50 cases and minor amputations 35 cases. 20 patients (23.5%) were suffered ipsilateral secondary surgery including revised stump. Overall 5-year mortality rate was 18.8% (16 cases). Death rate within 1 year was 8.2% (7 cases), mortality rate within 3 years was 14.1% (12 cases). 5-year mortality rate after major amputation was 20% (10 cases) and after minor amputation was 17.1% (6 cases). It was statistically significant (p<0.05). Patient who underwent more than 2 combined vascular related disease had higher mortality rate than diabetic amputee without combined disease (p<0.05). Conclusion: Mortality rate after major amputation was significant higher than amputation after minor amputation in diabetic patients from our data.

Keywords

References

  1. Adler AI, Boyko EJ, Ahroni JH and Smith DG: Lowerextremity amputation in diabetes. The independent effects of peripheral vascular disease, sensory neuropathy, and foot ulcers. Diabetes Care, 22: 1029-1035, 1999. https://doi.org/10.2337/diacare.22.7.1029
  2. Armstrong DG, Lavery LA, Harkless LB and Van Houtum WH: Amputation and reamputation of the diabetic foot. J Am Podiatr Med Assoc, 87: 255-259, 1997.
  3. Bild DE, Selby JV, Sinnock P, Browner WS, Braveman P and Showstack JA: Lower-extremity amputation in people with diabetes. Epidemiology and prevention. Diabetes Care, 12: 24-31, 1989. https://doi.org/10.2337/diacare.12.1.24
  4. Chung CH, Kim DJ, Kim J, et al: Current status of diabetic foot in Korean patients using national health insurance database. J Korean Diabetes Assoc, 30: 372-376, 2006. https://doi.org/10.4093/jkda.2006.30.5.372
  5. Ebskov LB: Diabetic amputation and long-term survival. Int J Rehabil Res, 21: 403-408, 1998. https://doi.org/10.1097/00004356-199812000-00008
  6. Eskelinen E, Eskelinen A, Alback A and Lepantalo M: Major amputation incidence decreases both in non-diabetic and in diabetic patients in Helsinki. Scand J Surg, 95: 185-189, 2006.
  7. Izumi Y, Satterfield K, Lee S, Harkless LB and Lavery LA: Mortality of first-time amputees in diabetics: a 10-year observation. Diabetes Res Clin Pract, 83: 126-131, 2009. https://doi.org/10.1016/j.diabres.2008.09.005
  8. Ku BJ, Choi DE, Jeong JO, et al: The clinical observations in diabetic patients with foot ulcer. J Korean Diabetes Assoc, 3: 244-252, 2002.
  9. Lavery LA, Armstrong DG, Wunderlich RP, Tredwell J and Boulton AJ: Diabetic foot syndrome: evaluating the prevalence and incidence of foot pathology in Mexican Americans and non-Hispanic whites from a diabetes disease management cohort. Diabetes Care, 26: 1435-1438, 2003. https://doi.org/10.2337/diacare.26.5.1435
  10. Lee JS, Lu M, Lee VS, Russell D, Bahr C and Lee ET: Lower-extremity amputation. Incidence, risk factors, and mortality in the Oklahoma Indian Diabetes Study. Diabetes, 42: 876-882, 1993. https://doi.org/10.2337/diabetes.42.6.876
  11. Miyajima S, Shirai A, Yamamoto S, Okada N and Matsushita T: Risk factors for major limb amputations in diabetic foot gangrene patients. Diabetes Res Clin Pract, 71: 272-279, 2006. https://doi.org/10.1016/j.diabres.2005.07.005
  12. Moulik PK, Mtonga R and Gill GV: Amputation and mortality in new-onset diabetic foot ulcers stratified by etiology. Diabetes Care, 26: 491-494, 2003. https://doi.org/10.2337/diacare.26.2.491
  13. Papazafiropoulou A, Tentolouris N, Soldatos RP, et al: Mortality in diabetic and nondiabetic patients after amputations performed from 1996 to 2005 in a tertiary hospital population: a 3-year follow-up study. J Diabetes Complications, 23: 7-11, 2009. https://doi.org/10.1016/j.jdiacomp.2007.11.008
  14. Ramsey SD, Newton K, Blough D, et al: Incidence, outcomes, and cost of foot ulcers in patients with diabetes. Diabetes Care, 22: 382-387, 1999. https://doi.org/10.2337/diacare.22.3.382
  15. Reiber GE: Epidemiology of foot ulcers and amputations in diabetic foot. citedted from Bowker JH and Pfeifer MA: The Diabetic Foot. St. Louis, MO, Mosby, pp 13-32, 2001.
  16. Singh N, Armstrong DG and Lipsky BA: Preventing foot ulcers in patients with diabetes. JAMA, 293: 217-228, 2005. https://doi.org/10.1001/jama.293.2.217
  17. Tentolouris N, Al-Sabbagh S, Walker MG, Boulton AJ and Jude EB: Mortality in diabetic and nondiabetic patients after amputations performed from 1990 to 1995: a 5-year follow-up study. Diabetes Care, 27: 1598-1604, 2004. https://doi.org/10.2337/diacare.27.7.1598
  18. Trautner C, Haastert B, Giani G and Berger M: Amputations and diabetes: a case-control study. Diabet Med, 19: 35-40, 2002. https://doi.org/10.1046/j.1464-5491.2002.00612.x
  19. Tseng CH, Chong CK, Tseng CP, Cheng JC, Wong MK and Tai TY: Mortality, causes of death and associated risk factors in a cohort of diabetic patients after lower-extremity amputation: a 6.5-year follow-up study in Taiwan. Atherosclerosis, 197: 111-117, 2008. https://doi.org/10.1016/j.atherosclerosis.2007.02.011