IMMUNE NETWORK

  • 제9권4호
  • /
  • Pages.133-137
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  • 2009
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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Further Characterization of Activin A-induced IgA Response in Murine B Lymphocytes

  • Lee, Hwa-Joung (Department of Molecular Bioscience, School of Bioscience and Biotechnology, Kangwon National University) ;
  • Kim, Pyeung-Hyeun (Department of Molecular Bioscience, School of Bioscience and Biotechnology, Kangwon National University)
  • 투고 : 2009.07.29
  • 심사 : 2009.08.18
  • 발행 : 2009.08.31
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초록

We have recently shown that activin A, a member of TGF-$\beta$ superfamily, stimulates mouse B cells to express IgA isotype but other isotypes. In the present study, we further characterized effects of activin A on B cell growth and IgA expression. We found that activin A did not have effect on LPS-stimulated cell viability. In parallel, CFSE staining analysis revealed that activin A did not alter cell division. An increase of IgA secretion by activin A was completely abrogated by anti-activin A Ab but not by anti-TGF$\beta$1 Ab. In the same conditions, no other isotypes are significantly affected by each antibody treatment. Finally, activin A, as similar to TGF-$\beta$1, increased IgA secretion by mesenteric lymph node cells. These results suggest that activin A can specifically stimulate IgA response, independent of TGF-$\beta$ in the gut.

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참고문헌

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피인용 문헌

  1. When versatility matters: activins/inhibins as key regulators of immunity vol.90, pp.2, 2009, https://doi.org/10.1038/icb.2011.32
  2. Activin, neutrophils, and inflammation: just coincidence? vol.35, pp.4, 2009, https://doi.org/10.1007/s00281-013-0365-9
  3. Immunoregulation by members of the TGFβ superfamily vol.16, pp.12, 2016, https://doi.org/10.1038/nri.2016.112
  4. TGFβ Superfamily Members as Regulators of B Cell Development and Function—Implications for Autoimmunity vol.19, pp.12, 2018, https://doi.org/10.3390/ijms19123928
  5. Activin-A in the regulation of immunity in health and disease vol.104, pp.None, 2019, https://doi.org/10.1016/j.jaut.2019.102314