생약학회지 (Korean Journal of Pharmacognosy)

  • 제40권2호
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  • Pages.89-98
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  • 2009
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

흰쥐에서 아리스톨로킨산이 생식기능에 미치는 영향

The Effects of Aristolochic Acid on Reproductive Function in Female Rats

  • 박철훈 ((주)케이티앤지 중앙연구원) ;
  • 곽승준 (국립독성과학원 독성연구부)
  • 발행 : 2009.06.30
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초록

The toxicity of aristolochic acid (ArA) has attracted considerable attention since the case of nephropathy regarding diet pill preparations was reported. The present study was performed to determine the reproductive toxicity of ArA in female SD rats. ArA was administered orally to female rats at 2, 8 or 16 mg/kg b.w./day and the females were mated with untreated males and their reproductive status was determined. ArA is well known as PLA2 inhibitor, toxic effects of such a relationship are not yet clear, and in vivo study on this matter are scarce. For this study, ArA was administered to pregnant rats at 10 or 20 mg/kg b.w./day, because premating treatments were not conducted. Administration of 20 mg/kg b.w./day caused infertility or abortion. In ArA-treated groups, PGF2a productions were inhibited and apoptosis were suppressed. Collectively, this study may help to further define the roles of sPLA2 in reproductive organs and to determine the toxic mechanisms of ArA.

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